公开(公告)号：EP0851753B1

公开(公告)日：2003-11-19

申请号：EP96931227.1

申请日：1996-09-18

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： MURATA, Saburo ,  SHIMOJO, Fumio ,  TOKUNAGA, Yuji ,  HATA, Takehisa

IPC分类号： A61K9/00

CPC分类号： A61K9/008 ,  A61K9/12 ,  A61K31/4433

公开(公告)号：EP1106606A3

公开(公告)日：2003-10-22

申请号：EP01102827.1

申请日：1994-09-21

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： Ohkubo, Mitsuru ,  Takahashi, Fumie ,  Yamanaka, Toshio ,  Sakai, Hiroyoshi ,  Kato, Masayuki

IPC分类号： C07D211/60 ,  C07K5/06 ,  C07D401/12 ,  C07D405/12 ,  A61K31/445 ,  C07D401/06 ,  C07D211/56

CPC分类号： C07D401/06 ,  C07D211/56 ,  C07D211/60 ,  C07D405/14 ,  C07D413/06 ,  Y02P20/55

摘要： This invention relates to β-alanine derivatives represented by the following formula : wherein each symbol is as defined in the specification and pharmaceutically acceptable salt thereof which is glycoprotein IIb/IIIa antagonist, inhibitor of blood platelets aggregation and inhibitor of the binding of fibrinogen to blood platelets, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the prevention and/or treatment diseases indicated in the specification to a human being or an animal.

公开(公告)号：EP1051415B1

公开(公告)日：2003-09-24

申请号：EP99900176.1

申请日：1999-01-11

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： SETOI, Hiroyuki ,  OHKAWA, Takehiko ,  SAWADA, Yuki ,  OSODA, Kazuhiko ,  OKU, Teruo

IPC分类号： C07D403/12 ,  A61K31/55 ,  C07D401/14 ,  C07D498/04 ,  C07D413/12 ,  C07D417/12 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： A compound of formula (I) wherein A is an optionally substituted heterocyclic group; R is a lower alkoxy; Z is C=O or CH2; and B is a saturated or unsaturated condensed ring group selected from the group consisting of benzazepinyl, benzodiazepinyl, pyridoazepinyl, pyridodiazepinyl, thienoazepinyl, benzoxazepinyl, benzothiazepinyl, imidazobenzazepinyl, pyridobenzoxazepinyl and indolinyl, each member being optionally substituted, and a salt thereof, which possess vasopressin antagonistic activity and are useful as vasopressin antagonists.

公开(公告)号：EP1315494A1

公开(公告)日：2003-06-04

申请号：EP01963255.3

申请日：2001-09-05

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： KELLY, John, Shearer ,  HODGKISS, Joseph, Peter ,  SHARKEY, John

IPC分类号： A61K31/445 ,  A61K31/00 ,  A61K31/495 ,  C07D211/58 ,  C07D211/96 ,  C07D295/18 ,  C07D295/20 ,  C07D295/22 ,  C07D401/12 ,  C07D213/81

CPC分类号： A61K31/4965

摘要： The present invention relates to an agent for modulating excitatory synaptic transmission which contains a compound having α7 nicotinic acetylcholine receptor activation property as an active ingredient, and the production of such an agent. It further relates to a pharmaceutical composition which contains such a compound together with a pharmaceutically acceptable carrier or excipient, and a method for modulating excitatory synaptic transmission which comprises administering such a composition. There is also provided a method for screening an agent for modulating excitatory synaptic transmission which comprises using α7 nicotinic acetylcholine receptor activation property as an index. The present invention is useful for the prophylaxis and/or treatment of cerebral diseases, including dementia, amnesia, manic-depressive psychosis, schizophrenia, Parkinson's disease and psychosomatic disease.

公开(公告)号：EP1042277B1

公开(公告)日：2003-04-23

申请号：EP98959166.4

申请日：1998-12-11

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： HATTORI, Kouji ,  ITANI, Hiromichi ,  TANAKA, Akira ,  SHIRAGA, Toshifumi

IPC分类号： C07C271/28 ,  A61K31/27

CPC分类号： C07C271/28 ,  C07C2602/10

公开(公告)号：EP1294700A2

公开(公告)日：2003-03-26

申请号：EP01943821.7

申请日：2001-06-25

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： TAKE, Kazuhiko,Fujisawa Pharm. Co., Ltd ,  KASAHARA, Chiyoshi,Fujisawa Pharm. Co., Ltd ,  SHIGENAGA, Shinji,Fujisawa Pharm. Co., Ltd ,  AZAMI, Hidenori,Fujisawa Pharm. Co., Ltd ,  EIKYU, Yoshiteru,Fujisawa Pharm. Co., Ltd ,  NAKAI, Kazuo,Fujisawa Pharm. Co., Ltd ,  MORITA, Masataka,Fujisawa Pharm. Co., Ltd

IPC分类号： C07D241/04 ,  C07D241/08 ,  C07D487/04 ,  A61K31/4965 ,  A61P11/06

CPC分类号： C07D265/30 ,  C07C45/71 ,  C07D241/04 ,  C07D241/08 ,  C07D403/10 ,  C07D487/04 ,  C07C47/575

摘要： A compound of the formula (I): in which Z, R?1, R2, R8, R10, R11, R12, R13 and R14¿ are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

公开(公告)号：EP1260146A4

公开(公告)日：2003-03-19

申请号：EP01904354

申请日：2001-02-08

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： NAKAMURA TOMOYASU

IPC分类号： A23L27/00 ,  A23L27/20 ,  A23L1/22 ,  A23L1/226

CPC分类号： A23L27/82

摘要： The flavor of a seasoning or a food is enhanced by adding a flavor-enhancing agent which contains as the active ingredient a nontoxic salt of gluconic acid.

摘要翻译： 调味料或食品的风味通过加入含有葡萄糖酸无毒盐作为活性成分的风味增强剂来增强。

公开(公告)号：EP1230922A4

公开(公告)日：2003-01-29

申请号：EP00969858

申请日：2000-10-18

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： KOYAMA HIRONARI ,  OKADA MASAAKI

IPC分类号： A23K1/16 ,  A23K1/18 ,  A61K31/191 ,  A61K31/366 ,  A61P43/00 ,  A61K31/19 ,  A61K31/365 ,  C07C59/105

CPC分类号： A61K31/366 ,  A23K10/18 ,  A23K20/105 ,  A23K20/126 ,  A23K20/158 ,  A23K20/163 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A61K31/19 ,  A61K31/191 ,  Y10S426/807

摘要： Agents for promoting fattening of animals which contain as the active ingredient(s) at least one member selected from among acids originating in hexoses, non-toxic salts thereof and intramolecular esterification products thereof; and a method of promoting fattening by using these agents.

摘要翻译： 用于促进含有至少一种选自下列成员作为活性成分的动物的育肥剂：源自己糖的酸，其无毒盐和其分子内酯化产物; 以及通过使用这些药剂促进育肥的方法。

公开(公告)号：EP0788511B1

公开(公告)日：2002-12-11

申请号：EP95932935.0

申请日：1995-09-29

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： OHKI, Hidenori ,  TOMISHIMA, Masaki ,  YAMADA, Akira ,  TAKASUGI, Hisashi

IPC分类号： C07K7/56 ,  A61K38/12

CPC分类号： C07K7/56 ,  A61K38/00

公开(公告)号：EP1259499A1

公开(公告)日：2002-11-27

申请号：EP01906142.3

申请日：2001-02-20

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： NEYA, Masahiro,c/o Fujisawa Pharm. Co., Ltd. ,  YAMAZAKI, Hitoshi,c/o Fujisawa Pharm. Co.,Ltd. ,  OHNE, Kazuhiko,c/o Fujisawa Pharm. Co., Ltd. ,  SAWADA, Yuki,c/o Fujisawa Pharm. Co., Ltd. ,  MIZUTANI, Tsuyoshi,c/o Fujisawa Pharm. Co., Ltd. ,  IMAMURA, Yoshimasa,c/o Fujisawa Pharm. Co., Ltd. ,  MUKAI, Noriko

IPC分类号： C07D281/06 ,  A61K31/55 ,  A61P29/02 ,  C07D417/04 ,  C07D417/14 ,  C07D417/12 ,  C07D417/06

CPC分类号： C07D417/04 ,  C07D281/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

摘要： A compound of formula (I) in which R1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R2 is amidated carboxy, R3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor α (TNF α).