公开(公告)号：EP2891489A4

公开(公告)日：2016-01-27

申请号：EP13832194

申请日：2013-08-29

Applicant: UNIV TOKYO ,  NIHON NOHYAKU CO LTD

Inventor： KITA KIYOSHI ,  SUWA AKIYUKI ,  ODA MASATSUGU ,  TANAKA KOJI

IPC: A61K31/166 ,  A61K31/415 ,  A61K31/44 ,  A61P33/00 ,  C07C235/60 ,  C07C317/32 ,  C07C323/62 ,  C07D213/61 ,  C07D213/64 ,  C07D213/643 ,  C07D213/74 ,  C07D231/12 ,  C07D231/16 ,  C07D231/18 ,  C07D231/20 ,  C07D401/04

CPC classification number: C07D401/04 ,  A61K31/166 ,  A61K31/415 ,  A61K31/44 ,  C07C233/69 ,  C07C235/46 ,  C07C235/60 ,  C07C317/32 ,  C07C323/42 ,  C07C323/62 ,  C07D213/56 ,  C07D213/61 ,  C07D213/643 ,  C07D213/74 ,  C07D231/12 ,  C07D231/16 ,  C07D231/18 ,  C07D231/20

Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient.

公开(公告)号：EP2968569A1

公开(公告)日：2016-01-20

申请号：EP14764450.4

申请日：2014-03-17

Applicant: Argenta Manufacturing Limited ,  Cleverly, Douglas Robert ,  Gill, David Anthony ,  Davies, Keryn ,  Agarwal, Priyanka ,  Win, Su ,  Devaraj, Gopinath

Inventor： CLEVERLY, Douglas Robert ,  GILL, David Anthony ,  DAVIES, Keryn ,  AGARWAL, Priyanka ,  WIN, Su ,  DEVARAJ, Gopinath

IPC: A61K47/00

CPC classification number: A61K9/0056 ,  A23K20/10 ,  A23K20/158 ,  A23K20/168 ,  A23K20/179 ,  A23K20/184 ,  A23K20/195 ,  A23K40/10 ,  A23K40/20 ,  A23K40/25 ,  A23K40/30 ,  A23K50/42 ,  A61K9/0058 ,  A61K9/145 ,  A61K9/146 ,  A61K9/148 ,  A61K9/5015 ,  A61K9/5089 ,  A61K31/138 ,  A61K31/166 ,  A61K31/35 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5415 ,  A61K31/573 ,  A61K31/7048

Abstract: The present invention relates to a chewable formulation for delivering a nutritional or pharmaceutically active agent to an animal target. The chewable formulation comprises a nutritional ingredient or an effective amount of a pharmaceutically active agent, and a plasticiser. The chewable formulation is formed by extrusion and the formulation contains substantially no unbound water, nor is any water added in the manufacturing process. The present invention also relates to a method of manufacturing a shelf stable chewable formulation which comprises mixing the nutritional or pharmaceutically active agent with a fat, lipid or fat and lipid to obtain a first composition, adding one or more plasticizers to the first mixture to obtain a second composition, extruding the second composition at a temperature sufficient to melt the fat and lipid, and allowing the extruded second composition to cool to room temperature thereby providing the chewable formulation.

Abstract translation: 本发明涉及用于将营养或药用活性剂递送至动物靶的咀嚼型制剂。 可咀嚼制剂包含营养成分或有效量的药物活性剂和增塑剂。 可咀嚼的制剂通过挤出形成，并且制剂基本上不含未结合的水，在制造过程中也不添加任何水。 本发明还涉及制备贮存稳定的咀嚼制剂的方法，其包括将营养或药物活性剂与脂肪，脂质或脂肪和脂质混合以获得第一组合物，向第一混合物中加入一种或多种增塑剂以获得 第二组合物，在足以熔化脂肪和脂质的温度下挤出第二组合物，并将挤出的第二组合物冷却至室温，由此提供可咀嚼的制剂。

公开(公告)号：EP2964026A1

公开(公告)日：2016-01-13

申请号：EP14759577.1

申请日：2014-02-27

Applicant: Lixte Biotechnology, Inc.

Inventor： KOVACH, John S.

IPC: A01N43/40 ,  A61K31/44 ,  C07C321/00

CPC classification number: A61K31/4406 ,  A61K31/166 ,  A61K31/167

Abstract: The present inventions provides a method of treating a subject suffering from traumatic brain injury comprising administering to the subject an effective amount of an HDAC inhibitor, structurally represented, thereby treating the subject suffering from traumatic brain injury.

公开(公告)号：EP2194976B1

公开(公告)日：2015-12-09

申请号：EP08782880.2

申请日：2008-08-04

Applicant: Biotron Limited

Inventor： EWART, Gary, Dinneen ,  LUSCOMBE, Carolyn, Anne ,  MILLER, Michelle

IPC: A61K31/155 ,  A61K31/167 ,  A61K31/18 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/415 ,  A61K31/435 ,  A61P31/14 ,  A61K31/7064 ,  A61K31/7068 ,  A61K45/06 ,  A61K31/7056 ,  A61K38/21

CPC classification number: C07C279/22 ,  A61K31/155 ,  A61K31/166 ,  A61K31/167 ,  A61K31/18 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/415 ,  A61K31/435 ,  A61K31/4418 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07C311/08 ,  C07D213/69 ,  C07D231/12 ,  C07D307/54 ,  C07D333/24 ,  A61K2300/00

Abstract: The present invention relates to novel compositions having anti-viral activity and in particular it relates to synergistic compositions active against Hepatitis C virus (HCV). The invention also relates to methods for retarding, reducing or otherwise inhibiting HCV growth and/or functional activity.

公开(公告)号：EP2943181A1

公开(公告)日：2015-11-18

申请号：EP14700114.3

申请日：2014-01-09

Applicant: Kalvista Pharmaceuticals Limited

Inventor： COOK, Gary Paul ,  GWOZDZ, Garry Thomas ,  LASLO, Theodore Patrick

IPC: A61K9/00 ,  A61K9/10 ,  A61K31/00 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K31/165 ,  A61K9/0019 ,  A61K9/0051 ,  A61K9/10 ,  A61K9/14 ,  A61K31/00 ,  A61K31/166 ,  A61K31/18 ,  A61K31/198 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4436 ,  A61K31/445 ,  A61K31/455 ,  A61K45/06 ,  A61K47/183 ,  A61K47/26

Abstract: The invention relates to aqueous suspension pharmaceutical compositions of poorly water soluble drugs, wherein said drugs are selected from compounds of formula (I) (Formula (I)), wherein R1-R9 are defined herein; processes for preparing these compositions and their use in medicine, especially their use in the treatment of ocular diseases.

公开(公告)号：EP2903649A1

公开(公告)日：2015-08-12

申请号：EP13788684.2

申请日：2013-10-08

Applicant: Westfälische Wilhelms-Universität Münster ,  Pleschka, Stephan ,  Planz, Oliver

Inventor： PLESCHKA, Stephan ,  PLANZ, Oliver ,  LUDWIG, Stephan

IPC: A61K45/06 ,  A61K31/215 ,  A61K31/325 ,  A61K31/437 ,  A61K31/4458 ,  A61K31/52 ,  A61P31/14 ,  A61P31/16

CPC classification number: A61K31/519 ,  A61K31/166 ,  A61K31/18 ,  A61K31/185 ,  A61K31/215 ,  A61K31/245 ,  A61K31/325 ,  A61K31/353 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4458 ,  A61K31/506 ,  A61K31/52 ,  A61K31/535 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to MEK inhibitors that are capable of displaying one or more beneficial therapeutic effects. The MEK inhibitors can be used in the prevention and/or treatment of viral infection. MEK inhibitors in combination with neuraminidase inhibitor compounds are capable of displaying one or more beneficial therapeutic effects in the treatment of viral diseases.

公开(公告)号：EP2891489A1

公开(公告)日：2015-07-08

申请号：EP13832194.8

申请日：2013-08-29

Applicant: The University of Tokyo ,  Nihon Nohyaku Co., Ltd.

Inventor： KITA, Kiyoshi ,  SUWA, Akiyuki ,  ODA, Masatsugu ,  TANAKA, Koji

IPC: A61K31/166 ,  A61K31/415 ,  A61K31/44 ,  A61P33/00

CPC classification number: C07D401/04 ,  A61K31/166 ,  A61K31/415 ,  A61K31/44 ,  C07C233/69 ,  C07C235/46 ,  C07C235/60 ,  C07C317/32 ,  C07C323/42 ,  C07C323/62 ,  C07D213/56 ,  C07D213/61 ,  C07D213/643 ,  C07D213/74 ,  C07D231/12 ,  C07D231/16 ,  C07D231/18 ,  C07D231/20

Abstract: An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I):

or
a salt thereof as an active ingredient.

Abstract translation: 本发明的一个目的是提供一种新的内寄生虫防治剂作为杀寄生虫剂，抗原生动物剂等。 提供了一种内寄生物防治剂，其包含由通式（I）表示的甲酰胺衍生物或其盐作为活性成分。

公开(公告)号：EP2861254A2

公开(公告)日：2015-04-22

申请号：EP13732817.5

申请日：2013-06-13

Applicant: Acesion Pharma ApS

Inventor： GRUNNET, Morten ,  SØRENSEN, Ulrik Svane ,  BENTZEN, Bo Hjorth ,  DINESS, Jonas Goldin

IPC: A61K45/06 ,  A61K31/166 ,  A61K31/495

CPC classification number: A61K31/444 ,  A61K31/166 ,  A61K31/4458 ,  A61K31/495 ,  A61K2300/00

Abstract: This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective amount of a sodium channel inhibitor, in a combination with a small-conductance calcium-activated potassium (SK) channel inhibitor, for the treatment of cardiac arrhythmias.

Abstract translation: 本发明涉及包含治疗有效量的钠通道抑制剂与小传导性钙激活钾（SK）通道抑制剂组合用于治疗心律失常的药物组合物的用途。

公开(公告)号：EP2841409A1

公开(公告)日：2015-03-04

申请号：EP13719143.3

申请日：2013-04-24

Applicant: The University of Sussex

Inventor： MOORE, Anthony Lennox ,  ALBURY, Mary Susan ,  YOUNG, Luke Edward ,  ELLIOTT, Catherine

IPC: C07C39/24 ,  A01N35/04 ,  A61K31/11 ,  C07C69/63 ,  C07C39/373 ,  C07C43/178 ,  C07C47/565 ,  C07C49/835 ,  A61P31/04 ,  A61P31/10 ,  C07C255/53 ,  C07C235/60 ,  A01N49/00

CPC classification number: C07C255/53 ,  A01N31/16 ,  A01N35/04 ,  A01N37/02 ,  A01N37/24 ,  A01N37/34 ,  A01N37/40 ,  A01N37/44 ,  A01N49/00 ,  A01N63/04 ,  A61K31/055 ,  A61K31/085 ,  A61K31/11 ,  A61K31/12 ,  A61K31/166 ,  A61K31/222 ,  A61K31/277 ,  C07C39/245 ,  C07C39/373 ,  C07C43/1787 ,  C07C43/23 ,  C07C47/565 ,  C07C49/835 ,  C07C65/28 ,  C07C69/157 ,  C07C69/18 ,  C07C69/21 ,  C07C69/63 ,  C07C69/84 ,  C07C235/60 ,  Y02A50/409

Abstract: The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.

公开(公告)号：EP2827874A1

公开(公告)日：2015-01-28

申请号：EP13710411.3

申请日：2013-03-19

Applicant: Boehringer Ingelheim International GmbH

Inventor： MAYOUX, Eric Williams ,  GREMPLER, Rolf ,  KLEIN, Thomas

IPC: A61K31/70 ,  A61K31/135 ,  A61K31/365

CPC classification number: A61K31/166 ,  A61K9/2018 ,  A61K31/135 ,  A61K31/18 ,  A61K31/351 ,  A61K31/365 ,  A61K31/7034 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to the treatment of metabolic disorders in an overweight or obese patient characterized in that empagliflozin and one or more antiobesity drugs are administered to the patient.