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公开(公告)号：EP4162034A1
公开(公告)日：2023-04-12
申请号：EP21729331.5
申请日：2021-06-01
申请人： BioNTech SE , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： PERKOVIC, Mario , WITZEL, Sonja , BEISSERT, Tim , SAHIN, Ugur
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公开(公告)号：EP4126039A1
公开(公告)日：2023-02-08
申请号：EP21715268.5
申请日：2021-03-30
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33.发明公开
公开(公告)号：EP4119582A1
公开(公告)日：2023-01-18
申请号：EP22181929.5
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K39/00 , A61P35/00 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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34.发明公开
公开(公告)号：EP4082565A1
公开(公告)日：2022-11-02
申请号：EP22166898.1
申请日：2016-05-09
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana , BREITKREUZ, Andrea , MROZ, Karolina Anna , HEBICH, Lisa
IPC分类号： A61K39/00 , A61P35/00 , A61P37/04 , C07K7/06 , C07K14/725 , C07K16/28 , C07K14/705
摘要： The present invention provides Claudin-18.2-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and T cell epitopes which are useful for immunotherapy.
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公开(公告)号：EP3954383A1
公开(公告)日：2022-02-16
申请号：EP21191307.4
申请日：2016-02-09
申请人： BioNTech SE , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , LÖWER, Martin , TADMOR, Arbel D. , BOEGEL, Sebastian , SCHRÖRS, Barbara , VORMEHR, Mathias , KREITER, Sebastian
摘要： The present invention relates to methods for predicting T cell epitopes useful for vaccination. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic and, in particular, useful for vaccination, or for predicting which of such modifications are most immunogenic and, in particular, most useful for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and thus, in the context of personalized cancer vaccines.
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公开(公告)号：EP3881827A1
公开(公告)日：2021-09-22
申请号：EP21165536.0
申请日：2017-07-14
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
发明人： SAHIN, Ugur , HAAS, Heinrich , VOGEL, Annette , ZUCKER, Daniel , ERBAR, Stephanie , REUTER, Kerstin , SCHLEGEL, Anne , HÖRNER, Sebastian , KREITER, Sebastian , DIKEN, Mustafa , MORENO HERRERO, Jorge
摘要： The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.
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公开(公告)号：EP3679069A1
公开(公告)日：2020-07-15
申请号：EP18765858.8
申请日：2018-09-05
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K16/28
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公开(公告)号：EP2852409B1
公开(公告)日：2020-03-25
申请号：EP13729591.1
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06
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公开(公告)号：EP3600389A1
公开(公告)日：2020-02-05
申请号：EP18716138.5
申请日：2018-03-21
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： BIHI, Mahjoub , SAHIN, Ugur , DIKEN, Mustafa , KLAMP, Thorsten
IPC分类号： A61K39/00
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公开(公告)号：EP3594337A1
公开(公告)日：2020-01-15
申请号：EP19180818.7
申请日：2015-07-06
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
摘要： The present invention relates to nucleic acid molecules containing poly(dA:dT) regions which are stabilized in E.coli, methods of propagating such nucleic acid molecules in E.coli, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly(dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.
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