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公开(公告)号：EP3587419A1
公开(公告)日：2020-01-01
申请号：EP18757942.0
申请日：2018-02-27
发明人： XU, Xiaofeng , WANG, Jiabing , DING, Lieming , LIU, Xiangyong
IPC分类号： C07D471/14 , C07D519/00 , A61K31/4985 , A61K31/437 , A61K31/4375 , A61P35/00
摘要： An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).
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公开(公告)号：EP3502105A1
公开(公告)日：2019-06-26
申请号：EP17855006.7
申请日：2017-09-29
发明人： LIANG, Congxin , XIE, Lihua
IPC分类号： C07D403/14 , A61K31/404 , A61P35/00
摘要： The invention discloses polymorphic forms of a compound of formula I, pharmaceutical compositions containing same, preparation method therefor and use thereof. The compound of formula I of the present invention is as shown in formula I, of which the crystalline form can be crystalline form 1, crystalline form 2, crystalline form 3, crystalline form 5, crystalline form 6 or crystalline form 7. All the crystalline forms of the compound of formula I in the present invention have good crystalline stability and chemical stability and a decrease in purity of their main ingredient less than 2%. The preparation method of the present invention may be used to produce the various crystalline forms of the compound of formula I with high purity, and suitable for large scale production.
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33.发明公开CRYSTALLINE FORM OF FUSED PYRIDINE DERIVATIVE'S MALEATE AND USES THEREOF 审中-公开结晶形式的稠合吡啶衍生物的马来酸酯及其用途
公开(公告)号：EP3292115A1
公开(公告)日：2018-03-14
申请号：EP16827230.0
申请日：2016-07-20
发明人： HU, Shaojing , LONG, Wei , ZHOU, Liufeng , XU, Zhiguo , WANG, Fei
IPC分类号： C07D401/14 , C07D487/04 , A61K31/437 , A61P35/00
摘要： The compound of Formula I, the crystalline form thereof, and methods of preparing and using them are provided.
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34.发明公开ICOTINIB-CONTAINING TOPICAL SKIN PHARMACEUTICAL COMPOSITION AND USE THEREOF 审中-公开ICOTINIBHALTIGE PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR TOPISCHEN ANWENDUNG AUF DER HAUT UND VERWENDUNG DAVON
公开(公告)号：EP3056206A4
公开(公告)日：2017-07-05
申请号：EP14851908
申请日：2014-10-11
发明人： WANG YINXIANG , YUAN SHUJUN , WANG YANPING , HU SHAOJING , HU YUNYAN
IPC分类号： A61K31/519 , A61K9/00 , A61K9/06 , A61P17/00 , A61P35/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/06
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35.发明公开POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF 有权化合物的多晶形式PROLYLHYDROXYLASEHEMMER及其用途
公开(公告)号：EP2734504A1
公开(公告)日：2014-05-28
申请号：EP12817360.6
申请日：2012-07-23
发明人： KANG, Xinshan , LONG, Wei , ZHANG, Jianxi , HU, Yunyan , WANG, Yinxiang
IPC分类号： C07D217/26 , A61K31/472 , A61P3/10 , A61P7/06 , A61P9/12 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00
CPC分类号： C07D217/26 , A61K31/472 , C07B2200/13
摘要： The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.
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36.发明公开
公开(公告)号：EP4360634A1
公开(公告)日：2024-05-01
申请号：EP22827568.1
申请日：2022-06-21
发明人： GUO, Jing , YAN, Dan , WANG, Yu , XU, Tong , LI, Kao , XU, Wei , LAN, Hong , DING, Lieming , WANG, Jiabing
IPC分类号： A61K31/4985 , A61P35/00
CPC分类号： A61K31/4985 , A61P35/00
摘要： The present invention provides an application of a compound in the preparation of drug for treating myelofibrosis and the related symptoms/signs thereof, and a use of the compound. The compound is selected form one or more of a compound having a structure as shown in formula I, and a pharmaceutically-acceptable salt, prodrug, solvate and hydrate thereof.
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公开(公告)号：EP3292115B1
公开(公告)日：2019-12-25
申请号：EP16827230.0
申请日：2016-07-20
发明人： HU, Shaojing , LONG, Wei , ZHOU, Liufeng , XU, Zhiguo , WANG, Fei
IPC分类号： C07D401/14 , C07D487/04 , A61K31/437 , A61P35/00 , C07D471/04
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公开(公告)号：EP3008071B1
公开(公告)日：2018-02-28
申请号：EP14811568.6
申请日：2014-06-09
发明人： HU, Shaojing , LONG, Wei , WANG, Fei , WANG, Yinxiang , DING, Lieming
IPC分类号： C07D491/056 , A61K31/519 , A61P35/00
CPC分类号： C07D491/056 , A61K9/20 , A61K9/48 , A61K31/519 , A61K45/06
摘要： The present invention relates to the polymorphic forms of the compound of Formula I, preparation thereof and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.
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公开(公告)号：EP3008070B1
公开(公告)日：2017-11-15
申请号：EP14811414.3
申请日：2014-06-09
发明人： HU, Shaojing , LONG, Wei , WANG, Fei , WANG, Yinxiang , DING, Lieming
IPC分类号： C07D491/056 , A61K31/519 , A61P35/00
CPC分类号： C07D491/056 , A61K31/517 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C57/145 , A61K2300/00
摘要： Provided are Icotinib maleate (the compound of Formula I) and polymorph forms thereof, and methods of preparing and using them.
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公开(公告)号：EP3007700B1
公开(公告)日：2017-06-28
申请号：EP14810815.2
申请日：2014-06-09
发明人： HU, Shaojing , LONG, Wei , WANG, Fei , WANG, Yinxiang , DING, Lieming
IPC分类号： A61K31/519 , C07D491/056 , A61P35/00
CPC分类号： C07D491/056 , A61K31/519 , A61K45/06 , C07B2200/13 , C30B7/00 , C30B7/14 , C30B29/54
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