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21.发明公开ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS 审中-公开哮喘相关因素的定位元素治疗特异反应性过敏，包括哮喘和相关疾病
公开(公告)号：EP1025223A2
公开(公告)日：2000-08-09
申请号：EP98948311.0
申请日：1998-09-18
IPC分类号： C12N15/12 , C12N15/11 , C12N15/70 , C12N1/21 , C07K14/705 , C07K16/28 , A61K31/70 , A61K39/395 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00
摘要： A new gene in the G-coupled protein receptor family is discribed that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and certain lymphomas or leukemias. A method for recombinantly producing the polypeptide encoded by the gene is disclosed. A method for identification and use of agonist and antagonists of GCR9 to treat atopic allergy, asthma-related disorders and certain lymphomas or leukemias is also included. A method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders and certain lymphomas or leukemias by measuring the level of GCR9 in biological samples using antibody specific for the GCR9 polypeptide or nucleic acid probes specific for GCR9 nucleic acids is also disclosed.
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22.发明公开ISOLATED PEPTIDES WHICH FORM COMPLEXES WITH MHC MOLECULE HLA-C-CLONE 10 AND USES THEREOF 失效与MHCMULEKÜLHLA-C克隆10复杂的形式和用途分离的肽
公开(公告)号：EP0711173A1
公开(公告)日：1996-05-15
申请号：EP94920715.0
申请日：1994-06-10
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumorrejection antigen precursor molecules are described.
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