公开(公告)号：EP2158224A4

公开(公告)日：2012-02-01

申请号：EP08772801

申请日：2008-06-12

申请人： UNIV ALBERTA

发明人： VASANTHAN THAVARATNAM ,  TEMELLI FERAL ,  GHOTRA BALJIT ,  KHAN MOHAMED

IPC分类号： C08B37/00 ,  C12P19/04 ,  C12P19/14 ,  C12S3/02

CPC分类号： C08B37/0003 ,  C08B37/0024 ,  C08L3/02 ,  C08L5/04 ,  C12P19/04 ,  C12P19/14

公开(公告)号：EP1718770A4

公开(公告)日：2008-04-02

申请号：EP05767641

申请日：2005-02-19

申请人： UNIV ALBERTA

发明人： MOORE STEPHEN STEWART

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention relates to single nucleotide polymorphisms (SNPs) in the leptin promoter, and to methods for the identification of animals carrying specific alleles of these SNPs that are associated with circulating leptin levels, feed intake, growth rate, body weight, carcass merit and carcass composition. The present invention provides oligonucleotides that can be used as primers and/or probes to amplify and/or detect these SNPs, and provides methods for selecting and grouping animals, in particular bovines, according to genotype.

公开(公告)号：EP1509087A4

公开(公告)日：2005-12-21

申请号：EP03755510

申请日：2003-05-27

申请人： WARATAH PHARMACEUTICALS INC ,  UNIV ALBERTA ,  BRAND STEPHEN J

发明人： BRAND STEPHEN J ,  RABINOVITCH ALEX ,  SUAREZ-PINZON WILMA LUCIA ,  CRUZ ANTONIO

IPC分类号： C12Q1/02 ,  A61K35/12 ,  A61K38/22 ,  A61L27/00 ,  C12N5/02 ,  C12N5/071 ,  G01N33/50 ,  A01N63/00 ,  A01N65/00 ,  C12N5/00 ,  C12N5/08

CPC分类号： A01K67/0271 ,  A01K2267/0362 ,  A61K35/12 ,  A61K38/2207 ,  C12N5/0676 ,  C12N2501/11 ,  C12N2501/148 ,  C12N2501/345 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/507 ,  G01N33/5073 ,  G01N33/5088 ,  A61K2300/00

摘要： Proliferating pancreatic islet cells obtained by the method of isolating a population of cells that preferably includes predominantly islet precursor cells that express one or more marker associated with an islet precursor cell and providing the precursor cells with one or more a pancreatic differentiation agent so that a population of cells is obtained that has a high proportion of cells with phenotypic characteristics of functional pancreatic islet beta-cells. Optionally, the precursor cells are pretreated by providing them with one or more cell expansion agent to increase the number of cells in the population prior to differentiation. The pancreatic differentiation agent composition comprises a gastrin/CCK receptor ligand, e.g., a gastrin, in an amount sufficient to effect differentiation of pancreatic islet precursor cells to mature insulin-secreting cells. The cell expansion agent composition comprises one or more epidermal growth factor (EGF) receptor ligand in an amount sufficient to stimulate proliferation of the precursor cells. The methods of treatment include transplanting either undifferentiated precursor cells and providing the pancreatic differentiation agent either alone or in combination with the cell expansion agent in situ, or transplanting the functional pancreatic islet beta-cells into the patient. The pancreatic islet beta-cells can be used for drug screening, and replenishing pancreatic function in the context of clinical treatment.

公开(公告)号：EP3027313A4

公开(公告)日：2017-04-12

申请号：EP14831181

申请日：2014-08-04

申请人： UNIV ALBERTA

发明人： BERGENS STEVEN H ,  KALAPUGAMA SUNETH ,  MCGINITIE ELIZABETH ,  NEPAL PRABIN

IPC分类号： B01J35/02 ,  B01J27/053 ,  B01J31/16 ,  B01J31/22 ,  B01J31/24 ,  B01J37/02

CPC分类号： B01J31/2452 ,  B01J19/24 ,  B01J27/053 ,  B01J31/165 ,  B01J31/2295 ,  B01J31/2409 ,  B01J35/02 ,  B01J37/0203 ,  B01J37/0209 ,  B01J2219/24 ,  B01J2231/52 ,  B01J2231/645 ,  B01J2531/0213 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  C07B35/02 ,  C07C29/56 ,  C07C45/00 ,  C07C51/36 ,  C07C67/303 ,  C07C231/12 ,  C07F15/0073

公开(公告)号：EP3022340A4

公开(公告)日：2017-02-22

申请号：EP14825858

申请日：2014-07-18

申请人： UNIV ALBERTA

发明人： DERDA RATMIR ,  DEISS FREDERIQUE

IPC分类号： B01J19/00 ,  C07K1/04 ,  C40B30/00 ,  C40B40/10 ,  C40B50/14 ,  G01N33/50

CPC分类号： B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00619 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00725 ,  C07K1/047 ,  G01N33/5005

摘要： The present application is directed to a porous support for parallel organic synthesis comprising: a solvophilic area for spotting an organic solvent comprising a reagent for synthesizing an organic compound, and a solvophobic area that repels the organic solvent. Methods of synthesizing the support and compounds thereon are also provided.

摘要翻译： 本申请涉及用于并行有机合成包含多孔载体：对于包括用于有机化合物的合成试剂的有机溶剂看上一个亲溶剂性区域和疏溶区域没有排斥的有机溶剂。 因此，提供在其上的支撑和化合物合成的方法。

公开(公告)号：EP2991675A4

公开(公告)日：2016-11-02

申请号：EP14778134

申请日：2014-04-04

申请人： UNIV ALBERTA

发明人： SZYMANSKI CHRISTINE ,  NOTHAFT HARALD

IPC分类号： A61K39/106 ,  A61P31/04 ,  A61P37/04 ,  C12N1/21

CPC分类号： A61K39/0208 ,  A23K10/18 ,  A23L33/135 ,  A23V2002/00 ,  A61K2039/106 ,  A61K2039/52 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/58 ,  C12P19/26

摘要： The present application provides a vaccine composition comprising: bacteria engineered to express at least one N-glycan of Campylobacter, such as C. jejuni for example, or an N-glycan derivative thereof on its cell surface; and one or more of a physiologically acceptable diluent, excipient, adjuvant or carrier. The bacteria is Escherichia coli, Salmonella or any suitable bacteria that offers sufficient expression and improved immunogenic response. The vaccine composition can be formulated for administration to animals, such as poultry, including chickens.

公开(公告)号：EP2734299A4

公开(公告)日：2016-05-11

申请号：EP12815389

申请日：2012-07-18

申请人： UNIV ALBERTA

发明人： BERGENS STEVEN ,  JOHN JEREMY M

IPC分类号： B01J31/18 ,  B01J31/24 ,  C07B31/00

CPC分类号： C07F15/0053 ,  B01J31/1805 ,  B01J31/189 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/643 ,  B01J2531/0244 ,  B01J2531/0255 ,  B01J2531/0266 ,  B01J2531/821 ,  C07B31/00 ,  C07B2200/07 ,  C07C29/149 ,  C07C41/26 ,  C07C209/50 ,  C07C213/00 ,  C07C231/08 ,  C07C303/40 ,  C07D201/02 ,  C07D295/023 ,  C07D295/027 ,  C07F15/0046 ,  C07C233/18 ,  C07C311/04 ,  C07C215/16 ,  C07C215/08 ,  C07C211/55 ,  C07C211/48 ,  C07C211/04 ,  C07C33/22 ,  C07C43/23 ,  C07C31/08

公开(公告)号：EP2707420A4

公开(公告)日：2014-10-29

申请号：EP12786289

申请日：2012-05-14

申请人： UNIV ALBERTA

发明人： BRESSLER DAVID CURTIS ,  CHOI PHILLIP

IPC分类号： C08H1/00 ,  C08J3/24 ,  C08J11/10 ,  C08L89/00 ,  C09J161/00 ,  C09J163/00 ,  C09J189/00

CPC分类号： C07K1/12 ,  C08G12/46 ,  C08H1/00 ,  C08J3/24 ,  C08J2389/00 ,  C08L63/00 ,  C08L89/00 ,  C09J189/00 ,  C08L21/00

公开(公告)号：EP2699257A4

公开(公告)日：2014-10-15

申请号：EP12774846

申请日：2012-04-20

申请人： UNIV LOUISIANA STATE ,  UNIV ALBERTA

发明人： CUTLER JIM E ,  XIN HONG ,  BUNDLE DAVID R ,  DZIADEK SEBASTIAN

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P31/10 ,  C07K14/00 ,  C07K16/14

CPC分类号： C07K16/14 ,  A61K39/0002 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/5158 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/6037 ,  C07K14/40 ,  C07K16/40 ,  C07K2319/00

公开(公告)号：EP2482978A4

公开(公告)日：2014-09-17

申请号：EP10818213

申请日：2010-09-28

申请人： UNIV ALBERTA

发明人： BERGENS STEVEN H ,  SULLIVAN ANDREW DOUGLAS ,  HASS MICHAEL

IPC分类号： B01J31/12 ,  C07B53/00 ,  C07D307/28 ,  C07F9/572

CPC分类号： C07F15/008 ,  B01J31/1658 ,  B01J31/1666 ,  B01J31/2409 ,  B01J2231/324 ,  B01J2531/0216 ,  B01J2531/0266 ,  B01J2531/822 ,  C07B53/00 ,  C07D307/28 ,  C07D403/10 ,  C07F9/5728