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31.发明公开
公开(公告)号：EP2773371A1
公开(公告)日：2014-09-10
申请号：EP12846339.5
申请日：2012-11-02
申请人： National University of Singapore , Institut National de la Santé et de la Recherche Médicale (INSERM) , Institut Pasteur de Lille
摘要： Described herein are compositions, vaccines, and methods that include use of a mutated Bordetella strain against allergic diseases such as asthma and skin inflammation. Also described are kits. Other compositions, vaccines, and methods are also described.
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32.发明公开LIVE ATTENUATED BORDETELLA STRAINS AS A SINGLE DOSE VACCINE AGAINST WHOOPING COUGH 有权活的减毒百日咳菌单次剂量百日咳疫苗
公开(公告)号：EP1994139A1
公开(公告)日：2008-11-26
申请号：EP07711815.6
申请日：2007-03-07
CPC分类号： A61K39/099 , A61K2039/522 , A61K2039/523 , A61K2039/543
摘要： A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
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33.发明授权
公开(公告)号：EP0918854B1
公开(公告)日：2004-10-27
申请号：EP97937621.7
申请日：1997-08-12
发明人： MAGDALENA, Juana , SUPPLY, Philip , LOCHT, Camille
CPC分类号： C12N15/11 , C07K14/35 , C12Q1/689 , Y10S435/81
摘要： The invention concerns a M. tuberculosis complex mycobacteria specific fragment of nucleic acids, comprising a nucleotide chain selected among the SEQ ID NO. 1 sequence, the SEQ ID N 2 sequence, their complementary sequences or the nucleic acid sequences capable of being hybridised with one of the preceding sequences in conditions of high stringency. The invention also concerns uses of said sequences for the detection and differential diagnosis of mycobacteria members of the M. tuberculosis complex, in particular the BCG differential diagnosis of other members of the complex.
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公开(公告)号：EP0941241A1
公开(公告)日：1999-09-15
申请号：EP97944948.0
申请日：1997-10-09
发明人： MIELCAREK, Nathalie , LOCHT, Camille , RIVEAU, Gilles , POULAIN-GODEFROY, Odile , CAPRON, André
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
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35.发明公开PROTEINES RECOMBINANTES DE L'HEMAGGLUTININE FILAMENTEUSE DE $i(BORDETELLA), NOTAMMENT $i(BORDETELLA PERTUSSIS), PROCEDE POUR LEUR PRODUCTION ET LEURS APPLICATIONS A LA PRODUCTION DE PROTEINES ETRANGERES OU DE PRINCIPES ACTIFS VACCINANTS 失效百日咳，尤其是百日咳百日咳，方法与VERWENDUNGZUR重组PROTEUINE丝状HAEMAGLUTININS产生杂质蛋白或疫苗
公开(公告)号：EP0755447A1
公开(公告)日：1997-01-29
申请号：EP95918030.0
申请日：1995-04-19
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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