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公开(公告)号：EP2235534A1
公开(公告)日：2010-10-06
申请号：EP08865900.8
申请日：2008-12-19
申请人： Proteomika, S.L. , Monasterio, Alberto , Pascual, Javier , Toro, Amaia , Martínez, Antonio , Simón, Laureno , Marimón, Jose Maria , Perez-Trallero, Emilio
发明人： MONASTERIO, Alberto , PASCUAL, Javier , TORO, Amaia , MARTÍNEZ, Antonio , SIMÓN, Laureno , MARIMÓN, Jose, Maria , PEREZ-TRALLERO, Emilio
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56944 , G01N33/6845 , G01N2333/3156
摘要： Methods for identifying strains of bacteria, particularly methods for serotyping Streptococcus pneumoniae in a sample, methods for detecting and/or classifying S. pneumoniae infection by serotype, array devices and kits for use in such methods are disclosed. Array devices comprise a set of capture antibodies immobilised on a substrate at pre-determined array positions, wherein the set of capture antibodies comprises serotype-distinguishing antibodies which differ in their binding specificity for different S. pneumoniae serotypes. Serotyping methods may employ whole cell detection utilising one or more detectable labels, including in situ labelling of array-bound cells.
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公开(公告)号：EP2162546A1
公开(公告)日：2010-03-17
申请号：EP08780704.6
申请日：2008-05-28
发明人： NAHM, Moon, H. , PARK, In, Ho
IPC分类号： C12P19/04
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/55588 , A61K2039/6031 , A61K2039/6081 , C07K16/1275 , C07K2317/24 , C12N1/20 , C12P19/04 , C12Q1/14 , C12Q1/689 , C12R1/46 , G01N33/56944 , G01N2333/3156
摘要： Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit ->2) glucose 1 (1->3) glucose 2 (1->3) rhamnose (1->4) ribitol (5->phosphate. This new serotype may be included in pneumococcal vaccines.
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公开(公告)号：EP3230297B1
公开(公告)日：2018-10-17
申请号：EP15724583.8
申请日：2015-05-15
IPC分类号： C07H15/04 , A61K31/7028 , A61P31/04
CPC分类号： A61K39/092 , A61K31/715 , A61K39/385 , A61K2039/575 , A61K2039/627 , C07H15/02 , C07H15/04 , C07H15/18 , C08B37/006 , G01N33/56944 , G01N2333/3156 , G01N2400/00 , G01N2469/20
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 4 capsular polysaccharide and conjugates thereof. Said conjugate and a pharmaceutical composition containing said conjugate are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae serotype 4. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
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公开(公告)号：EP2162546B1
公开(公告)日：2018-10-03
申请号：EP08780704.6
申请日：2008-05-28
发明人： NAHM, Moon, H. , PARK, In, Ho
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/55588 , A61K2039/6031 , A61K2039/6081 , C07K16/1275 , C07K2317/24 , C12N1/20 , C12P19/04 , C12Q1/14 , C12Q1/689 , C12R1/46 , G01N33/56944 , G01N2333/3156
摘要： Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit ->2) glucose 1 (1->3) glucose 2 (1->3) rhamnose (1->4) ribitol (5->phosphate. This new serotype may be included in pneumococcal vaccines.
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公开(公告)号：EP3197907A1
公开(公告)日：2017-08-02
申请号：EP15770548.4
申请日：2015-09-28
发明人： SEEBERGER, Peter , PEREIRA, Claney Lebev , ANISH, Chakkumkal , SCHUMANN, Benjamin , PARAMESWARAPPA, Sharavathi Guddehalli , HAHM, Heung Sik , GOVINDAN, Subramanian
IPC分类号： C07H15/04 , A61K39/00 , A61K31/7028 , A61K31/715 , C07K16/00 , C07K19/00 , A61P31/04
CPC分类号： A61K39/092 , A61K31/7028 , A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/575 , A61K2039/6037 , A61K2039/627 , C07H15/04 , C07H15/18 , C07K16/1271 , G01N33/56944 , G01N2333/3156
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
摘要翻译： 本发明涉及与肺炎链球菌血清型8荚膜多糖相关的通式（I）的合成糖类，其缀合物以及所述糖类和缀合物在人类和/或动物宿主中用于产生保护性免疫应答的用途。 此外，通式（I）的合成糖结构可用作用于检测针对肺炎链球菌细菌的抗体的免疫学测定中的标记物。
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26.发明公开CHIPS, DETECTION SYSTEMS, AND METHODS FOR MULTIPLEX PNEUMOCOCCUS SEROLOGY 审中-公开CHIPS，NACHWEISSYSTEME UND VERFAHRENFÜRMULTIPLEX-PNEUMOKOKKEN-SEROLOGIE
公开(公告)号：EP3055433A4
公开(公告)日：2017-05-03
申请号：EP14851985
申请日：2014-10-09
申请人： UNIV ROCHESTER , UAB RES FOUND
发明人： MILLER BENJAMIN L , NAHM MOON H
IPC分类号： G01N33/569 , G01N21/21 , G01N21/55 , G01N33/543
CPC分类号： G01N33/56944 , G01N21/211 , G01N21/55 , G01N33/54373 , G01N2201/06113 , G01N2201/0683 , G01N2333/3156
摘要： According to aspects illustrated herein, there are provided a sensor chip suitable for serological detection of Streptococcus pneumoniae, a method for detecting serotypes of Streptococcus pneumoniae using the sensor chip, a detection system that includes the sensor chip, and a method for detecting serotypes of Streptococcus pneumoniae using the detection system described herein.
摘要翻译： 根据本文所示的方面，提供了一种适用于肺炎链球菌血清学检测的传感器芯片，一种使用传感器芯片检测肺炎链球菌血清型的方法，一种包括传感器芯片的检测系统以及一种用于检测链球菌血清型的方法 使用本文所述的检测系统进行肺炎。
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公开(公告)号：EP3126378A1
公开(公告)日：2017-02-08
申请号：EP15779886.9
申请日：2015-04-02
发明人： XIE, Zijian , BANERJEE, Moumita
IPC分类号： C07K14/47 , C07K7/08 , G01N33/573
CPC分类号： C12N9/14 , A61K38/00 , A61K38/46 , A61K45/06 , C07K7/08 , C07K2319/00 , C07K2319/01 , C12Q1/485 , C12Q1/50 , C12Y306/03009 , G01N33/5044 , G01N33/573 , G01N2333/3153 , G01N2333/3156 , G01N2333/91 , G01N2333/9723
摘要： Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.
摘要翻译： 提供非天然存在的肽作为强心型类固醇的Src SH2结构域拮抗剂。 包含肽的药物组合物也与编码肽的载体一起提供。 进一步提供治疗Src相关疾病并降低细胞中Src活性的方法，包括给予或接触细胞与有效量的肽。
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28.发明公开CHIPS, DETECTION SYSTEMS, AND METHODS FOR MULTIPLEX PNEUMOCOCCUS SEROLOGY 审中-公开CHIPS，NACHWEISSYSTEME UND VERFAHRENFÜRMULTIPLEX-PNEUMOKOKKEN-SEROLOGIE
公开(公告)号：EP3055433A1
公开(公告)日：2016-08-17
申请号：EP14851985.3
申请日：2014-10-09
IPC分类号： C12Q1/70
CPC分类号： G01N33/56944 , G01N21/211 , G01N21/55 , G01N33/54373 , G01N2201/06113 , G01N2201/0683 , G01N2333/3156
摘要： According to aspects illustrated herein, there are provided a sensor chip suitable for serological detection of Streptococcus pneumoniae, a method for detecting serotypes of Streptococcus pneumoniae using the sensor chip, a detection system that includes the sensor chip, and a method for detecting serotypes of Streptococcus pneumoniae using the detection system described herein.
摘要翻译： 根据本文所述的方面，提供了适用于肺炎链球菌的血清学检测的传感器芯片，使用传感器芯片检测肺炎链球菌血清型的方法，包括传感器芯片的检测系统和检测链球菌血清型的方法 使用本文所述的检测系统的肺炎链球菌。
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公开(公告)号：EP2833148A4
公开(公告)日：2015-07-22
申请号：EP13769634
申请日：2013-03-29
申请人： OTSUKA PHARMA CO LTD
发明人： FUKUSHIMA KIYOYASU , TANAKA YUMI
IPC分类号： G01N33/569 , C12Q1/04 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/689 , G01N33/5308 , G01N33/56911 , G01N33/56944 , G01N33/56972 , G01N2333/3156
摘要： Provided is a method that can more objectively and rapidly determine severity of pneumococcal pneumonia using blood of a subject. The method determines severity of pneumococcal pneumonia, the method including determining the severity based on the presence or absence of a pneumococcal antigen in blood collected from a subject and at least one biochemical value selected from a blood C-reactive protein (CRP) level, a white blood cell (WBC) count and a blood urea nitrogen (BUN) level.
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30.发明公开METHOD OF DIAGNOSING PNEUMONIA BY DETECTING A VOLATILE ORGANIC COMPOUND 有权DIAGNOSEVERFAHRENFÜRLUNGENENTZNDNDDURCH NACHWEIS EINERFLÜCHTIGENORGANISCHEN VERBINDUNG
公开(公告)号：EP2788496A1
公开(公告)日：2014-10-15
申请号：EP12794719.0
申请日：2012-12-03
发明人： RÜTHER, Horst , AMANN, Anton
IPC分类号： C12Q1/04 , C12Q1/14 , G01N33/497
CPC分类号： C12Q1/14 , C12Q1/04 , G01N33/497 , G01N2033/4977 , G01N2333/21 , G01N2333/285 , G01N2333/31 , G01N2333/315 , G01N2333/3156 , G01N2800/26
摘要： The present invention relates to a method of diagnosing an existing or developing acute pneumonia induced by a microorganism by detecting one or more volatile organic compound(s) in a subject's sample and the use of one or more volatile organic compound(s) for the detection of Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae or Haemophilus influenza and optionally opportunistic pathogen Candida albicans.
摘要翻译： 本发明涉及通过检测受试者样品中的一种或多种挥发性有机化合物和使用一种或多种挥发性有机化合物进行检测来诊断由微生物诱导的现有或发展中的急性肺炎的方法 金黄色葡萄球菌，铜绿假单胞菌，肺炎链球菌或嗜血杆菌流感和任选的机会性病原体白色念珠菌。
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