摘要:
Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates an output based, at least in part, upon the integrated output, which comprises a value indicating a blood volume that needs be processed to obtain a desired platelet volume.
摘要:
The invention relates to a method for producing a thrombocyte preparation (27) that is low in leucocytes and erythrocytes from a thrombocyte concentrate (26) containing leucocytes and a residual proportion of erythrocytes. The thrombocyte concentrate (26) is initially centrifuged. The thrombocyte concentrate is subsequently filtered using a leucocyte depletion filter (21), beginning with the centrifugal supernatant. The proportion of erythocytes in the thrombocyte concentrate (26) to be filtered is monitored (16) before passing through to the leucocyte depletion filter (21). The entire filter process is terminated when a specific proportion of erythrocytes is obtained.
摘要:
A method for selectively removing leukocytes from a suspension which also contains platelets, such as a platelet concentrate or whole blood. The method includes passing the suspension through a filter which includes a polysaccharide-type coating. The coating may include one or more of hydroxypropylmethyl cellulose, hydroxybutylmethyl cellulose, dextran and hydroxyethyl starch. Also provided is a filter for selectively removing leukocytes from a suspension which also contains platelets. The filter includes a substrate which is coated with a polysaccharide-type composition.
摘要:
A centrifugal separation apparatus for separating whole blood into red blood cells and a plasma constituent carrying platelets is described. The apparatus comprises a separation chamber (10, 31A, 58) which has first and second spaced apart walls (16, 18, 64, 66) that form a separation zone (84) having a low-G side and a high-G side that is located radially further from the rotational axis than the low-G side. The separation zone includes an entry region (122) where the whole blood enters the separation chamber to begin separation into red blood cells toward the high-G side and the plasma constituent toward the low-G side. Inlet and outlet openings (20, 68, 24, 72) are provided that communicate with the separation chamber. The inlet opening provides for the introduction of whole blood into the entry region. The outlet opening (24, 72) directs the plasma constituent from a plasma constituent collection region (124) at the low-G side of the separation zone adjacent the entry region while whole blood is introduced into the entry region through the inlet opening. The apparatus also comprises an interface control system (134) that is located outside the separation chamber and is arranged to monitor the location of an interface (26) that forms between the red blood cells and the plasma constituent during separation by viewing into the separation zone. A method for centrifugally separating whole blood into red blood cells and a plasma constituent carrying platelets is also described.
摘要:
A centrifuge system is disclosed for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel. Delivery systems are mentioned.
摘要:
The present invention provides a method for inactivating nucleic acid strands using broad-spectrum pulsed light. The nucleic acid strands to be inactivated may be in biologically derived compositions, reagents and devices, waste products and in air.
摘要:
A centrifugal separation apparatus for separating whole blood into red blood cells and a plasma constituent carrying platelets is described. The apparatus comprises a separation chamber (10, 31A, 58) which has first and second spaced apart walls (16, 18, 64, 66) that form a separation zone (84) having a low-G side and a high-G side that is located radially further from the rotational axis than the low-G side. The separation zone includes an entry region (122) where the whole blood enters the separation chamber to begin separation into red blood cells toward the high-G side and the plasma constituent toward the low-G side. Inlet and outlet openings (20, 68, 24, 72) are provided that communicate with the separation chamber. The inlet opening provides for the introduction of whole blood into the entry region. The outlet opening (24, 72) directs the plasma constituent from a plasma constituent collection region (124) at the low-G side of the separation zone adjacent the entry region while whole blood is introduced into the entry region through the inlet opening. The apparatus also comprises an interface control system (134) that is located outside the separation chamber and is arranged to monitor the location of an interface (26) that forms between the red blood cells and the plasma constituent during separation by viewing into the separation zone. A method for centrifugally separating whole blood into red blood cells and a plasma constituent carrying platelets is also described.