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1.发明授权PROTEIN AND PEPTIDE-FREE SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3 有权蛋白和无肽合成疫苗对抗链球菌肺炎3型
公开(公告)号：EP3046587B1
公开(公告)日：2018-01-31
申请号：EP14776605.9
申请日：2014-09-18
发明人： RATHWELL, Dominea , PARAMESWARAPPA, Sharavathi Guddehalli , GOVINDAN, Subramanian , ANISH, Chakkumkal , PEREIRA, Claney Lebev , SEEBERGER, Peter H. , BRÖCKER, Felix
CPC分类号： A61K39/092 , A61K47/54 , A61K47/543 , A61K47/545 , A61K47/549 , A61K47/55 , A61K47/61 , A61K2039/55555 , A61K2039/575 , A61K2039/6012 , A61K2039/6087
摘要： The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae , and more specifically against diseases associated with Streptococcus pneumoniae type 3.
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公开(公告)号：EP3197907B1
公开(公告)日：2019-09-04
申请号：EP15770548.4
申请日：2015-09-28
发明人： SEEBERGER, Peter , PEREIRA, Claney Lebev , ANISH, Chakkumkal , SCHUMANN, Benjamin , PARAMESWARAPPA, Sharavathi Guddehalli , HAHM, Heung Sik , GOVINDAN, Subramanian
IPC分类号： C07H15/04 , A61K39/00 , A61K31/7028 , A61K31/715 , C07K16/00 , C07K19/00 , A61P31/04
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公开(公告)号：EP3197907A1
公开(公告)日：2017-08-02
申请号：EP15770548.4
申请日：2015-09-28
发明人： SEEBERGER, Peter , PEREIRA, Claney Lebev , ANISH, Chakkumkal , SCHUMANN, Benjamin , PARAMESWARAPPA, Sharavathi Guddehalli , HAHM, Heung Sik , GOVINDAN, Subramanian
IPC分类号： C07H15/04 , A61K39/00 , A61K31/7028 , A61K31/715 , C07K16/00 , C07K19/00 , A61P31/04
CPC分类号： A61K39/092 , A61K31/7028 , A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/575 , A61K2039/6037 , A61K2039/627 , C07H15/04 , C07H15/18 , C07K16/1271 , G01N33/56944 , G01N2333/3156
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 8 capsular polysaccharide, conjugates thereof and the use of said saccharides and conjugates for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide structures of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
摘要翻译： 本发明涉及与肺炎链球菌血清型8荚膜多糖相关的通式（I）的合成糖类，其缀合物以及所述糖类和缀合物在人类和/或动物宿主中用于产生保护性免疫应答的用途。 此外，通式（I）的合成糖结构可用作用于检测针对肺炎链球菌细菌的抗体的免疫学测定中的标记物。
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4.发明公开PROTEIN AND PEPTIDE-FREE SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 3 有权蛋白多肽合成酶IMPFSTOFFE GEGEN STREPTOCOCCUS PNEUMONIAE TYP 3
公开(公告)号：EP3046587A1
公开(公告)日：2016-07-27
申请号：EP14776605.9
申请日：2014-09-18
发明人： RATHWELL, Dominea , PARAMESWARAPPA, Sharavathi Guddehalli , GOVINDAN, Subramanian , ANISH, Chakkumkal , PEREIRA, Claney Lebev , SEEBERGER, Peter H. , BRÖCKER, Felix
CPC分类号： A61K39/092 , A61K47/54 , A61K47/543 , A61K47/545 , A61K47/549 , A61K47/55 , A61K47/61 , A61K2039/55555 , A61K2039/575 , A61K2039/6012 , A61K2039/6087
摘要： The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae , and more specifically against diseases associated with Streptococcus pneumoniae type 3.
摘要翻译： 本发明提供了含有合成碳水化合物和载体分子的蛋白质和无肽结合物，其中合成碳水化合物是肺炎链球菌3型荚膜多糖相关碳水化合物，载体分子是鞘糖脂。 所述缀合物及其药物组合物可用于针对与肺炎链球菌相关的疾病的免疫，更具体地针对与3型肺炎链球菌相关的疾病。
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