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1.发明授权
公开(公告)号：EP0789591B1
公开(公告)日：2003-04-16
申请号：EP95913476.8
申请日：1995-01-26
发明人： VAN DER BRUGGEN, Pierre , SZIKORA, Jean-Pierre , COULIE, Pierre , WILDMANN, Claude , BOEL, Pascale , BOON-FALLEUR, Thierry
IPC分类号： C12N15/12 , A61K48/00 , C12Q1/68 , C07K7/06 , C07K14/705
CPC分类号： G01N33/5011 , A61K35/17 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/70539 , G01N2333/70539 , G01N2800/52
摘要： This invention relates to MAGE-1 derived nonapeptides. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
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2.发明公开MAGE-10 ENCODING cDNA, THE TUMOR REJECTION ANTIGEN PRECURSOR MAGE-10, ANTIBODIES SPECIFIC TO THE MOLECULE, AND USES THEREOF 失效MAGE-10的cDNA编码的，肿瘤ABSTOSSUNGSGEN-PRE-MAGE-10，对于该分子特异性ANTIKOERPER及其应用
公开(公告)号：EP0948517A1
公开(公告)日：1999-10-13
申请号：EP97940980.0
申请日：1997-09-10
发明人： RIMOLDI, Donata , JONGENEEL, Victor , COULIE, Pierre , CERROTTINI, Jean-Charles , CARREL, Stefan , REED, Daryl
IPC分类号： G01N33 , A61K39 , A61P35 , A61P37 , C07K1 , C07K14 , C07K16 , C07K17 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1
CPC分类号： C07K14/4748 , A61K39/00 , C12Q1/6886 , C12Q2600/158
摘要： Isolated cDNA molecules which encode the tumor rejection antigen precursor MAGE-10, the protein itself, antibodies to it, and uses of these are a part of the invention.
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3.发明公开ISOLATED NUCLEIC ACID MOLECULE CODING FOR TUMOR REJECTION ANTIGEN PRECURSOR DAGE AND USES THEREOF 失效分离的核酸分子FOR THE TUMORABSTOSSUNGS抗原前体DAGE CODES和需求
公开(公告)号：EP0783511A1
公开(公告)日：1997-07-16
申请号：EP95934504.0
申请日：1995-09-21
IPC分类号： C12N15 , A61K35 , A61K38 , A61K39 , A61K48 , A61P35 , A61P37 , C07K7 , C07K14 , C12N5 , C12Q1
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
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公开(公告)号：EP0553260A1
公开(公告)日：1993-08-04
申请号：EP91919956.0
申请日：1991-09-12
CPC分类号： C07K14/7155 , A61K38/00
摘要： L'invention concerne des molécules de récepteur d'interleukine pratiquement pure, ainsi que leurs utilisations. La molécule est une glycoprotéine d'environ 64 kilodaltons qui, lors de sa digestion avec N-glycosidase F, produit un peptide d'environ 54 kilodaltons. La figure n° 2 représente la liaison d'IL-9 radioactive avec des cellules TS1, qui contiennent le récepteur d'IL-9, sur une période de temps avec différentes températures d'incubation. On peut utiliser la molécule pratiquement purifiée pour inhiber l'effet d'IL-9 présente dans un échantillon, pour déterminer la présence de cellules qui contiennent le récepteur d'IL-9, et pour rechercher les produits pharmaceutiques efficaces pour traiter les états qui se caractérisent par une prolifération cellulaire excessive due à l'IL-9.
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公开(公告)号：EP1165776A1
公开(公告)日：2002-01-02
申请号：EP00910250.0
申请日：2000-02-18
IPC分类号： C12N15/12 , C07K14/47 , G01N33/566 , A61K38/17 , C07K16/28 , A61K39/395 , C12N15/62
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the EphA3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the EphA3 gene.
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6.发明公开TUMOR REJECTION ANTIGENS PRESENTED BY HLA-B44 MOLECULES, AND USES THEREOF 失效由HLA-B44分子提呈肿瘤ABSTOSSUNGSANTIGENE和用途
公开(公告)号：EP0876397A1
公开(公告)日：1998-11-11
申请号：EP97906894.0
申请日：1997-02-05
发明人： HERMAN, Jean , COULIE, Pierre , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUESCHER, Immanuel
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/136 , G01N33/56977 , G01N33/57492
摘要： Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are derived from MAGE tumor rejection antigen precursors.
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7.发明公开ISOLATED NUCLEIC ACID MOLECULE WHICH CODES FOR A TUMOR REJECTION ANTIGEN PRECURSOR, AND USES THEREOF 失效一种分离的核酸，THE为预TUMORABSTOSSUNGSANTIGEN CODES，它的使用
公开(公告)号：EP0771358A1
公开(公告)日：1997-05-07
申请号：EP95922914.0
申请日：1995-05-31
IPC分类号： G01N33 , A61K35 , A61K39 , A61P35 , C07H21 , C07K7 , C07K14 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： C12Q1/6881 , A61K39/00 , C07K14/4748 , C07K14/70539 , C12Q1/6886 , C12Q2600/172 , G01N33/56977
摘要： A nucleic acid molecule which codes for a tumor antigen precursor which is in turn processed to antigens presented by an HLA molecule is described. The HLA molecule may be HLA-A2, HLA-A28, HLA-B13, HLA-B44 or HLA-Cw6. The antigens are also described. These materials are useful in diagnostic and therapeutic methodologies. The tumor rejection antigen precursor is not tyrosinase, which has been previously identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44. The figure sets forth data regarding cytolytic activity of lymphocytes obtained in autologous mixed lymphocyte-tumor cell cultures.
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8.发明公开ISOLATED PEPTIDES WHICH FORM COMPLEXES WITH MHC MOLECULE HLA-C-CLONE 10 AND USES THEREOF 失效与MHCMULEKÜLHLA-C克隆10复杂的形式和用途分离的肽
公开(公告)号：EP0711173A1
公开(公告)日：1996-05-15
申请号：EP94920715.0
申请日：1994-06-10
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/70539
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as BAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumorrejection antigen precursor molecules are described.
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9.发明公开
公开(公告)号：EP3786187A1
公开(公告)日：2021-03-03
申请号：EP20201515.2
申请日：2014-08-01
发明人： LUCAS, Sophie , COULIE, Pierre , CUENDE VILLASUR, Julia , DUMOUTIER, Laure , RENAULD, Jean-Christophe , VAN DER WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Hans , DE BOECK, Gitte
摘要： The present invention relates to a protein binding to GARP in the presence of TGF-β and uses thereof.
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公开(公告)号：EP1575994B1
公开(公告)日：2013-01-09
申请号：EP03776190.5
申请日：2003-09-26
发明人： MA, Wenbin , GERMEAU, Catherine , VAN DEN EYNDE, Benoit , COULIE, Pierre , FALLEUR, Thierry, Boon , VIGNERON, Nathalie
CPC分类号： C07K14/4748 , A61K38/00
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