中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

44 records (took 0.028 seconds)

    IN SITU METHOD OF ANALYZING CELLS
    33.
    发明公开
    IN SITU METHOD OF ANALYZING CELLS 审中-公开
    原位方法进行基因分析

    公开(公告)号：EP1100966A1

    公开(公告)日：2001-05-23

    申请号：EP99935853.4

    申请日：1999-07-23

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： McNAMARA, George ,  SOENKSEN, Dirk ,  CABIB, Dario ,  BUCKWALD, Robert

    IPC: C12Q1/68

    CPC classification number: G01J3/457 ,  G01J3/2823 ,  G01J2003/2866 ,  G01N33/5005 ,  G01N33/56966

    Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected such that a spectral component associated with each of the N stains is collectable.

    Methods and apparati for spectral imaging using interferometers of the Fabry-Perot type
    36.
    发明公开
    Methods and apparati for spectral imaging using interferometers of the Fabry-Perot type 失效
    方法和装置用于光谱成像由法布里 - 珀罗干涉仪的装置

    公开(公告)号：EP0957345A3

    公开(公告)日：2000-05-03

    申请号：EP99111903.3

    申请日：1993-07-22

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Cabib, Dario ,  Friedman, Zvi ,  Lipson, Stephen G. ,  Buckwald Robert A.

    IPC: G01J3/28

    CPC classification number: G01J3/2823 ,  G01J3/26 ,  G01J2003/2866

    Abstract: A method and an apparatus of analyzing an optical image of a scene to determine the spectral intensity of each pixel thereof, comprising: collecting incident light from the scene; passing the light through an interferometer which outputs modulated light corresponding to a predetermined set of linear combinations of the spectral intensity of the light emitted from each pixel; focusing the light outputted from the interferometer on a two dimensional detector array; and processing the output of the detector array to determine the spectral intensity of each pixel thereof; the interferometer being of the low-finesse translating Fabry-Perot type in which the optical path difference is varied to modulate the light by translating an element of the interferometer, such that at each instant each detector sees a different point of the scene.

    Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardware therefor
    37.
    发明公开
    Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardware therefor 无效
    用于通过多个宽带滤光器的装置的图像元素分类为根据它们的光谱组的方法和装置

    公开(公告)号：EP0899558A3

    公开(公告)日：1999-09-29

    申请号：EP98306743.0

    申请日：1998-08-24

    Applicant: Applied Spectral Imaging Ltd.

    Inventor： Katzir, Nir ,  Garini, Yuval ,  Wine, David ,  Cabib, Dario

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  G01N15/1475 ,  G01N21/6458 ,  G01N2021/6441 ,  G02B21/06

    Abstract: A method of classification of pixels into groups of pixels according to their association with a single fluorophore or a combination of fluorophores selected from a plurality of fluorophores, each of the fluorophores having characterizing excitation and emission spectra and specifying excitation and emission peaks, the method comprising the steps of (a) providing a plurality of pairs of wide-band excitation filters (114) and wide-band emission filters (116); (b) exciting fluorophores of each of the pixels with light filtered through one of the wide-band excitation filters, and recording emitted light intensity (122) as retrieved after passing through its paired emission filter; (c) repeating step (b) for all of the plurality of pairs of filters, such that each of the pixels is representable by a vector of a plurality of dimensions, the number of dimensions being equal to the number of the plurality of pairs of filters; (d) using an algorithm for evaluating the presence of each of the plurality of fluorophores in each of the pixels, thereby classifying each of the pixels into a group of pixels according to its association with a single fluorophore or combination of fluorophores.

Patent Agency Ranking