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41 条记录 (耗时 0.01 秒)

    Fungal resistance markers
    31.
    发明公开
    Fungal resistance markers 失效
    Pilzresistente Markierungsmaterialien。

    公开(公告)号：EP0240250A1

    公开(公告)日：1987-10-07

    申请号：EP87302632.2

    申请日：1987-03-26

    申请人： Antibioticos, S.A.

    发明人： Sanchez, Florentina Sanchez ,  Susan, Victor Rubio ,  Carramolino-Fitera, Laura ,  Ortega, Agustin Perez Aranda

    IPC分类号： C12N15/52 ,  C12N15/53 ,  C12N15/80

    CPC分类号： C12N9/0028 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/80 ,  Y10S435/911 ,  Y10S435/933 ,  Y10S435/935

    摘要： A drug resistant strain of P.chrysogenum has said drug resistance conferred by heterologuns DNA, in particular a heterologous gene(s) under the control of a Penicillium control sequence(s). Drug resistance is especially to sulpho- nomides, or to trimethoprim or methotrexate by a gene derived from plasmid R388. A vector capable of conferring resistance to methotrexate or sulphonamide on P.chrysogenum, comprises at least one said resistance gene under the control of trpc controlling sequences.

    摘要翻译： 金黄色葡萄球菌的耐药株具有由异源DNA提供的耐药性，特别是在青霉属对照序列的控制下的异源基因。 耐药性特别是通过源自质粒R388的基因对磺酰胺或甲氧苄氨嘧啶或甲氨蝶呤。 能够产生对产黄青霉的甲氨蝶呤或磺胺的抗性的载体包含至少一个在trpC控制序列控制下的所述抗性基因。

    A process for the preparation of sodium amoxycillin
    33.
    发明公开
    A process for the preparation of sodium amoxycillin 失效
    一种用于阿莫西林钠的制备方法。

    公开(公告)号：EP0220925A1

    公开(公告)日：1987-05-06

    申请号：EP86308187.3

    申请日：1986-10-21

    申请人： Antibioticos, S.A.

    发明人： Perez-Aranda Ortega, Augustin ,  Conde Ruzafa, Santiago ,  Roncal Serra, Fernando

    IPC分类号： C07D499/16

    CPC分类号： C07D499/00

    摘要： Sodium amoxycillin, of use for example by parenteral administration, is prepared by:

    (a) suspending amoxycillin trihydrate in a mixture consisting of an aprotic organic solvent and a lower alcohol;
    (b) solubilising the amoxycillin trihydrate by the addition of a low molecular weight amine of the group of cyclic or heterocyclic aliphatics;
    (c) adding to such solution the sodium salt of diethyloxalacetic acid or the sodium salt of 2-ethylhexanoic acid, agitating the reaction mixture at a temperature of from -10°C to ambient temperature and finally isolating the sodium amoxycillin by filtration after its precipitation in the reaction medium by the addition of an aprotic organic solvent.

    Shuttle vector
    35.
    发明公开
    Shuttle vector 失效
    Pendelvektor。

    公开(公告)号：EP0178744A2

    公开(公告)日：1986-04-23

    申请号：EP85302186.3

    申请日：1985-03-28

    申请人： Antibioticos, S.A.

    发明人： Sanchez, Flora ,  Garcia, Jose Luis ,  Penalva, Miguel A. ,  Marquez, Gabriel ,  Tourino, Angeles ,  Rubio, Victor

    IPC分类号： C12N15/00

    CPC分类号： C12N15/77 ,  C12N15/75

    摘要： 57 A plasmid such as the plasmid pFJ1 shown in the drawing and contained in Bacillus subtilis NCIB 12020 or Brevibacterium lactofermentum NCIB 12021 or Escherichia coli NCIB 12023 is capable of autonomous replication in microorganisms belonging to the genus Corynebacterium or the genus Brevibacterium and also in the species Bacillus subtilis and Escherichia coli.

    摘要翻译： 包含在枯草芽孢杆菌NCIB 12020或乳发酵短杆菌NCIB 12021或大肠杆菌NCIB 12023中的质粒如图中所示的质粒pFJ1能够在属于棒杆菌属或短杆菌属的微生物中以及在芽孢杆菌属物种中能够自主复制 枯草芽孢杆菌和大肠杆菌。

    Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
    36.
    发明公开
    Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid 失效
    Verfahren zur Isolierung eines pharmazeutischverträglichenAlkalmetallsalzes derClavulansäure

    公开(公告)号：EP0867515A1

    公开(公告)日：1998-09-30

    申请号：EP97104947.3

    申请日：1997-03-24

    申请人： CIPAN-Companhia Industrial Produtora De Antibioticos, S.A.

    发明人： Cardoso, Jaoquim P.

    IPC分类号： C12P17/18 ,  C07D503/00

    CPC分类号： C07D503/00 ,  C12P17/188

    摘要： The invention relates to the process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid from a fermentation broth containing impure clavulanic acid comprising the steps of filtration of the fermented broth, extraction of the clavulanic acid to a water immiscible or partly water immiscible solvent at pH from 1.2 - 2, precipitation of an alkali metal salt A of clavulanic acid by addition of a solution of an alkali metal alkylalkanoate, characterized by the following steps:

    before the filtration the fermented broth containing clavulanic acid is diluted with water, a flocculating agent is added and the pH is adjusted to 3 - 5
    for further purification the alkali metal salt A of clavulanic acid is converted to clavulanic acid by addition of an inorganic acid and is extracted into a water immiscible or partly water immiscible solvent
    a solution of a different alkali metal B alkyl alkanoate is added and the alkali metal salt B of clavulanic acid is precipitated.

    摘要翻译： 本发明涉及从含有不纯的克拉维酸的发酵液中分离可药用的克拉维酸碱金属盐的方法，包括以下步骤：过滤发酵肉汤，将克拉维酸萃取到与水不混溶或部分与水不混溶的水 溶剂，pH为1.2-2，通过加入碱金属烷基链烷酸酯的溶液沉淀棒酸的碱金属盐A，其特征在于以下步骤：在过滤之前，将含有克拉维酸的发酵肉汤用水稀释， 加入絮凝剂并将pH调节至3-5以进一步纯化，通过加入无机酸将克拉维酸的碱金属盐A转化为克拉维酸，并将其萃取到水不混溶或部分与水不混溶的溶剂中， 加入不同的碱金属B烷基链烷酸酯，并且克拉维酸的碱金属盐B沉淀 ated。

    ALTERNATIVE PROCESS FOR PRODUCING 6-AMINO-PENICILLANIC ACID (6-APA)
    37.
    发明公开
    ALTERNATIVE PROCESS FOR PRODUCING 6-AMINO-PENICILLANIC ACID (6-APA) 失效
    中世纪VERFAHREN ZUR HERSTELLUNG VON 6-AMINOPENICILLANSÄURE

    公开(公告)号：EP0826776A1

    公开(公告)日：1998-03-04

    申请号：EP97908295.5

    申请日：1997-03-14

    申请人： Antibioticos, S.A.

    发明人： OLIVER RUIZ, Manuel ,  FRAILE YECORA, Nieves ,  GONZALEZ DE PRADO, Emiliano ,  VITALLER ALBA, Alejandro ,  SALTO MALDONADO, Francisco

    IPC分类号： C12P37/06 ,  C07D499/18

    CPC分类号： C12P37/06 ,  B01D61/142

    摘要： Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultrafiltration of the culture broth in at least 2 successive stages. The first stage has a cut-off for molecular weights of 20,000 Dalton and the second, 2000 Dalton. Subsequent to the enzyme conversion stage the products from that stage are subjected to a series of anionic exchange chromatography steps.

    摘要翻译： 获得6-氨基青霉烷酸的替代方法。 该方法包括用有机溶剂代替提取阶段，并通过培养液在至少2个连续阶段的超滤过程将中间体青霉素盐作为固体进行分离和分离。 第一阶段的分子量为20,000道尔顿，第二级为2000道尔顿。 在酶转化阶段之后，对来自该阶段的产物进行一系列阴离子交换色谱步骤。