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31.发明公开4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS 审中-公开作为TRPM8拮抗剂的4-羟基-2-苯基-1,3-噻唑-5-基甲酮衍生物
公开(公告)号：EP3184524A1
公开(公告)日：2017-06-28
申请号：EP15201788.5
申请日：2015-12-21
IPC分类号： C07D417/06 , C07D277/56 , A61P29/00 , A61K31/381 , A61K31/4025 , A61K31/5355 , A61K31/5377 , A61K31/4436 , A61K31/4535 , A61K31/4155 , A61P11/00 , A61P13/00
CPC分类号： C07D417/06 , C07D277/56
摘要： The invention relates to compounds acting as antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I):
Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold-induced and/or exacerbated- respiratory disorders, urological disorders, corneal disordes associated to disturbances in the production of the tears and/or altered blinking such as epiphora and dry eye disease.摘要翻译： 本发明涉及作为瞬时受体电位阳离子通道亚家族M成员8（TRPM8）的拮抗剂并具有式（I）的化合物：所述化合物可用于治疗与TRPM8活性相关的疾病，例如疼痛，局部缺血，神经变性 ，中风，精神病，瘙痒，肠易激综合征，冷诱导和/或恶化 - 呼吸系统疾病，泌尿系统疾病，与眼泪产生紊乱相关的角膜紊乱和/或眨眼和眼睑疾病等眨眼改变。
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32.发明公开2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA 审中-公开2-芳基-4-羟基-1,3-噻唑FOR USE AS TRPM8抑制剂作者神经痛，疼痛，慢性阻塞性肺病和哮喘于治疗
公开(公告)号：EP3157918A1
公开(公告)日：2017-04-26
申请号：EP15730801.6
申请日：2015-06-23
发明人： ARAMINI, Andrea , BIANCHINI, Gianluca , BRANDOLINI, Laura , BECCARI, Andrea , LILLINI, Samuele , NANO, Giuseppe
IPC分类号： C07D417/04 , C07D263/42 , A61K31/426 , A61P29/00
CPC分类号： C07D277/34 , C07D263/42 , C07D417/04
摘要： Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
摘要翻译： 在本发明涉及化合物作用瞬时受体电位阳离子通道亚家族中号构件8（TRP.M8）的选择性拮抗剂，和具有式（I）。 所述化合物可与TRPM8的活性相关的疾病的治疗有用：如疼痛，炎症，局部缺血，神经变性，中风，精神疾病，瘙痒，过敏性肠疾病，冷诱导的和/或加重的呼吸障碍和泌尿疾病。
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33.发明授权(R)-ARYLKYLAMINO DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权（R）-ARYLALKYLAMINODERIVATE和药物组合物含
公开(公告)号：EP1951663B1
公开(公告)日：2016-07-20
申请号：EP06819736.7
申请日：2006-11-24
发明人： ALLEGRETTI, Marcello , MORICONI, Alessio , ARAMINI, Andrea , CESTA, Maria Candida , BECCARI, Andrea , BERTINI, Riccardo
IPC分类号： C07C309/65 , C07C311/03 , C07C311/21 , C07C233/76 , C07D213/70 , C07D213/76 , C07D277/42 , C07D295/10 , C07D295/14 , C07D307/52 , C07D307/68 , C07D333/34 , A61K31/18 , A61K31/165 , A61P9/10
CPC分类号： C07C311/21 , C07C233/76 , C07C309/65 , C07C311/03 , C07D213/70 , C07D213/76 , C07D277/42 , C07D295/108 , C07D295/15 , C07D307/52 , C07D307/68 , C07D333/34
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公开(公告)号：EP3735227A1
公开(公告)日：2020-11-11
申请号：EP19700330.4
申请日：2019-01-03
IPC分类号： A61K9/20 , A61K31/192 , A61K31/205
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公开(公告)号：EP3700514A1
公开(公告)日：2020-09-02
申请号：EP18795414.4
申请日：2018-10-23
IPC分类号： A61K31/165 , A61K31/19 , A61K31/426 , A61P35/04 , A61P35/00
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36.发明公开
公开(公告)号：EP3670489A1
公开(公告)日：2020-06-24
申请号：EP18215336.1
申请日：2018-12-21
摘要： The present invention refers to a co-crystal of Ketoprofen lysine, a pharmaceutical composition comprising said co-crystal, a process for its production and to its use in the treatment of pain and inflammatory diseases.
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公开(公告)号：EP3508199A1
公开(公告)日：2019-07-10
申请号：EP18150490.3
申请日：2018-01-05
IPC分类号： A61K9/20 , A61K31/192 , A61K31/205
摘要： The present invention in general relates to an immediate-release pharmaceutical composition containing ketoprofen lysine salt and mannitol. In particular, the present invention relates to an immediate-release pharmaceutical composition in the form of tablet. The invention also provides a process for manufacturing such composition.
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38.发明公开
公开(公告)号：EP3402474A1
公开(公告)日：2018-11-21
申请号：EP17701646.6
申请日：2017-01-13
IPC分类号： A61K31/165 , A61K31/19 , A61P25/02
CPC分类号： A61K31/165 , A61K31/19
摘要： The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1 /CXCR2 receptor inhibitors, useful in the treatment and/or prevention of chemotherapy-induced neuropathy, preferably in the treatment and/or prevention of chemotherapy-induced peripheral neuropathy (CIPN) or chemotherapy-induced optic neuropathy.
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公开(公告)号：EP3342407A1
公开(公告)日：2018-07-04
申请号：EP17150176.0
申请日：2017-01-03
发明人： ALLEGRETTI, Marcello , ARAMINI, Andrea , CESTA, Maria, Candida , BIANCHINI, Gianluca , BRANDOLINI, Laura
IPC分类号： A61K31/255 , A61K31/421 , A61K31/427 , A61P13/08
CPC分类号： A61K31/427 , A61K31/255 , A61K31/421
摘要： The present invention relates to IL-8 inhibitor compounds for use in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and benign prostatic hyperplasia.
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公开(公告)号：EP2793883B1
公开(公告)日：2018-04-18
申请号：EP12812229.8
申请日：2012-12-19
发明人： MORICONI, Alessio , BIANCHINI, Gianluca , COLAGIOIA, Sandro , BRANDOLINI, Laura , ARAMINI, Andrea , LIBERATI, Chiara , BOVOLENTA, Silvia
IPC分类号： A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , C07D263/40 , C07D263/48 , C07D277/34 , C07D277/42 , C07D277/56 , C07D417/02 , C07D413/02 , C07D403/02 , A61P29/00 , A61K31/4245 , A61K31/4439 , A61K31/472 , C07D417/04 , C07D417/10 , C07D417/12 , C07D263/42 , C07D413/04
CPC分类号： C07D417/12 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/472 , C07D263/40 , C07D263/42 , C07D277/56 , C07D413/04 , C07D417/04 , C07D417/10
摘要： The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exhacerbated respiratory disorders and urological disorders.
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