摘要:
The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.
摘要:
The invention relates to the use of porphyrin synthesis substances, in particular 5-amonolevulinic acid, if necessary in combination with salicylates in the form of acetylsalicyc acid and with antioxydising agents in the form of ascorbic acid when a phototherapy is carried out with a light emission whose wavelength ranges from 400 to 700 nm pour treating inflammatory processes, for instance on the skin and/or articulations of mammalians and human beings, in particular for curing arthritis, simple psoriasis, arthopathic psoriasis and neuropathies such as a carpal tunnel syndrome or Bechterev's disease.
摘要:
The method relates to the use of a photosensitizer selected from 5-aminolevulinic acid (5-ALA) and 5-ALA derivatives, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament for use in treating a wound. Examples of wounds which may be treated in accordance with the invention include those resulting from non-physiological processes, e.g. from surgery or from physical injury, abrasions, lacerations, and wounds arising from a thermal injury (e.g. a burn or a wound arising from any cryo-based treatment). Ulcers, e.g. leg ulcers, venous ulcers and gastric ulcers, may also be successfully treated in accordance with the methods of the invention.
摘要:
The present invention relates to a composition comprising a nano-emulsion that contains 5-aminolevulinic acid as well as a carrier in an aqueous phase. This invention also relates to a pharmaceutical preparation containing this composition. The nano-emulsions of this type can be used in photodynamic therapy as well as in the photodiagnostic detection of proliferative cells.
摘要:
The present invention relates to a pharmaceutical composition for use as a medicament, preferably for the treatment or diagnosis of disorders or abnormalities of epithelial-lined surfaces, preferably mucosa-lined surfaces, comprising a photochemotherapeutic agent together with a mucoadhesive agent, optionally together with at lest one surface penetration assisting agent and optionally with one or more chelating agents, and products and kits for performing the invention.
摘要:
Die Erfindung betrifft eine Tumorzellenidentifizierungsvorrichtung zur automatisierten in vitro Identifizierung von Tumorzellen, in denen Protoporphyrin IX angereichert ist, in einer Flüssigkeit, wobei die Tumorzellenidentifizierungsvorrichtung (10) eine Lichtquelle (18) und ein Sensorelement (24) aufweist, wobei in der Flüssigkeit befindliche Zellen durch die Lichtquelle (18) mit Licht einer Wellenlänge von im Wesentlichen 400 nm gesamtheitlich oder sequentiell, von Fremdlicht abgeschlossen bestrahlbar sind, wobei durch das Sensorelement (24) eine von den Zellen in der Flüssigkeit aufgrund der Bestrahlung emittierte Lichtmenge von Licht einer Wellenlänge von im Wesentlichen 630 bis 700 nm pro Zeiteinheit gesamtheitlich oder sequentiell erfaßbar ist und mindestens ein für die erfaßte Lichtmenge charakteristisches Signal erzeugbar ist, wobei die Flüssigkeit innerhalb der Tumoridentifizierungsvorrichtung (10) von Fremdlicht abgeschlossen für die Bestrahlung bereitstellbar ist. Die Erfindung betrifft auch ein entsprechendes Tumorzellenidentifizierungsverfahren.
摘要:
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluroescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.
摘要:
Medicaments for detecting and treating malignant and non-malignant tissue abnormalities and lesions of the skin; conjunctiva; respiratory, digestive and vaginal mucosa; endometrium and urothelium; and for ablating the endometrial tissue and treating body fluids containing suspended abnormal cells, and for treating cancers of the nervous system are prepared from 5-aminolevulinic acid or precursor thereof and subsequently administered to the patient in an amount sufficient to induce syntheses fluorescence and/or photosensitizing concentrations or protoporphyrin IX in the abnormal cells, followed by exposure of the abnormal cells to light of photoactivating wavelengths.