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公开(公告)号：EP2928881A1
公开(公告)日：2015-10-14
申请号：EP13799520.5
申请日：2013-12-02
发明人： FREI, Beat , GOBBI, Luca , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D401/14 , C07D413/14 , C07D213/81 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/44 , A61K31/4427 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00
CPC分类号： C07D213/81 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中R 1至R 3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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32.发明授权[1,2,3]TRIAZOLO[4,5-d]PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 AGONISTS 有权[1,2,3]三唑并[4,5-d]嘧啶衍生物作为大麻素受体2激动剂的激动剂
公开(公告)号：EP2782915B1
公开(公告)日：2015-09-30
申请号：EP12794684.6
申请日：2012-11-22
发明人： BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D487/04 , A61K31/519 , A61K9/00 , A61K47/10 , A61K47/12 , A61K9/48 , A61K9/20
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K47/10 , A61K47/12
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公开(公告)号：EP2686307A1
公开(公告)日：2014-01-22
申请号：EP12709616.2
申请日：2012-03-15
发明人： GABELLIERI, Emanuele , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander V. , ROGERS-EVANS, Mark , ROMBACH, Didier , THOMAS, Andrew , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , A61K31/553 , A61P25/28 , A61P3/10
CPC分类号： C07D267/10 , C07D413/12
摘要： The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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34.发明公开2-AMINO-5, 5-DIFLUORO-5, 6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS 审中-公开2-氨基-5,5-二氟-5,6-二氢-4H-恶嗪AS BACE 1和/或2 BACE抑制剂
公开(公告)号：EP2509965A1
公开(公告)日：2012-10-17
申请号：EP10785437.4
申请日：2010-12-06
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , PINARD, Emmanuel , POWER, Eoin , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D265/08 , C07D413/12 , A61K31/535 , A61K31/5355
CPC分类号： C07D265/08 , C07D413/12
摘要： The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)- phenyl]-amide derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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35.发明公开
公开(公告)号：EP2467368A1
公开(公告)日：2012-06-27
申请号：EP10742166.1
申请日：2010-08-16
发明人： ANDREINI, Matteo , BANNER, David , GUBA, Wolfgang , HILPERT, Hans , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , TRAVAGLI, Massimiliano , VALACCHI, Michela , WOLTERING, Thomas , WOSTL, Wolfgang , GABALLIERI, Emanuele
IPC分类号： C07D265/30 , C07D413/12 , A61K31/5377
CPC分类号： C07D413/12 , C07D265/30 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[l,4]oxazine derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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公开(公告)号：EP2102186B1
公开(公告)日：2011-10-05
申请号：EP07847500.1
申请日：2007-11-29
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D401/04 , C07D413/14 , A61K31/404 , A61P29/00
CPC分类号： C07D401/04 , C07D413/14
摘要： The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders 5 and other diseases. Present invention is concerned with compounds of the general formula (I), A: (a), (b), (c) wherein R1 to R6, R8 to R14, R12', R13', X and Y are as defined in the specification.
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公开(公告)号：EP2102186A1
公开(公告)日：2009-09-23
申请号：EP07847500.1
申请日：2007-11-29
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D401/04 , C07D413/14 , A61K31/404 , A61P29/00
CPC分类号： C07D401/04 , C07D413/14
摘要： The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders 5 and other diseases. Present invention is concerned with compounds of the general formula (I), A: (a), (b), (c) wherein R1 to R6, R8 to R14, R12', R13', X and Y are as defined in the specification.
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公开(公告)号：EP2089381A1
公开(公告)日：2009-08-19
申请号：EP07847501.9
申请日：2007-11-29
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D401/14 , C07D491/04 , A61K31/4427 , A61P25/22 , A61P25/24
CPC分类号： C07D401/14 , C07D491/04
摘要： The present invention is concerned with novel indol-2-yl-carbonyl-piperidin- benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. Present invention comprises compounds of the general formula (I) wherein R1 to R11, X and Y are as defined in the specification.
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39.发明公开
公开(公告)号：EP1931680A1
公开(公告)日：2008-06-18
申请号：EP06793584.1
申请日：2006-09-18
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D491/10 , C07D471/10 , A61K31/4355 , A61K31/437 , A61P9/00 , A61P25/00
CPC分类号： C07D471/10 , C07D491/10
摘要： This invention relates to indol-3-yl-carbonyl-azaspiro derivatives which act as Via receptor antagonists and which are represented by Formula (I) wherein the azaspiro-head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders, and methods of preparation thereof.
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公开(公告)号：EP1532132B1
公开(公告)日：2008-03-19
申请号：EP03766236.8
申请日：2003-07-18
发明人： ALANINE, Alexander , BLEICHER, Konrad , GUBA, Wolfgang , HAAP, Wolfgang , KUBER, Dagmar , LUEBBERS, Thomas , PLANCHER, Jean-Marc , ROGERS-EVANS, Mark , SCHNEIDER, Gisbert , ZUEGGE, Jochen , ROCHE, Olivier
IPC分类号： C07D317/62 , C07D405/12 , C07D317/54 , C07D451/06 , A61K31/36
CPC分类号： C07D317/46 , C07D317/72 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/06 , C07D451/06 , C07D491/10
摘要： The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
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