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公开(公告)号：EP2350052A2
公开(公告)日：2011-08-03
申请号：EP09783505.2
申请日：2009-09-28
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to new compounds of general formula (I), wherein the groups R
1 to R
3 , X
1 , X
2 , X
3 and L
1 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof in such a treatment.-
公开(公告)号：EP2007773A1
公开(公告)日：2008-12-31
申请号：EP07727564.2
申请日：2007-03-30
发明人： STEURER, Steffen , BETZEMEIER, Bodo , MCCONNELL, Darryl , GERSTBERGER, Thomas , GRAUERT, Matthias , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , VAN DER VEEN, Lars , WEYER-CZERNILOFSKY, Ulrike
IPC分类号： C07D513/04 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04
摘要： The invention relates to compounds of general formula (1), wherein R1 to R5 are defined as indicated in claim 1. Said compounds are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation. Also disclosed is the use of the inventive compounds for producing a medicament that has said properties.
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23.发明授权PYRIMIDINDERIVATE, ARZNEIMITTEL ENTHALTEND DIESE VERBINDUNGEN, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权嘧啶衍生物，药物含有该化合物，它们的用途和方法及其生产
公开(公告)号：EP1438053B1
公开(公告)日：2008-09-10
申请号：EP02774710.4
申请日：2002-10-14
申请人： Boehringer Ingelheim Pharma GmbH & Co.KG , Boehringer Ingelheim Pharmaceuticals, Inc. , Boehringer Ingelheim International GmbH
发明人： DAHMANN, Georg , HIMMELSBACH, Frank , WITTNEBEN, Helmut , PAUTSCH, Alexander , PROKOPOWICZ, Anthony, S. , KRIST, Bernd , SCHNAPP, Gisela , STEEGMAIER, Martin , LENTER, Martin , SCHOOP, Andreas , STEURER, Steffen , SPEVAK, Walter
IPC分类号： A61K31/506 , C07D239/48 , C07D403/12 , C07D471/04 , C07D401/12 , C07D413/12 , A61K31/505
CPC分类号： C07D239/48 , C07D231/12 , C07D233/56 , C07D239/50 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10
摘要： The invention concerns tri-substituted pyrimidines of formula (I), wherein Ra to Re are such as defined in the description, said compounds being used for treating diseases characterized by excessive or abnormal cell proliferation. The invention also concerns the use of said compounds for making a pharmaceutical agent exhibiting said properties, as well as methods for making said compounds.
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24.发明公开PYRROLOBENZIMIDAZOLONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS 有权PYRROLOBENZIMIDAZOLONE及其作为抗增殖剂使用
公开(公告)号：EP1756112A1
公开(公告)日：2007-02-28
申请号：EP05742984.7
申请日：2005-05-13
发明人： MCCONNELL, Darryl , STEURER, Steffen , KRIST, Bernd , WEYER-CZERNILOFSKY, Ulrike , IMPAGNATIELLO, Maria , TREU, Matthias , KAUFFMANN-HEFNER, Iris , GARIN-CHESA, Pilar , SCHNAPP, Andreas
IPC分类号： C07D487/04 , A61K31/4184 , C07D235/00 , C07D209/00
CPC分类号： C07D487/04
摘要： The invention relates to pyrrolobenzimidazolone compounds of formula (I), wherein A, T and R1 to R3 are defined as in claim 1, which possess tubulin inhibitory activity and are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
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公开(公告)号：EP3867263A1
公开(公告)日：2021-08-25
申请号：EP19789642.6
申请日：2019-10-14
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公开(公告)号：EP2173734B1
公开(公告)日：2016-03-23
申请号：EP08774579.0
申请日：2008-07-01
发明人： SAPOUNTZIS, Ioannis , ETTMAYER, Peter , KLEIN, Christian , MANTOULIDIS, Andreas , STEURER, Steffen , WAIZENEGGER, Irene
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D417/14 , C07D487/08
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
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公开(公告)号：EP2350052B1
公开(公告)日：2014-08-13
申请号：EP09783505.2
申请日：2009-09-28
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
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28.发明授权PYRIMIDO[5,4-D]PYRIMIDINE DERIVATIVES FOR THE INHIBITION OF TYROSINE KINASES 有权嘧啶并[5,4-D]在酪氨酸激酶的抑制嘧啶类
公开(公告)号：EP2398797B1
公开(公告)日：2013-11-06
申请号：EP10703903.4
申请日：2010-02-17
IPC分类号： C07D471/04 , A61K31/40 , A61P35/00
CPC分类号： C07D471/04
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公开(公告)号：EP2552905A1
公开(公告)日：2013-02-06
申请号：EP11709962.2
申请日：2011-03-25
IPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P35/00
CPC分类号： C07D487/10 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) where in the groups R
0 to R
3 and L are defined as in claim 1, which are suitable for the 5 treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.-
30.发明授权THIAZOLYLDIHYDROINDAZOL-DERIVATE ALS PROTEINKINASE- INHIBITOREN 有权THIAZOLYLDIHYDROINDAZOL衍生物作为蛋白激酶抑制剂
公开(公告)号：EP2007774B1
公开(公告)日：2012-07-25
申请号：EP07727565.9
申请日：2007-03-30
发明人： MCCONNELL, Darryl , BETZEMEIER, Bodo , GERSTBERGER, Thomas , IMPAGNATIELLO, Maria , STEURER, Steffen , VAN DER VEEN, Lars , WEYER-CZERNILOFSKY, Ulrike
IPC分类号： C07D513/04 , A61K31/41 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention comprises compounds of the general formula (1) in which R1 to R6 are each as defined in claim 1 which are suitable for treatment of disorders which are characterized by excessive or abnormal cell proliferation, and their use for producing a medicament with the aforementioned properties.
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