公开(公告)号：EP1563071A2

公开(公告)日：2005-08-17

申请号：EP03786019.4

申请日：2003-11-18

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)

发明人： SEVE, Michel ,  FAVIER, Alain

IPC分类号： C12N15/12 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  A01K67/027 ,  C12N15/11

CPC分类号： G01N33/6872 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2500/10

摘要： The invention relates to protein ZnT-8 which is specifically expressed in the pancreatic beta cells in islets of Langerhans, to a polynucleotide encoding said protein which is involved in the maturation and exocytosis of insulin, and to the applications thereof, for example, for sorting and studying beta cells and for screening medicine acting on diabetes and hyperinsulinism.

公开(公告)号：EP1319063A1

公开(公告)日：2003-06-18

申请号：EP01972175.2

申请日：2001-09-20

申请人： Universite Joseph Fourier (Grenoble 1)

发明人： BLANQUET GROSSARD, Françoise ,  CESBRON, Jean-Yves ,  LEMAIRE VIEILLE, Catherine ,  FOLLET, Jérôme

IPC分类号： C12N5/06 ,  C12N1/04 ,  C12P21/00 ,  C12Q1/02

CPC分类号： G01N33/6896 ,  C07K14/47 ,  C12N5/0622 ,  G01N2800/2828

摘要： The invention concerns a method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies, or prion, comprising steps which consist in: providing a culture or a glial cell line and in infecting the culture or line with the agent responsible for transmissible spongiform encephalopathies or prion. Said method enables to obtain infected cell lines capable of being used to assess the efficacy of a molecule in the reduction or inhibition of the infectiosity of the prion or for detecting the prion.

公开(公告)号：EP1163516A1

公开(公告)日：2001-12-19

申请号：EP00910959.6

申请日：2000-03-16

申请人： UNIVERSITE JOSEPH FOURIER - Grenoble 1

发明人： DROUET, Emmanuel ,  VERNIOL, Cécile ,  DROUET, Christian

IPC分类号： G01N33/50 ,  C07K14/05 ,  A61K38/00 ,  A61K39/245 ,  A61K9/00 ,  A61K31/365

CPC分类号： G01N33/5047 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  C07K14/005 ,  C12N2710/16222 ,  C12N2710/16234

摘要： The invention concerns a method for screening immunogenic peptides using Brefeldin A to enhance the effect of presentation of said peptides by antigen-presenting cells. The invention also concerns immunogenic peptides obtainable by said method, in particular peptide P100, and the use of a peptide P100 compound for preparing a medicine designed to treat and/or prevent EBV-induced diseases, in particular for treating and/or preventing Burkitt lymphoma, nasopharyngeal carcinoma, and/or Hodgkin's disease.

公开(公告)号：EP0468841B1

公开(公告)日：1994-06-15

申请号：EP91401864.3

申请日：1991-07-05

申请人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)

发明人： Günther, Roland ,  Terriez, Jean-Michel

IPC分类号： B65G17/02 ,  B65G15/60

CPC分类号： B65G17/02 ,  B65G2201/04

公开(公告)号：EP2848695A1

公开(公告)日：2015-03-18

申请号：EP13306266.1

申请日：2013-09-16

申请人： INRIA - Institut National de Recherche en Informatique et en Automatique ,  Universite Joseph Fourier - Grenoble 1

发明人： Geiselmann, Johannes ,  De Jong, Hidde ,  Ropers, Delphine ,  Izard, Jerôme

IPC分类号： C12P21/02 ,  C12N9/12 ,  C12N15/72

CPC分类号： C12P21/00 ,  C12N9/1247 ,  C12N15/70 ,  C12N15/72 ,  C12P7/20 ,  C12P21/02 ,  C12Y207/07006

摘要： The present invention relates to a method for producing a molecule of interest in bacteria which is based on a reversible growth arrest of the bacteria at the cellular growth global control system level, thus allowing an improved yield of production of said molecule of interest.

摘要翻译： 本发明涉及一种在细菌中产生感兴趣的分子的方法，其基于在细胞生长全局控制系统水平上细菌的可逆生长停滞，从而允许提高所述目的分子的产量。

公开(公告)号：EP2477554B1

公开(公告)日：2013-08-28

申请号：EP10752838.2

申请日：2010-09-16

申请人： Universite Joseph Fourier - Grenoble 1 ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Centre Hospitalier Universitaire Grenoble

发明人： MONTESSUY, Renaud ,  RATEL, David ,  GAY, Emmanuel ,  PASSAGIA, Jean-Guy ,  BERGER, François ,  ISSARTEL, Jean-Paul

IPC分类号： A61B10/02 ,  A61B17/00 ,  A61B17/34 ,  A61B19/00

CPC分类号： A61B10/02 ,  A61B2017/00738 ,  A61B2017/3419 ,  A61B2017/3456 ,  A61B2090/036

公开(公告)号：EP2615181A1

公开(公告)日：2013-07-17

申请号：EP12305031.2

申请日：2012-01-10

申请人： Universite Joseph Fourier - Grenoble 1 ,  Centre Hospitalier Universitaire Grenoble ,  Centre National de la Recherche Scientifique (C.N.R.S.) ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： Callanan Mary ,  Emadali, Anouk ,  Ferro, Myriam ,  Khochbin, Saadi ,  Pison-Rousseaux, Sophie

IPC分类号： C12Q1/68 ,  A61K39/00

CPC分类号： G01N33/57496 ,  A61K31/713 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2887 ,  C07K2317/73 ,  C07K2317/734 ,  C07K2317/75 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/4715 ,  A61K2300/00

摘要： The present invention concerns a method for the identification of the presence or absence of cancer cells in a biological sample, more particularly a method for the identification of the susceptibility or resistance to a treatment with CD20 agonists of cancer cells in a biological sample, said methods comprising determining the level of expression of the gene Cyclon in said cells and comparing said level of expression to the level of expression in a non-cancer cell, wherein a level of expression higher than the level of expression in a non-cancer cell is an indication of the presence of a cancer cell, more particularly an indication of cancer cells with a resistance to treatment with antagonists.
The invention also concerns kits for the determination of a level of expression of the Cyclon gene in a biological sample, a method for the identification of Cyclon expression antagonists, as well as methods for treating patients in need thereof with CD20 agonists when the patients are identified to be susceptible to such a treatment and/or treating patients in need thereof with a combination of a Cyclon inhibitor and a CD20 agonists.

摘要翻译： 本发明涉及用于鉴定生物样品中癌细胞存在或不存在的方法，更具体地，涉及用于鉴定生物样品中癌细胞的CD20激动剂的敏感性或耐药性的方法，所述方法 包括确定所述细胞中基因Cyclon的表达水平，并将所述表达水平与非癌细胞中的表达水平进行比较，其中高于非癌细胞中的表达水平的表达水平为 指示癌细胞的存在，更具体地说是具有抗拮抗剂治疗耐药性的癌细胞的指征。 本发明还涉及用于测定生物样品中Cyclon基因表达水平的方法，用于鉴定Cyclon表达拮抗剂的方法，以及当鉴定患者时用CD20激动剂治疗有需要的患者的方法 易于进行这种治疗和/或治疗有需要的患者与Cyclon抑制剂和CD20激动剂的组合。

公开(公告)号：EP2604682A1

公开(公告)日：2013-06-19

申请号：EP11306636.9

申请日：2011-12-12

申请人： Universite Joseph Fourier - Grenoble 1 ,  Centre Hospitalier Universitaire de Grenoble

发明人： Le Gouellec, Audrey ,  Toussaint, Bertrand ,  Polack, Benoît

IPC分类号： C12N1/20 ,  C12R1/38 ,  A61K39/00

CPC分类号： C12N1/36 ,  A61K39/0005 ,  A61K39/0011 ,  A61K2039/522 ,  A61K2039/523 ,  C07K14/435 ,  C12N1/20 ,  C12N15/102 ,  C12N15/78 ,  C12R1/38

摘要： The invention is related to a process for obtaining an adapted strain of Pseudomonas, comprising the following steps:
• deleting the genes ExoS ExoT, aroA and lasI in an initial Pseudomonas strain cultivated in a LB medium,
• progressively cultivating this strain in a chemically defined medium based on a glucose minimal medium supplemented with magnesium and calcium,

wherein the adapted strain presents the same toxicity and secretion capacities than the initial strain, and its doubling time when cultivated in said chemically defined medium is less than 60 minutes.
The present invention is also related to the adapted strain such as obtained,in particular wherein the adapted strain is furthermore treated to become 'killed but metabolically active'.

摘要翻译： 本发明涉及一种方法，用于获得假单胞菌的angepasst应变的方法，包括以下步骤：在LB培养基中培养初始假单胞菌菌株在€¢删除基因EXOS ExoT，的aroA和椰子，€¢在逐步培养该菌株 化学成分确定的培养基基于补充有镁和钙，所述worin应变angepasst呈现比初始菌株相同的毒性和分泌能力葡萄糖基本培养基上，并确定了其倍增时间当所述化学培养介质是少于60分钟。 因此，本发明是有关angepasst应变：如获得特别worin的angepasst菌株更进一步处理以变成“杀死但具有代谢活性”。

公开(公告)号：EP2210255B1

公开(公告)日：2013-01-02

申请号：EP08871186.6

申请日：2008-11-07

申请人： Centre National de la Recherche Scientifique ,  Universite Joseph Fourier (Grenoble 1) ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： GAUDIN, Gilles, Louis ,  ZERMATTEN, Pierre-Jean ,  MIRON, Ioan, Mihai ,  SCHUHL, Alain

IPC分类号： G11B5/855

CPC分类号： G11B5/855 ,  G11B5/66

公开(公告)号：EP2477554A1

公开(公告)日：2012-07-25

申请号：EP10752838.2

申请日：2010-09-16

申请人： Universite Joseph Fourier - Grenoble 1 ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  Centre Hospitalier Universitaire Grenoble

发明人： MONTESSUY, Renaud ,  RATEL, David ,  GAY, Emmanuel ,  PASSAGIA, Jean-Guy ,  BERGER, François ,  ISSARTEL, Jean-Paul

IPC分类号： A61B10/02 ,  A61B17/00 ,  A61B17/34 ,  A61B19/00

CPC分类号： A61B10/02 ,  A61B2017/00738 ,  A61B2017/3419 ,  A61B2017/3456 ,  A61B2090/036

摘要： The present invention relates to a surgical instrument (1) for sampling molecules from an organ to which access is possible directly or via a surgical approach, including: a device (5) for capturing said molecules, a stylus (4) supporting said capture device (5) and which is capable of penetrating the organ, and a guide (3) for inserting the stylus (4) into the body up to the organ, characterized in that the distal end of the guide (3) is provided with a damping block (6) intended to bear against the organ.