摘要:
The invention provides compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compouds.
摘要:
The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.
摘要:
The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists, antagonists or mixed agonists / antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds.
摘要:
The present invention relates to 2-amine-4-oxo-quinazolines which bind to the LXR receptors and act as agonists and antagonists of the LXR receptors. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds. In particular the compounds are useful in the treatment of hypercholesterolemia, obesity or other diseases associated with elevated lipoprotein (LDL) levels.
摘要:
The invention provides a method for establishing or modifying a data source comprising a plurality of entries related to biological sequences that are non-redundant with regard to said sequences on the basis of a plurality of data sets of one or more basic data sources, each of said data sets comprising a biological sequence, said method comprising the steps of:
retrieving for one or more data sets a biological sequence contained in the data set and generating a hash key from the biological sequence thus retrieved by applying a collision-free hash function, said hash function mapping the data representing said sequence onto a message of a length shorter than the length of the original data representing the sequence, for each of said data sets, adding information for retrieving information from said data set to an entry in a reference data source uniquely related to the hash key generated from said sequence contained in said data set, wherein a new entry in said reference data source is provided which comprises one unique hash key and information for retrieving the data set or data sets comprising the sequence from which said hash key was generated, if said reference data source does not comprise an entry related to said hash key, such that each entry in said reference data source is uniquely identified by a hash key generated from a sequence. The invention also relates to a corresponding computer system and a method of updating a non-redundant data source using a reference data source.
摘要:
The invention relates to a method for passing information between different applications running on one or more computers comprising the following steps: providing output information from a source application, passing said output information to an intermediate application, establishing, in said intermediate application, input information for a target application that is related to the output information of said source application by a predetermined rule, passing said input information to said target application and inputting said input information to said target application, and to a related computer system.
摘要:
The present invention relates to novel bicyclic hydantoin derivative compounds of the following formula (I): wherein R1 to R5 and n have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing bicyclic hydantoin derivative compounds.
摘要:
The invention relates to a method for the preferential nucleic acid synthesis reaction of one or more selected regions of one or more target nucleic acids form a group of at least two different target nucleic acids comprising the steps of combining in a reaction mixture necessary reagents, additionally, adding at least two different target nucleic acid molecules together with at least one blocking agent, which is capable of binding at least one of the nucleic acid template molecules in a sequence specific manner, in such a way that the polymerase is not able to utilize the bound target nucleic acid molecule as a template and, exposing the reaction mixture to a temperature at which nucleic acids may be synthesized by the polymerase. Additionally, the invention relates to uses of the method, such as for creating mRNA or other clone libraries as well as kits for performing the method.
摘要:
The invention provides a method of structuring a set of signals representing biological, chemical and/or physical data, especially data related to the structure of biomolecules, according to predetermined patterns by means of an apparatus for processing said signals, especially patterns forming a hierarchy, wherein a pattern of a higher order comprises at least one pattern of a lower order, said method comprising the steps of:
providing a set of signals, comparing a group of signals forming part of said set to one or more predetermined patterns by means of said processing apparatus, if a match is found, modifying said set of signals by said processing apparatus, said step of modifying said set comprising the step of replacing the group of signals matching the pattern by a unit of signals, said unit having an order corresponding to the order of the matching pattern and comprising information on the signals comprised in said unit.
摘要:
Process for the determination of interacting biomolecules wherein a) a first group is provided comprising sequences representing homologous biomolecules, b) at least one second group is provided comprising sequences representing homologous biomolecules, c) group correlation values between the sequences of the first group and the sequences of at least one second group are determined, and d) the probability of the interaction of the sequence represented biomolecules is determined on the basis of the group correlation values.