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    MULTI-POLE ION TRAP FOR MASS SPECTROMETRY
    31.
    发明公开
    MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 审中-公开
    多极离子陷阱MASS

    公开(公告)号：EP2962094A2

    公开(公告)日：2016-01-06

    申请号：EP14756573.3

    申请日：2014-02-25

    申请人： The Rockefeller University

    发明人： KRUTCHINSKY, Andrew, N. ,  SHERMAN, Vadim ,  COHEN, Herbert ,  CHAIT, Brian, T.

    IPC分类号： G01N27/62 ,  G01N27/70 ,  G01T1/185 ,  H01J49/42

    CPC分类号： H01J49/06 ,  H01J49/02 ,  H01J49/36 ,  H01J49/4225 ,  H01J49/424

    摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.

    Human microRNAs and methods for inhibiting same
    37.
    发明公开
    Human microRNAs and methods for inhibiting same 审中-公开
    人类microRNA及其抑制方法

    公开(公告)号：EP2631293A2

    公开(公告)日：2013-08-28

    申请号：EP13168804.6

    申请日：2006-05-01

    申请人： THE ROCKEFELLER UNIVERSITY

    发明人： Tuschl, Thomas ,  Landgraf, Pablo

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2330/10

    摘要： The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467- 481 ; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell.

    摘要翻译： 本发明涉及分离的DNA或RNA分子，其包含在SEQ ID NO：1-94所示的微小RNA中具有序列的至少10个连续碱基; 281-374; 467-481; 497-522; 或549，除了高达百分之三十的碱基可以是摇摆碱基，并且多达10％的连续碱基可以是非互补的。 本发明进一步涉及修饰的单链微RNA分子，分离的单链抗微RNA分子和分离的微RNA分子。 在另一个实施方案中，本发明涉及用于抑制细胞中的微RNA活性的方法。

    Stimulation of pancreatic beta-cell proliferation
    38.
    发明公开
    Stimulation of pancreatic beta-cell proliferation 审中-公开
    Stimulierung der Proliferation pankreatischer Beta-Zellen

    公开(公告)号：EP2605013A1

    公开(公告)日：2013-06-19

    申请号：EP12191514.4

    申请日：2006-06-07

    申请人： THE ROCKEFELLER UNIVERSITY

    发明人： Stoffel, Markus ,  Akpinar, Pinar

    IPC分类号： G01N33/53 ,  C12P21/06 ,  C12N15/00 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07H21/04 ,  A61K38/16

    CPC分类号： C07K14/705 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

    摘要： This invention provides a polypeptide, TMEM27, and secreted forms thereof, nucleic acids and constructs encoding the same, and cells comprising the same. The TMEM27 protein is expressed in hormone positive cells at early stages of pancreas development and pancreatic beta-cells in the mature pancreas, whose expression promotes pancreatic beta-cell replication and increased islet mass. Applications of the protein in diagnostics and therapeutics are described.

    摘要翻译： 本发明提供了一种多肽TMEM27及其分泌形式，编码其的核酸和构建体以及包含该多肽的细胞。 在成熟胰腺胰腺发育早期胰腺β细胞的激素阳性细胞中表达TMEM27蛋白，其表达促进胰腺β-细胞复制和增加的胰岛质量。 描述了蛋白质在诊断和治疗中的应用。