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公开(公告)号：EP3329920A3
公开(公告)日：2019-01-09
申请号：EP17208289.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
摘要： Die Erfindung betrifft Adrenorezeptor α2C Rezeptor Antagonisten zur Verwendung in einem Verfahren zur Behandlung und/oder Prophylaxe von Begleit- und/oder Folgeerkrankungen von Diabetes mellitus, diabetischen Herzerkrankungen, diabetischen koronaren Herzerkrankungen, diabetischen koronaren mikrovaskulären Herzerkrankungen, diabetischer Herzinsuffizienz, diabetischer Kardiomyopathie und Herzinfarkt, diabetischer Mikroangiopathie, diabetischer Retinopathie, diabetischer Neuropathie, diabetischer Nephropathie, diabetischer erektiler Dysfunktion, diabetischen Geschwüren an den Extremitäten, diabetischen Fußulzera, zur Förderung der diabetischen Wundheilung und zur Förderung der Wundheilung von diabetischen Fußulzera.
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32.发明公开AMINO-SUBSTITUIERTE IMIDAZO[1,2-A]PYRIDINCARBOXAMIDE UND IHRE VERWENDUNG 有权氨基取代的咪唑并[1,2-A]吡啶甲酰胺及其用途
公开(公告)号：EP2914594A1
公开(公告)日：2015-09-09
申请号：EP13785869.2
申请日：2013-11-04
发明人： VAKALOPOULOS, Alexandros , FOLLMANN, Markus , HARTUNG, Ingo , BUCHGRABER, Philipp , JAUTELAT, Rolf , HAßFELD, Jorma , LINDNER, Niels , GROMOV, Alexey , WUNDER, Frank , STASCH, Johannes-Peter , REDLICH, Gorden , LI, Volkhart Min-Jian , BECKER-PELSTER, Eva Maria , KNORR, Andreas
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The invention relates to novel substituted imidazo[1,2-a]pyridino-3-carboxamides, to methods for their production, their use alone or in combination for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.
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公开(公告)号：EP2142504B1
公开(公告)日：2011-10-26
申请号：EP08716565.0
申请日：2008-03-15
发明人： HAHN, Michael , BECKER, Eva-Maria , KNORR, Andreas , SCHNEIDER, Dirk , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , LANG, Dieter
IPC分类号： C07D211/76 , C07D239/10 , C07D263/22 , C07D265/32 , C07D207/267
CPC分类号： C07D207/267 , C07D211/76 , C07D239/10 , C07D263/22 , C07D265/32
摘要： The invention relates to novel lactam-substituted dicarboxylic acid derivatives, to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
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34.发明授权
公开(公告)号：EP3083592B1
公开(公告)日：2018-06-27
申请号：EP14812245.0
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
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公开(公告)号：EP3329920A2
公开(公告)日：2018-06-06
申请号：EP17208289.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , A61K31/541 , A61P7/00 , A61P9/00 , A61P17/02
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D417/14 , C07D491/107
摘要： Die Erfindung betrifft Adrenorezeptor α2C Rezeptor Antagonisten zur Verwendung in einem Verfahren zur Behandlung und/oder Prophylaxe von Begleit- und/oder Folgeerkrankungen von Diabetes mellitus, diabetischen Herzerkrankungen, diabetischen koronaren Herzerkrankungen, diabetischen koronaren mikrovaskulären Herzerkrankungen, diabetischer Herzinsuffizienz, diabetischer Kardiomyopathie und Herzinfarkt, diabetischer Mikroangiopathie, diabetischer Retinopathie, diabetischer Neuropathie, diabetischer Nephropathie, diabetischer erektiler Dysfunktion, diabetischen Geschwüren an den Extremitäten, diabetischen Fußulzera, zur Förderung der diabetischen Wundheilung und zur Förderung der Wundheilung von diabetischen Fußulzera.
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36.发明公开SUBSTITUIERTE BIPIPERIDINYL-DERIVATE ALS ADRENOREZEPTOR ALPHA 2C ANTAGONISTEN 审中-公开取代联哌啶衍生物作为支撑ALPHA 2C受体拮抗剂
公开(公告)号：EP3083594A1
公开(公告)日：2016-10-26
申请号：EP14815662.3
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GNOTH, Mark Jean , HIMMEL, Herbert , KAST, Raimund , KLAR, Jürgen , KNORR, Andreas , LANG, Dieter , LINDNER, Niels , SCHMECK, Carsten , SCHOHE-LOOP, Rudolf , TINEL, Hanna , TRÜBEL, Hubert , WUNDER, Frank
IPC分类号： C07D401/14 , C07D211/16 , C07D211/22 , C07D211/42 , C07D401/12 , C07D403/04 , C07D413/04 , C07D413/10 , C07D413/12 , A61K31/4468 , A61K31/4523 , A61P3/10 , A61P9/00
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, especially for promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulation disorders, Raynaud phenomena, CREST syndrome, microcirculation disorders, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：EP2493845A1
公开(公告)日：2012-09-05
申请号：EP10768933.3
申请日：2010-10-21
发明人： LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER, Eva-Maria , STOLL, Friederike , KNORR, Andreas
IPC分类号： C07C233/55 , C07C255/60 , C07D305/06 , A61K31/277 , A61K31/167 , A61K31/337 , A61P9/00
CPC分类号： C07C233/88 , A61K31/196 , A61K31/655 , C07C205/38 , C07C231/02 , C07C233/45 , C07C233/55 , C07C255/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D305/06
摘要： The present invention relates to novel 3-phenylpropionic acid derivatives, to a method for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for producing medications for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
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公开(公告)号：EP2406215A1
公开(公告)日：2012-01-18
申请号：EP10706154.1
申请日：2010-02-24
发明人： LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , HEITMEIER, Stefan , GRIEBENOW, Nils , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER, Eva-Maria , STOLL, Friederike , KNORR, Andreas
IPC分类号： C07D209/46 , C07D237/14 , C07D273/04 , A61K31/4035 , A61K31/50 , A61K31/5395 , A61P9/00
CPC分类号： C07D273/04 , A61K31/4035 , A61K31/495 , A61K31/50 , A61K31/5395 , C07D209/46 , C07D237/14
摘要： The present application relates to novel alkyl carboxylic acids, having an oxo-substituted aza-heterocyclical partial structure, to a method for producing same, to the use thereof for treating and/or preventing disease, and to the use thereof for formulating pharmaceutical products for treating and/or preventing disease, in particular for treating and/or preventing cardiovascular conditions.
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39.发明授权
公开(公告)号：EP2029591B1
公开(公告)日：2011-09-07
申请号：EP07725745.9
申请日：2007-06-01
发明人： FIGUEROA PEREZ, Santiago , KOLKHOF, Peter , BÄRFACKER, Lars , FLAMME, Ingo , SCHLEMMER, Karl-Heinz , GROSSER, Rolf , MÜNTER, Klaus , KNORR, Andreas , NITSCHE, Adam
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/00
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, to processes for their preparation, to their use for treatment and/or prophylaxis of disorders and to their use for producing medicaments for treatment and/or prophylaxis of disorders, especially of cardiovascular disorders.
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40.发明授权N-[3-(2-CARBOXYETHYL)PHENYL]-PIPERIDIN-1-YLACETAMID- DERIVATE UND IHRE VERWENDUNG ALS AKTIVATOREN DER LÖSLICHEN GUANYLATCYCLASE 有权N- [3-（2-羧乙基）苯基] - 哌啶-1- YLACETAMID-衍生物和它们作为可溶性鸟苷酸环化酶活化剂使用
公开(公告)号：EP2852573B1
公开(公告)日：2017-02-01
申请号：EP13722773.2
申请日：2013-05-17
发明人： LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER-PELSTER, Eva Maria , STOLL, Friederike , KNORR, Andreas
IPC分类号： C07D211/06 , C07D211/14 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15 , A61K31/438 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/472 , A61P9/00
CPC分类号： C07D211/14 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/472 , A61K45/06 , C07D211/06 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15
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