公开(公告)号：EP3246044A1

公开(公告)日：2017-11-22

申请号：EP17172800.9

申请日：2011-08-22

申请人： Wyeth LLC

发明人： KHANDKE, Lakshmi ,  ARUMUGHAM, Rasappa ,  LOUN, Bounthon

IPC分类号： A61K39/095 ,  A61K47/02 ,  A61K47/34 ,  A61K47/44 ,  G01N33/569

CPC分类号： C07K14/22 ,  A61K31/194 ,  A61K31/4172 ,  A61K38/164 ,  A61K39/095 ,  A61K2039/55505 ,  A61K2039/55555 ,  G01N33/56911

摘要： The present invention relates to stable formulations of Neisseria meningitis rLP2086 Subfamily B Antigens in immunogenic compositions. The present invention also relates to methods of preserving the conformation of Neisseria meningitis rLP2086 Antigens and methods for determining the potency of Neisseria meningitis rLP2086 antigens.

摘要翻译： 本发明涉及免疫原性组合物中脑膜炎奈瑟氏菌rLP2086亚家族B抗原的稳定制剂。 本发明还涉及保存脑膜炎奈瑟球菌rLP2086抗原构象的方法和确定脑膜炎奈瑟球菌rLP2086抗原效力的方法。

公开(公告)号：EP1562983B2

公开(公告)日：2017-11-15

申请号：EP03780528.0

申请日：2003-11-21

申请人： GlaxoSmithKline Biologicals SA

发明人： COMANDUCCI, Maurizio, Chiron Srl ,  PIZZA, Mariagrazia, Chiron Srl

IPC分类号： A61K39/095

CPC分类号： A61K39/095 ,  A61K39/102 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/575 ,  C07K14/22 ,  C07K14/285 ,  C07K2319/00

公开(公告)号：EP3229834A2

公开(公告)日：2017-10-18

申请号：EP15807865.9

申请日：2015-12-08

申请人： Sanofi Pasteur

发明人： ARNAUD-BARBE, Nadège ,  RENAULD-MONGENIE, Geneviève ,  ROKBI, Bachra

IPC分类号： A61K39/095 ,  C07K14/22

CPC分类号： A61K39/095 ,  A61K2039/575 ,  C07K14/22 ,  C07K2319/10 ,  C07K2319/21 ,  C07K2319/40 ,  C07K2319/50 ,  C12N9/52

摘要： The present invention relates to novel polypeptides derived from meningitis proteins, in particular auto-transporters of the subtilinase subclass, and their use in vaccines and vaccine compositions for the prevention and/or treatment of meningitis and meningococcal infections.

摘要翻译： 本发明涉及源自脑膜炎蛋白质，尤其是亚麻蛋白酶亚类的自动转运蛋白的新多肽，以及它们在疫苗和疫苗组合物中用于预防和/或治疗脑膜炎和脑膜炎球菌感染的用途。

公开(公告)号：EP2376112B1

公开(公告)日：2017-04-12

申请号：EP09808956.8

申请日：2009-12-11

申请人： GlaxoSmithKline Biologicals SA

发明人： CONTORNI, Mario

IPC分类号： A61K39/05 ,  A61K39/095 ,  A61K39/116 ,  A61K39/10 ,  A61P31/04

CPC分类号： A61K39/099 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/095 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  Y02A50/466

摘要： A liquid D-T-Pa component is used to reconstitute a lyophilised meningococcal component, thereby producing a combined vaccine.

公开(公告)号：EP3110442A1

公开(公告)日：2017-01-04

申请号：EP15707351.1

申请日：2015-02-27

申请人： GlaxoSmithKline Biologicals SA

发明人： BOTTOMLEY, Matthew ,  MALITO, Enrico ,  MARTINELLI, Manuele ,  SCARSELLI, Maria

IPC分类号： A61K39/095 ,  C07K14/22 ,  C07K14/095

CPC分类号： C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

摘要： Modified meningococcal fHbp polypeptides with increased stability.

摘要翻译： 修饰脑膜炎球菌fHbp多肽具有增加的稳定性。

公开(公告)号：EP2174665B1

公开(公告)日：2016-11-16

申请号：EP10001123.8

申请日：2004-10-22

申请人： ID Biomedical Corporation of Quebec

发明人： Lowell, George H. ,  Burt, David S. ,  Jones, David H. ,  Zimmermann, Joseph J. ,  Rioux, Clement

IPC分类号： A61K39/39 ,  A61K39/112 ,  A61K39/095 ,  A61P11/06 ,  A61P37/00

CPC分类号： A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/145 ,  A61K39/165 ,  A61K39/39 ,  A61K2039/55544 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/22 ,  C12N2710/24143 ,  Y02A50/394

摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.

公开(公告)号：EP1624888B1

公开(公告)日：2016-10-12

申请号：EP04751728.9

申请日：2004-05-07

申请人： Sanofi Pasteur, Inc.

发明人： RYALL, Robert, P.

IPC分类号： A61K39/095

CPC分类号： A61K39/095 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/6081

公开(公告)号：EP2184071B1

公开(公告)日：2016-08-31

申请号：EP09075005.0

申请日：2002-06-20

申请人： GlaxoSmithKline Biologicals SA

发明人： Costantino, Paolo

IPC分类号： A61K39/095 ,  A61K39/385 ,  A61P31/04 ,  C12P19/04

CPC分类号： A61K39/095 ,  A23J1/04 ,  A23J1/205 ,  A61K38/00 ,  A61K38/4893 ,  A61K39/092 ,  A61K39/102 ,  A61K39/39 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/6037 ,  C07H15/04 ,  C07K14/22 ,  C07K14/285 ,  C09F1/00 ,  C09G1/00 ,  Y02A50/466 ,  Y10S424/831

摘要： Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilisation of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide : MenC saccharide is >1.

公开(公告)号：EP2922569A4

公开(公告)日：2016-07-27

申请号：EP13856500

申请日：2013-11-18

申请人： SERUM INST INDIA LTD

发明人： SHANKAR PISAL SAMBHAJI ,  REDDY CHILUKURI SRINIVAS ,  REDDY PEDDIREDDY SRINIVAS

IPC分类号： A61K39/095 ,  C08B37/00 ,  C12P19/04

CPC分类号： C12P19/04 ,  A61K39/095 ,  C07K14/22 ,  C07K14/33 ,  C08B37/0003 ,  C08B37/0063 ,  C12N1/20 ,  C12P19/26

摘要： The instant invention provides improved culture, fermentation and purification conditions for preparing Neisseria meningitidis polysaccharides. The invention in particular relates to a novel fermentation medium, optimal feed solution addition strategies and an improved purification process devoid of any chromatographic methods for obtaining high yield of Neisseria meningitidis X polysaccharide.

公开(公告)号：EP2332961B1

公开(公告)日：2016-07-27

申请号：EP10182298.9

申请日：2002-10-11

申请人： Wyeth Holdings LLC

发明人： Zlotnick, Gary, W. ,  Fletcher, Leah, D. ,  Farley, John ,  Bernfield, Liesel, A. ,  Zagursky, Robert, J ,  Metcalf, Benjamin, J.

IPC分类号： A61K39/00 ,  C07K16/12 ,  C07K14/22 ,  G01N33/569 ,  C12N9/28 ,  A61K39/39 ,  A61K39/095 ,  C12N9/40 ,  C12N9/38 ,  A61K47/48

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.