2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds
    34.
    发明公开
    2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds 审中-公开
    2-氨基-4-氮杂环丁酮,死于LXR Kernrezeptor binden

    公开(公告)号:EP1407774A1

    公开(公告)日:2004-04-14

    申请号:EP02020255.2

    申请日:2002-09-10

    摘要: The present invention relates to 2-amine-4-oxo-quinazolines which bind to the LXR receptors and act as agonists and antagonists of the LXR receptors. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and the production of medicaments using said compounds. In particular the compounds are useful in the treatment of hypercholesterolemia, obesity or other diseases associated with elevated lipoprotein (LDL) levels.

    摘要翻译: 2-氨基-4-喹唑啉酮衍生物(I)及其盐是新的。 式(I)的2-氨基-4-喹唑啉酮衍生物及其盐是新的。 羧酸,羧甲基,羟甲基,氨基,(单取代的)氨基,OH,甲酰胺,N-甲基吗啉, (1-6C烷基)甲酰胺(全部任意保护),N,N-二(1-6C烷基)甲酰胺,三氟甲基,N - ((1-6C烷基)磺酰基)氨基,N-(苯基磺酰基)氨基, 卤素,氰基,硝基-17C酰氧基或(二取代的)氨基; R5H,1-8C烷基(任选取代的),7-12C烷基苯基或7-12C取代的苯基烷基; R6H,1-8C烷基,1-8C取代的烷基,7-12C烷基苯基或7-12C取代的苯基烷基; 和R7H,1-8C烷基(任选取代的),7-12C烷基苯基或7-12C取代的苯基烷基活性:厌氧。 肝脏X受体(LXR)(核受体)激动剂。 (1)评估其在HEK293细胞中介导LXR介导转录的反式激活的活性。 观察到LXRa的中位有效浓度为3微摩尔报道基因的剂量依赖性反式激活。

    Method and apparatus for combining data of biological sequences into a non-redundant data source
    35.
    发明公开
    Method and apparatus for combining data of biological sequences into a non-redundant data source 审中-公开
    用于生物序列的数据组合到一个非冗余数据源的方法和装置

    公开(公告)号:EP1387292A1

    公开(公告)日:2004-02-04

    申请号:EP02016796.1

    申请日:2002-07-26

    发明人: Ohr, Christian

    IPC分类号: G06F17/30 G06F19/00

    CPC分类号: G06F17/30949 G06F19/28

    摘要: The invention provides a method for establishing or modifying a data source comprising a plurality of entries related to biological sequences that are non-redundant with regard to said sequences on the basis of a plurality of data sets of one or more basic data sources, each of said data sets comprising a biological sequence, said method comprising the steps of:

    retrieving for one or more data sets a biological sequence contained in the data set and generating a hash key from the biological sequence thus retrieved by applying a collision-free hash function, said hash function mapping the data representing said sequence onto a message of a length shorter than the length of the original data representing the sequence,
    for each of said data sets, adding information for retrieving information from said data set to an entry in a reference data source uniquely related to the hash key generated from said sequence contained in said data set, wherein a new entry in said reference data source is provided which comprises one unique hash key and information for retrieving the data set or data sets comprising the sequence from which said hash key was generated, if said reference data source does not comprise an entry related to said hash key,
    such that each entry in said reference data source is uniquely identified by a hash key generated from a sequence.
    The invention also relates to a corresponding computer system and a method of updating a non-redundant data source using a reference data source.

    摘要翻译: 本发明提供了一种用于建立或修改数据源包括与生物序列条目的多元性没有非冗余关于所述序列的数据组中的一个或多个基本的数据源,每一个的多个的基础上 所述数据集包含生物序列,所述方法包括以下步骤:检索一个或多个数据集包含在所述数据中的生物序列设置,并产生从生物序列的散列密钥通过施加一个无碰撞散列函数。因此检索 所述散列函数映射表示所述序列到长度比表示的序列的原始数据,对每个所述数据集的长度更短的消息中的数据,用于检索从所述数据组的信息,以一个基准数据的条目信息中添加 源唯一地涉及从包含在所述数据集的所述序列生成的散列密钥,worin在所述参考数据源是新条目 提供了包含用于检索所述数据集或数据集,其包含序列从其中所述散列密钥产生,如果所述基准数据源不包括与该散列密钥的条目一个唯一的哈希键和信息,审查的确在所述每个条目 基准数据源唯一地由从一个序列生成的哈希关键字标识。 因此,本发明涉及相应的计算机系统和更新使用参考数据源的非冗余数据源的方法。

    METHOD AND APPARATUS FOR PASSING INFORMATION BETWEEN APPLICATIONS ON A COMPUTER SYSTEM
    36.
    发明公开
    METHOD AND APPARATUS FOR PASSING INFORMATION BETWEEN APPLICATIONS ON A COMPUTER SYSTEM 审中-公开
    方法和设备的应用程序之间对一个计算机系统的信息交流

    公开(公告)号:EP1364304A2

    公开(公告)日:2003-11-26

    申请号:EP01978425.5

    申请日:2001-10-16

    IPC分类号: G06F17/00

    CPC分类号: G06F17/3089

    摘要: The invention relates to a method for passing information between different applications running on one or more computers comprising the following steps: providing output information from a source application, passing said output information to an intermediate application, establishing, in said intermediate application, input information for a target application that is related to the output information of said source application by a predetermined rule, passing said input information to said target application and inputting said input information to said target application, and to a related computer system.

    Method of blocking amplification of selected sequences
    38.
    发明公开
    Method of blocking amplification of selected sequences 审中-公开
    Verfahren zur Blockierung der Amplifizierung vonausgewähltenSequenzen

    公开(公告)号:EP1253205A1

    公开(公告)日:2002-10-30

    申请号:EP01109971.0

    申请日:2001-04-24

    IPC分类号: C12Q1/68 C12N15/10

    摘要: The invention relates to a method for the preferential nucleic acid synthesis reaction of one or more selected regions of one or more target nucleic acids form a group of at least two different target nucleic acids comprising the steps of combining in a reaction mixture necessary reagents, additionally, adding at least two different target nucleic acid molecules together with at least one blocking agent, which is capable of binding at least one of the nucleic acid template molecules in a sequence specific manner, in such a way that the polymerase is not able to utilize the bound target nucleic acid molecule as a template and, exposing the reaction mixture to a temperature at which nucleic acids may be synthesized by the polymerase. Additionally, the invention relates to uses of the method, such as for creating mRNA or other clone libraries as well as kits for performing the method.

    摘要翻译: 本发明涉及一种或多种靶核酸的一个或多个选定区域的优先核酸合成反应形成一组至少两种不同靶核酸的方法,所述方法包括以下步骤:在反应混合物中混合所需的试剂,另外 将至少两种不同的靶核酸分子与至少一种能够以序列特异性方式结合至少一种核酸模板分子的封闭剂,使聚合酶不能利用 结合的靶核酸分子作为模板,并将反应混合物暴露于通过聚合酶可以合成核酸的温度。 此外,本发明涉及该方法的用途,例如用于产生mRNA或其他克隆文库以及用于进行该方法的试剂盒。

    Method and apparatus for structuring and searching biological, physical or chemical data
    39.
    发明公开
    Method and apparatus for structuring and searching biological, physical or chemical data 审中-公开
    对于构图和用于搜索生物,物理或化学数据的方法和装置

    公开(公告)号:EP1246076A1

    公开(公告)日:2002-10-02

    申请号:EP01107523.1

    申请日:2001-03-26

    IPC分类号: G06F17/30 G06F19/00

    CPC分类号: G06F19/24 G06F19/22

    摘要: The invention provides a method of structuring a set of signals representing biological, chemical and/or physical data, especially data related to the structure of biomolecules, according to predetermined patterns by means of an apparatus for processing said signals, especially patterns forming a hierarchy, wherein a pattern of a higher order comprises at least one pattern of a lower order, said method comprising the steps of:

    providing a set of signals,
    comparing a group of signals forming part of said set to one or more predetermined patterns by means of said processing apparatus,
    if a match is found, modifying said set of signals by said processing apparatus, said step of modifying said set comprising the step of replacing the group of signals matching the pattern by a unit of signals, said unit having an order corresponding to the order of the matching pattern and comprising information on the signals comprised in said unit.

    摘要翻译: 本发明提供了结构化的一组表示生物,化学和/或物理数据,爱特别是有关生物分子的结构数据,雅丁为预定图案由装置的方式处理所述信号,爱尤其图案形成层次结构的信号的方法, worin更高阶的模式包括低次序中的至少一个图案,所述方法包括以下步骤:提供一组信号,进行比较的一组形成所述的部分的信号设置为一或多个预定借助于所述图案 处理装置中,如果发现匹配,修改所述设置的由所述处理装置的信号,所述修改所述一组包括通过的信号的单元替换的图案匹配的组信号的步骤的步骤中,具有顺序对应于所述单元 匹配模式和对所述单元包括的信号包括信息的顺序。

    PROCESS AND APPARATUS FOR IN SILICO TWO-HYBRID ANALYSIS
    40.
    发明公开
    PROCESS AND APPARATUS FOR IN SILICO TWO-HYBRID ANALYSIS 审中-公开
    用于计算机芯片的方法和装置“双杂交”分析

    公开(公告)号:EP1224602A1

    公开(公告)日:2002-07-24

    申请号:EP00967780.8

    申请日:2000-09-26

    IPC分类号: G06F19/00

    CPC分类号: G06F19/22 G06F19/18

    摘要: Process for the determination of interacting biomolecules wherein a) a first group is provided comprising sequences representing homologous biomolecules, b) at least one second group is provided comprising sequences representing homologous biomolecules, c) group correlation values between the sequences of the first group and the sequences of at least one second group are determined, and d) the probability of the interaction of the sequence represented biomolecules is determined on the basis of the group correlation values.