公开(公告)号：EP1707548A1

公开(公告)日：2006-10-04

申请号：EP04807406.6

申请日：2004-12-21

申请人： Wako Pure Chemical Industries, Ltd.

发明人： ITO, Nobuhiro ,  MAESAWA, Tsuneaki ,  MUTO, Kazushige ,  HIROTA, Kosaku ,  SAJIKI, Hironao

IPC分类号： C07B59/00 ,  C07C37/00 ,  C07C39/06 ,  C07C51/00 ,  C07C57/30 ,  C07C63/04 ,  C07C211/45 ,  C07C209/00 ,  C07D213/803 ,  C07D213/74

CPC分类号： C07D213/74 ,  C07B59/00 ,  C07B2200/05 ,  C07C37/00 ,  C07C51/353 ,  C07C209/68 ,  C07D213/80 ,  C07C57/30 ,  C07C63/04 ,  C07C39/06

摘要： The subject of the present invention is to provide a method for deuteration, which can obtain a compound having an aromatic ring and/ or a heterocyclic ring at an improved deuteration ratio. The present invention relates to a method for deuteration of a compound having an aromatic ring and/or a heterocyclic ring, comprising reacting the compound having an aromatic ring and/ or a heterocyclic ring with a heavy hydrogen source in the presence of an activated mixed catalyst of not less than two kinds of catalysts selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, an iridium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.

摘要翻译： 本发明的主题是提供一种氘化方法，其可以以改进的氘化比获得具有芳环和/或杂环的化合物。 本发明涉及一种具有芳环和/或杂环的化合物的氘化方法，包括在活化的混合催化剂存在下使具有芳环和/或杂环的化合物与重氢源反应 不少于两种选自钯催化剂，铂催化剂，铑催化剂，铱催化剂，钌催化剂，镍催化剂和钴催化剂的催化剂。

公开(公告)号：EP1651590A2

公开(公告)日：2006-05-03

申请号：EP04743737.1

申请日：2004-07-19

申请人： EGIS GY GYSZERG

发明人： BARK CZY, József ,  K TAY NAGY, Péter; ,  SIMIG, Gyula ,  J KFALVI, Elemér ,  GREGORN BOROS, Livia ,  KRASZNAI, György ,  VERECZKEYN DON TH, Györgyi ,  NAGY, Kálmán ,  M METH, Norbert

IPC分类号： C07C209/00

CPC分类号： C07C211/42 ,  C07B2200/07 ,  C07C249/02 ,  C07C2602/10 ,  C07C251/20

摘要： The invention is directed to a process for the preparation of [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1-ylidene]-methyl-amine of the Formula (I) by reacting 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalene-l-one of the Formula (II) with monomethyl amine which comprises carrying out the reaction in the presence of thionyl chloride in an ether-type solvent. The [4(S,R)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalene-1-ylidene]-methyl-amine of the Formula I is a valuable pharmaceutical intermediate.

摘要翻译： 本发明涉及制备[4（S，R） - （3,4-二氯苯基）-3,4-二氢-1（2H） - 萘-1-基] - 甲基 - 胺的方法 式（I）通过式（II）的4-（3,4-二氯苯基）-3,4-二氢-1（2H）萘-1-酮与单甲基胺反应，包括在存在下进行反应 亚砜酰氯在醚类溶剂中。 式I的[4（S，R） - （3,4-二氯苯基）-3,4-二氢-1（2H） - 萘-1-亚基] - 甲基胺是有价值的药物中间体。

公开(公告)号：EP0910340A4

公开(公告)日：2004-11-17

申请号：EP97914892

申请日：1997-03-05

申请人： HYPERION CATALYSIS INT

发明人： FISCHER ALAN ,  HOCH ROBERT ,  MOY DAVID ,  LU MING ,  MARTIN MARK ,  NIU CHUN MING ,  OGATA NAOYA ,  TENNENT HOWARD ,  DONG LIWEN ,  SUN JI ,  HELMS LARRY ,  JAMEISON FABIAN ,  LIANG PAM ,  SIMPSON DAVID

IPC分类号： G01N27/30 ,  A61K33/44 ,  A61K38/00 ,  A61K39/395 ,  B01D15/08 ,  B01J20/28 ,  B01J20/32 ,  C01B31/02 ,  C07C29/16 ,  C07C29/32 ,  C07C33/18 ,  C07C51/353 ,  C07C57/40 ,  C07C57/72 ,  C07C63/44 ,  C07C209/00 ,  C07C211/57 ,  C07C233/65 ,  C07C317/12 ,  C07C319/14 ,  C07D487/22 ,  C07F1/02 ,  C07F5/00 ,  C07F7/08 ,  C07K1/107 ,  C07K17/08 ,  C08J3/12 ,  C09C1/46 ,  C12N11/02 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/37 ,  C12Q1/42 ,  C12Q1/44 ,  G01N33/543 ,  A61K9/00 ,  A01N25/00 ,  B32B5/16 ,  C09C1/56

CPC分类号： G01N33/54346 ,  B01D15/08 ,  B01D15/3804 ,  B01D15/3857 ,  B01J20/28004 ,  B01J20/28009 ,  B01J20/28014 ,  B01J20/28019 ,  B01J20/28023 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3257 ,  B01J20/3259 ,  B01J20/3261 ,  B01J20/3265 ,  B01J20/3274 ,  B01J20/3293 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/34 ,  C01B2202/36 ,  C07K1/1075 ,  C07K1/1077 ,  C09C1/46 ,  C12N11/02 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/37 ,  C12Q1/42 ,  C12Q1/44 ,  Y02P20/588

公开(公告)号：EP1230208A4

公开(公告)日：2004-09-29

申请号：EP00911452

申请日：2000-03-15

申请人： KOREA KUMHO PETROCHEM CO LTD

发明人： JOO YOUNG J ,  KIM JIN-EOK ,  WON JEONG-IM ,  HWANG KUM-UI

IPC分类号： C07C209/02 ,  C07B61/00 ,  C07C209/00 ,  C07C211/52 ,  C07C209/62

CPC分类号： C07C209/00 ,  C07C211/52

摘要： Disclosed herein is a method for preparing 4-nitrosoaniline, comprising reacting urea and nitrobenzene in a polar organic solvent in the presence of a base at a temperature of room temperature to 150 °C. The method uses a relatively cheap urea and nitrobenzene as the raw materials, and also a relatively cheap base, thereby decreasing the manufacturing cost. Urea used as an amine donor is excellent in a reactivity to nitrobenzene, and a reaction intermediate is unstable as compared with 4-(4-nitrophenyl)benzamide to easily decompose into 4-nitroaniline and 4-nitrosoaniline. This allows a reaction time and a process time to be shortened. Moreover, the method is advantageous in that waste hazardous to the environment is not produced as a byproduct.

公开(公告)号：EP1173405B1

公开(公告)日：2004-09-15

申请号：EP01906590.3

申请日：2001-01-18

申请人： BOULDER SCIENTIFIC COMPANY

发明人： SULLIVAN, Jeffrey, M. ,  RUSSO-RODRIGUEZ, Sandra

IPC分类号： C07C209/00

CPC分类号： C07C209/68 ,  C07C211/54

公开(公告)号：EP1451141A2

公开(公告)日：2004-09-01

申请号：EP02798307.1

申请日：2002-11-08

申请人： BASF AKTIENGESELLSCHAFT

发明人： STEINBRENNER, Ulrich ,  BÖHLING, Ralf ,  FUNKE, Frank ,  HARDER, Wolfgang

IPC分类号： C07C209/00 ,  C07C211/65

CPC分类号： C07C209/00 ,  C07C211/65

摘要： The present invention relates to a method for producing dialkylamides of the alkali metals by reacting the corresponding dialkylamine with the corresponding alkali metal in the presence of an electron donor substance of the group 1,3-butadiene, isoprene, naphthalene and/or styrene with the formation of low quantities of butenyl dialkylamine. According to said method, the corresponding alkali metal is introduced and suspended in a solvent and the dialkylamine and the electron donor substance are added, such that the dialkylamine is present in an amount up to 45 wt. %, preferably up to 25 wt. %, in particular up to 15 wt. % and the butadiene is present in an amount up to 5 wt. %, preferably up to 3 wt. %, in particular up to 1.5 wt. %.

公开(公告)号：EP1442006A2

公开(公告)日：2004-08-04

申请号：EP02802245.7

申请日：2002-10-28

申请人： Boehringer Ingelheim Chemicals, Inc.

发明人： BOSWELL, Robert F.,Boehringer Ingelheim Chem. Inc ,  LO, Young, S.,Boehringer Ingelheim Chemicals, Inc

IPC分类号： C07C209/00

CPC分类号： C07C209/68 ,  C07C211/27

摘要： A process for making an amphetamine from a phenylpropanolamine salt, the process comprising: (a) acylating the phenylpropanolamine salt with an acylating agent in a solvent at elevated temperature to make a reaction mixture containing an O-acylated phenylpropanolamine salt which can be isolated by the addition of a crystallization solvent, or optionally this mixture can be used in the next step; and (b) hydrogenating the O-acylated phenylpropanolamine salt to make the amphetamine in thepresence of a catalyst.

公开(公告)号：EP1422216A1

公开(公告)日：2004-05-26

申请号：EP02760710.0

申请日：2002-08-22

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： HIDAKA, Toshio, Mitsubishi Gas Chemical Co., Inc. ,  FUSHIMI, Norio, Mitsubishi Gas Chemical Co., Inc. ,  YOSHIMURA, Takafum, Mitsubishi Gas Chemical Co Inc ,  KAWAI, Takeshi, Mitsubishi Gas Chemical Co., Inc.

IPC分类号： C07C211/29 ,  C07C209/00 ,  C07C251/30 ,  C07C249/02 ,  C07B39/00 ,  C09K3/00 ,  C11D7/28

CPC分类号： C07F9/54 ,  C07B39/00 ,  C07C17/16 ,  C07C17/18 ,  C07C211/29 ,  C07C251/30 ,  C07C271/20 ,  C07F9/5004 ,  Y02P20/582

摘要： A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes.
(wherein X represents a nitrogen or phosphorus atom; R 0 , R 1 , and R 2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R 0 , R 1 , and R 2 may be combined with each other to form a ring).

摘要翻译： 提供由式（1）表示的氟化合物。 上述氟化合物有效地将氟原子引入具有活性基团的化合物如含氧官能团，并且可用于表面处理，清洁和涂覆。 此外，在氟化反应之后，回收上述化合物，并且可以重新使用作为制备上述氟化合物的原料，并且其可用于各种氟化方法。 （其中X表示氮或磷原子; R 0，R 1和R 2表示氢，可以具有取代基的烷基或芳基，它们各自可以相同或不同; R 0，R 1和 R2可以彼此组合以形成环）。

公开(公告)号：EP1353746A2

公开(公告)日：2003-10-22

申请号：EP01994467.7

申请日：2001-12-20

申请人： CORNING INCORPORATED

发明人： LETOURNEUR, Didier ,  SORENSEN, JR., Charles M ,  WOEHL, Pierre

IPC分类号： B01J8/04 ,  C07C5/02 ,  C07C17/00 ,  C07C201/06 ,  C07C209/00

CPC分类号： B01J4/001 ,  B01J19/2485 ,  B01J35/04 ,  B01J2219/0004 ,  B01J2219/00164 ,  Y10S585/926

摘要： A method is disclosed for maintaining a volumetric gas to liquid ratio in a segmented gas/liquid flow along a reactor of monolithic catalyst beds in series. The present invention includes the steps of: initiating the segmented gas/liquid flow at a first end of the reactor by introducing feed liquid and feed gas both at a predetermined volume and a predetermined flow rate; injecting an additional amount of gas at least once into any of the spaces between catalyst beds; and combining the segments of the segmented gas/liquid flow at a second end of the reactor. The injection of gas is controlled such that the segmented gas/liquid flow can be maintained near or at the Taylor regime.

公开(公告)号：EP1294675A2

公开(公告)日：2003-03-26

申请号：EP01946568.1

申请日：2001-06-20

申请人： FLEXSYS AMERICA L.P.

发明人： DE VERA, Antonio, L. ,  RAINS, Roger, Keranan

IPC分类号： C07C209/00 ,  C07C209/36 ,  C07C211/55 ,  C07C209/02 ,  B01J29/04 ,  B01J29/40 ,  B01J29/85 ,  B01J31/02

CPC分类号： C07C209/36 ,  B01J29/40 ,  B01J29/44 ,  B01J31/0239 ,  B01J31/0254 ,  B01J2229/26 ,  B01J2229/42 ,  B01J2531/985 ,  C07C211/51 ,  C07C211/55

摘要： This invention provides a composition suitable for use in a reaction zone where aniline is reacted with nitrobenzene to obtain intermediates of 4-amino-diphenylamine comprising a solide support having interior channels with base material employed in the reaction loaded into the channels. The cross-sectional dimensions of the channels are such as to provide a restricted transition state with regard to the reaction and to improve the selectivity of the reaction in favor of the intermediates The invention also provides a method for loading the base material in the solid support. The invention further provides a process for carrying out the above reaction using the above composition.