公开(公告)号：EP0990031A2

公开(公告)日：2000-04-05

申请号：EP98904528.1

申请日：1998-01-13

申请人： Human Genome Sciences, Inc.

发明人： WEI, Ying-Fei ,  NI, Jian ,  EBNER, Reinhard ,  YU, Guo-Liang ,  RUBEN, Steven, M. ,  GENTZ, Reiner, L. ,  FENG, Ping

IPC分类号： C12N15/12 ,  C12N15/70 ,  C12N15/85 ,  C12N15/86 ,  C12N1/21 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  A61K38/17

CPC分类号： C07K14/70578 ,  A61K48/00

摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as 'TNFR-5' or 'TR5', and now referred to hereinafter as 'TRAIL receptor without intracellular domain' or 'TRID'. TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

公开(公告)号：EP0972025A1

公开(公告)日：2000-01-19

申请号：EP98903563.9

申请日：1998-01-21

申请人： HUMAN GENOME SCIENCES, INC. ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： NI, Jian ,  ROSEN, Craig, A. ,  DIXIT, Vishva, M. ,  GENTZ, Reiner, L. ,  KENNY, Joseph, J.

IPC分类号： C12N15/12 ,  C12N9/64 ,  A61K38/48 ,  G01N33/50

CPC分类号： C12N9/6475 ,  A61K38/00

摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.

公开(公告)号：EP0958374A1

公开(公告)日：1999-11-24

申请号：EP96933741.0

申请日：1996-08-23

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  GENTZ, Reiner, L. ,  ROSEN, Craig, A.

IPC分类号： C12N15 ,  A61K38 ,  A61K39 ,  A61K49 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12P21

CPC分类号： C07K14/54 ,  A61K38/00

摘要： The present invention concerns a novel T1R-like ligand I protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand I protein. T1R-like ligand I polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.

公开(公告)号：EP0897390A1

公开(公告)日：1999-02-24

申请号：EP96910483.0

申请日：1996-03-14

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  YU, Guo-Liang ,  GENTZ, Reiner, L. ,  DILLON, Patrick J.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K45 ,  A61P3 ,  A61P9 ,  A61P19 ,  A61P29 ,  A61P37 ,  C07H21 ,  C07K1 ,  C07K14 ,  C12N5 ,  C12P21 ,  A61K48

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/411 ,  Y02A50/58

摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

公开(公告)号：EP0896614A1

公开(公告)日：1999-02-17

申请号：EP96910504.0

申请日：1996-03-21

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  YU, Guo-Liang ,  GENTZ, Reiner, L.

IPC分类号： C07K14 ,  A61K38 ,  A61K48

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00

摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

公开(公告)号：EP0856006A1

公开(公告)日：1998-08-05

申请号：EP95935236.0

申请日：1995-09-29

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  YU, Guo-Liang ,  GENTZ, Reiner

IPC分类号： C12N15 ,  C07K14 ,  C12N5 ,  C12P21 ,  A61K48

CPC分类号： C07K14/475 ,  A61K48/00 ,  C12N2799/026

摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及细胞抑制素II生长调节肽，编码所述多肽的多核苷酸，产生所述多肽的方法，特别是通过表达所述多核苷酸，以及所述多肽的激动剂和拮抗剂。 本发明进一步涉及将这些多核苷酸，多肽，激动剂和拮抗剂用于部分涉及研究，诊断和临床领域的应用的方法。

公开(公告)号：EP0842187A1

公开(公告)日：1998-05-20

申请号：EP95922973.0

申请日：1995-06-05

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  YU, Guo-Liang ,  GENTZ, Reiner ,  ROSEN, Craig, A.

IPC分类号： C07K14 ,  A61K38 ,  A61K48

CPC分类号： C07K14/8139 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

摘要翻译： 公开了编码这种多肽的人CysE多肽和DNA（RNA）。 还提供了通过重组技术生产这种多肽的程序。 还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，脓毒性休克，炎症，视网膜刺激，龋齿，c螨和肌肉萎缩的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度改变的诊断方法。

公开(公告)号：EP0814661A1

公开(公告)日：1998-01-07

申请号：EP95910898.0

申请日：1995-01-31

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  GENTZ, Reiner ,  ADAMS, Mark, D.

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P21 ,  A61P25 ,  A61P31 ,  A61P43 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N9 ,  C12P21 ,  C12Q1 ,  C12R1

CPC分类号： C12N9/93 ,  A61K38/00 ,  C07K16/40

摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such plypeptide for the treatment of the proliferation of malignant cells. Antogonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

公开(公告)号：EP0792278A1

公开(公告)日：1997-09-03

申请号：EP95903521.0

申请日：1994-11-07

申请人： HUMAN GENOME SCIENCES, INC.

发明人： YU, Guo-Liang ,  NI, Jian ,  ROSEN, Craig, A.

IPC分类号： G01N33 ,  A61K31 ,  A61K38 ,  A61K45 ,  A61K48 ,  A61P9 ,  A61P29 ,  A61P31 ,  A61P33 ,  A61P35 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  C12R1

CPC分类号： C07K14/525 ,  A61K38/00 ,  Y02A50/412

摘要： A human TNF-gamma polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma nucleic acid sequence or an overexpression of the TNF-gamma polypeptide. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

公开(公告)号：EP1012274B2

公开(公告)日：2011-06-15

申请号：EP98904690.9

申请日：1998-01-27

申请人： HUMAN GENOME SCIENCES, INC. ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： GENTZ, Reiner, L. ,  NI, Jian ,  ROSEN, Craig, A. ,  DIXIT, Vishva, M. ,  PAN, James, G.

IPC分类号： C12N15/12 ,  C07K16/28 ,  C07K14/705

CPC分类号： C07K14/70578

摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.