公开(公告)号：EP1624873A2

公开(公告)日：2006-02-15

申请号：EP04729952.4

申请日：2004-04-28

申请人： AB Science

发明人： KINET, Jean-Pierre ,  MOUSSY, Alain

IPC分类号： A61K31/506 ,  A61K31/496 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/4545 ,  A61P25/28

CPC分类号： A61K31/506 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377

摘要： The present invention relates to a method for treating cerebral ischemia, comprising administering a compound capable of depleting mast cells or a compound inhibiting mast cells degranulation to a human in need of such treatment. Such compounds can be chosen from tyrosine kinase inhibitors and more particularly non-toxic, selective and potent c-kit inhibitors. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1450775A2

公开(公告)日：2004-09-01

申请号：EP02775081.9

申请日：2002-09-20

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/00 ,  A61K31/404 ,  A61K31/506 ,  A61K31/505 ,  A61K31/519 ,  A61K31/517 ,  A61K31/498 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/015 ,  A61K31/095 ,  A61K31/66 ,  A61P31/04

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/015 ,  A61K31/095 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  G01N33/5047 ,  G01N33/56911 ,  G01N2333/70596 ,  Y02A50/473 ,  Y02A50/481 ,  A61K2300/00

摘要： The present invention relates to a method for treating bacterial infections, preferably infections caused by FimH expressing bacteria, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non toxic, potent and selective c-kit inhibitor, wherein said inhibitor is unable to promote detah of IL-3 dependent cells cultured to presence of IL-3.

公开(公告)号：EP1427422A1

公开(公告)日：2004-06-16

申请号：EP02777611.1

申请日：2002-09-20

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/506 ,  A61P17/00 ,  A61P35/00 ,  A61P43/00 ,  A61K7/48

CPC分类号： A61K8/492 ,  A61K8/4953 ,  A61K31/506 ,  A61K2800/782 ,  A61Q19/02

摘要： The present invention relates to a method for whitening human skin and treating melanocyte dysfunction associated diseases comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1401413A2

公开(公告)日：2004-03-31

申请号：EP02755512.7

申请日：2002-06-28

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/00 ,  A61K31/404 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/517

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/015 ,  A61K31/095 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/66 ,  G01N2333/70596 ,  A61K2300/00

摘要： The present invention relates to a method for treating allergic diseases such as asthma, comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP1401412A2

公开(公告)日：2004-03-31

申请号：EP02755510.1

申请日：2002-06-28

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/00

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/015 ,  A61K31/095 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  G01N33/5047 ,  G01N2333/70596 ,  A61K2300/00

摘要： The present invention relates to a method for inhibiting tumor angiogenesis comprising administering a c-kit inhibitor to a human in need of such treatment, more particularly a non toxic, potent and selective c-kit inhibitor, wherein said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

公开(公告)号：EP4262801A1

公开(公告)日：2023-10-25

申请号：EP21839188.6

申请日：2021-12-16

申请人： AB Science

发明人： MOUSSY, Alain ,  MANSFIELD, Colin

IPC分类号： A61K31/496 ,  A61P25/28

公开(公告)号：EP4132528A1

公开(公告)日：2023-02-15

申请号：EP21717452.3

申请日：2021-04-09

申请人： AB Science ,  The University of Chicago

发明人： MOUSSY, Alain ,  TAY, Savas ,  DRAYMAN, Nir ,  RANDALL, Glenn ,  CHEN, Siquan

IPC分类号： A61K31/496 ,  A61P31/00 ,  A61P31/14 ,  A61K31/352

公开(公告)号：EP3368032A1

公开(公告)日：2018-09-05

申请号：EP16794960.1

申请日：2016-10-28

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre ,  MANSFIELD, Colin

IPC分类号： A61K31/352 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/519 ,  A61K31/661 ,  A61P25/16

CPC分类号： A61K31/496 ,  A61K31/352 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/519 ,  A61K31/661 ,  A61K45/06 ,  A61P25/16

摘要： Disclosed is a mast cell inhibitor, a pharmaceutical composition and a method for the treatment of patients afflicted with Parkinson's disease, wherein the patients are treated with a tyrosine kinase inhibitor or mast cell inhibitor, in particular masitinib, or a compound selected from imatinib, cromolyn sodium, midostaurin, BLU-285, bosutinib, ibrutinib, LAS189386, DP-2618, fostamatinib, dasatinib, sunitinib, axitinib, pazopanib, and toceranib or a pharmaceutically acceptable salt or solvate thereof, optionally in combination with at least one pharmaceutically active ingredient.

公开(公告)号：EP2117531B1

公开(公告)日：2016-11-02

申请号：EP08707865.5

申请日：2008-01-11

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/337 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/7068 ,  A61P35/00

CPC分类号： A61K31/426 ,  A61K31/337 ,  A61K31/421 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/7068 ,  A61K2300/00

公开(公告)号：EP3053920A1

公开(公告)日：2016-08-10

申请号：EP15154028.3

申请日：2015-02-05

申请人： AB Science

发明人： Moussy, Alain ,  Benjahad, Abdellah ,  Pez, Didier ,  Sandrinelli, Franck ,  Martin, Jason ,  Picoul, Willy ,  Chevenier, Emmanuel

IPC分类号： C07D413/14 ,  C07D413/10 ,  C07D417/10 ,  A61K31/439 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4196 ,  A61K31/4192 ,  A61K31/427 ,  A61P35/00

摘要： The present invention relates to compounds of general formula (I).

wherein A represents an optionally substituted heterocyclyl group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases

摘要翻译： 本发明涉及通式（I）的化合物。 其中A表示任选取代的杂环基，B表示芳基或杂芳基，其中X，R 1，R 2，R 3，R 4和R 5如说明书中所定义。 式（I）化合物可用于破坏，抑制或预防细胞，特别是恶性细胞生长或扩散到涉及各种人和动物疾病的周围组织中