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公开(公告)号：EP4410841A1
公开(公告)日：2024-08-07
申请号：EP22875179.8
申请日：2022-09-30
发明人： MAO, Langyong , YING, Hua , XUE, Yi , JIN, Xinsheng , TAO, Weikang
摘要： An anti-IL23 antibody fusion protein and uses thereof, the anti-IL23 antibody fusion protein containing anti IL23 antibodies and TAC polypeptides, and the IL23 antibodies specifically binding the human IL23 p19 subunit. The anti-IL23 antibody fusion protein can be used for the treatment or improvement of B cell disorders or autoimmune diseases.
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公开(公告)号：EP4408479A1
公开(公告)日：2024-08-07
申请号：EP22877604.3
申请日：2022-09-30
发明人： KLEY, Nikolai , DEPLA, Erik , ZABEAU, Lennart
CPC分类号： C07K2319/3020130101 , C07K14/57 , C07K14/525 , C07K2319/0120130101 , A61K47/65 , A61K47/68 , A61K47/6849 , A61K47/6867 , A61K38/00
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公开(公告)号：EP4401832A1
公开(公告)日：2024-07-24
申请号：EP22870960.6
申请日：2022-09-15
发明人： CHAN, Kui K. , PROCKO, Erik , SHIRLEY, Kristie
IPC分类号： A61P11/00 , A61K39/395 , A61K47/68 , A61K39/00 , A61K48/00 , C07K14/00 , C07K16/10 , C12N15/62 , C12N15/85
CPC分类号： A61K39/395 , A61P11/00 , C07K2317/62220130101 , C07K2317/56520130101 , C12N9/485 , C12Y304/17023 , A61K39/0005 , A61P31/14 , A61K2039/605620130101 , C07K2319/3020130101 , C07K16/1003 , A61K39/00
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公开(公告)号：EP4401757A1
公开(公告)日：2024-07-24
申请号：EP22800037.8
申请日：2022-09-13
CPC分类号： C12N9/22 , C12N15/907 , C07K2319/8020130101 , A61K38/00 , C07K2319/8120130101
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25.发明公开
公开(公告)号：EP4400586A1
公开(公告)日：2024-07-17
申请号：EP22867342.2
申请日：2022-09-06
发明人： NAKAMURA Ikuo , MAKABE So , KOBASHI Yuichi , MORIIZUMI Yasuhiro
摘要： An object is to provide a nucleic acid sequence modifying composition and a method for modifying a target site of a nucleic acid sequence that do not depend on a PAM sequence or a PFS sequence. The object can be achieved by a nucleic acid sequence modifying composition including RNA and a fusion protein, in which the RNA includes a hybridization region that may hybridize to a sequence on the 5' side or the 3' side of a target site of a nucleic acid sequence, and a guide region that guides the fusion protein, the guide region includes a recognition region that forms a complex with the fusion protein, and the fusion protein includes a binding domain that recognizes the recognition region of the RNA and forms a complex with the recognition region (however, it is excluded that the binding domain includes an RNA recognition region of a Cas protein group) and a modification domain that modifies the target site of the nucleic acid sequence.
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公开(公告)号：EP4396208A1
公开(公告)日：2024-07-10
申请号：EP22777533.5
申请日：2022-08-30
发明人： ARVIN, Ann M. , DI IULIO, Julia , DOUGLAS, Janet L. , MARSHALL, Emily , SORIAGA, Leah B. , VIRGIN, Herbert W.
CPC分类号： C07K14/35 , C12N9/1029 , C12N9/52 , C12R2001/3220210501 , C12N15/62 , A61K39/04 , C12N15/86 , C12N2710/1614320130101 , A61K2039/525620130101 , C07K2319/4020130101
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公开(公告)号：EP4395817A1
公开(公告)日：2024-07-10
申请号：EP22865781.3
申请日：2022-08-31
发明人： KO, Minoru S. H.
IPC分类号： A61K39/00 , C12N15/62 , C12N15/86 , A61K39/215 , A61P31/14 , C07K14/005 , C07K14/18 , C07K14/47 , C08B37/08 , A61K47/36 , A61K9/00 , A61P35/00
CPC分类号： A61P31/14 , A61P35/00 , C12N15/62 , C12N15/86 , C07K14/4748 , C07K2319/0020130101 , C07K2319/0220130101 , A61K9/0019 , C12N2770/3614320130101 , C12N15/85 , A61K2039/5120130101 , A61K39/464453 , A61K2039/5720130101 , A61K2039/7020130101 , A61K2039/5420130101 , A61K2039/54520130101 , A61K39/464488 , C12N2770/2003420130101 , A61K39/464401 , A61K39/464486 , A61K39/00
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公开(公告)号：EP4394033A1
公开(公告)日：2024-07-03
申请号：EP22860553.1
申请日：2022-08-24
发明人： LI, Linhong , ZHU, Xiangyang , LIU, Wuqing , YU, Shijun , XIN, Pengcheng , WANG, Li , YANG, Xingxing , ZHAN, Yifan , WEI, Xiaoyue
IPC分类号： C12N5/10 , C12N15/113 , C12N15/62 , A61K39/00 , A61P35/00
CPC分类号： C12N15/113 , A61P35/00 , C12N15/62 , C12N5/10 , A61K39/4631 , A61K39/4611 , A61K2239/5320230501 , A61K39/4644
摘要： Provided are a T cell product for administration to a subject and a use thereof. The product comprises at least one allogeneic T cell, the allogeneic T cell expressing at least one MHC molecule identified as an exogenous source by at least one T cell of the subject. The T cell product can widen the range of a donor and activate an immune response of the subject. Further provided is a use of the T cell product in the preparation of a drug for treating tumors.
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公开(公告)号：EP4392463A1
公开(公告)日：2024-07-03
申请号：EP22857869.6
申请日：2022-08-18
发明人： ZHU, Yanliang , JIANG, Qingling , TU, Zhongyuan , ZHANG, Yafeng , WU, Shu , FAN, Xiaohu
CPC分类号： A61P35/00 , C07K14/7051 , C12N5/0636 , C12N2510/0020130101 , C12N15/86 , C07K2319/0320130101 , C12N2740/1604320130101 , A61K39/464411 , A61K39/464429 , A61K2239/4820230501 , A61K39/464412 , A61K2239/3820230501 , A61K39/4611 , A61K39/464417 , A61K39/464402 , A61K39/464424 , A61K2239/3120230501 , A61K39/4631 , A61K2239/2920230501 , A61K2239/2620230501 , A61K39/464474
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公开(公告)号：EP4388114A1
公开(公告)日：2024-06-26
申请号：EP22859330.7
申请日：2022-08-16
IPC分类号： C12N15/87 , C12N15/63 , C12N15/62 , C12N5/0783 , C12N15/86
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