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31.发明公开METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST 审中-公开方法用于治疗或哮喘的预防通过给予IL-4R拮抗剂
公开(公告)号：EP2888281A1
公开(公告)日：2015-07-01
申请号：EP13759908.0
申请日：2013-08-20
Applicant: SANOFI , Regeneron Pharmaceuticals, Inc.
Inventor： ARDELEANU, Marius , GANDHI, Namita , GRAHAM, Neil , KIRKESSELI, Stephane, C. , KUNDU, Sudeep , RADIN, Allen , ROCKLIN, Ross, E. , WEINSTEIN, Steven , DAVIDSON HAMILTON, Jennifer , MING, Jeffrey
IPC: C07K16/28 , A61K39/395 , C12Q1/68
CPC classification number: C07K16/2866 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K16/247 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6854 , G01N33/6863 , G01N33/6893 , G01N2333/521 , G01N2800/122 , G01N2800/52
Abstract: The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.
Abstract translation: 本发明提供用于治疗或患者中预防哮喘和有关的疾病的方法。 本发明的方法包括给予需要其的治疗组合物，包括白细胞介素4受体（IL-4R）拮抗剂,:的受试者，如抗IL-4R抗体。
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32.发明公开USES OF CXCL17, A NOVEL CHEMOKINE MARKER OF HUMAN LUNG AND GASTROINTESTINAL DISEASE 审中-公开使用CXCL17，人肺和胃肠疾病的一种新型CHEMOKINMARKER的
公开(公告)号：EP2866832A2
公开(公告)日：2015-05-06
申请号：EP13785069.9
申请日：2013-05-03
Applicant: The Regents of the University of California
Inventor： ZLOTNIK, Albert , BURKHARDT, Amanda, M.
IPC: A61K39/395 , A61K48/00 , A61P35/00
CPC classification number: C07K16/24 , A61K39/39 , A61K2039/505 , A61K2039/55516 , C07K2317/54 , C07K2317/55 , C07K2317/569 , C12N15/1136 , C12N2310/11 , C12N2310/14 , G01N33/6863 , G01N33/6884 , G01N2333/521
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公开(公告)号：EP2561366A1
公开(公告)日：2013-02-27
申请号：EP11714786.8
申请日：2011-04-19
Inventor： LAZENNEC, Gwendal , VINDRIEUX, David , MADLY, Brigitte
IPC: G01N33/574 , G01N33/68
CPC classification number: G01N33/57434 , C12Q1/6886 , C12Q2600/158 , G01N33/6863 , G01N2333/521 , G01N2333/522 , G01N2800/52
Abstract: The invention relates to the use of CXCL5 as a marker for assessing hormone escape in prostate cancer cells. The invention further provides diagnostic methods and kits for assessing hormone escape in prostate cancer cells, and CXCL5 antagonists for use in the treatment or prevention of prostate cancer and/or hormone escape in prostate cancer.
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公开(公告)号：EP2201384A2
公开(公告)日：2010-06-30
申请号：EP08830897.8
申请日：2008-09-10
Applicant: Universiteit Leiden , Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center
Inventor： BIESSEN, Ericus Anna Leonardus , VAN BERKEL, Theodorus Josephus Cornelis , KRAAIJEVELD, Adriaan Otto
CPC classification number: G01N33/6863 , C07K14/523 , C07K16/24 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/53 , G01N2333/521 , G01N2333/523 , G01N2500/10 , G01N2800/226 , G01N2800/323 , G01N2800/324 , G01N2800/325 , G01N2800/50 , G01N2800/52 , H01J49/0027 , H01J49/164 , H01J49/40
Abstract: The present invention relates to the identification of chemokine biomarkers predictive of future acute coronary syndromes including unstable angina pectoris (UAP). The present invention also identifies particular chemokines as potential therapeutic targets for intervention in cardiovascular diseases.
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35.发明公开METHODS AND COMPOSITIONS FOR DIAGNOSIS AND/OR PROGNOSIS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES 审中-公开全身炎症反应综合征诊断和/或预后的方法和组合物
公开(公告)号：EP2167962A2
公开(公告)日：2010-03-31
申请号：EP08772206.2
申请日：2008-06-27
Applicant: Biosite Incorporated
Inventor： LEE, Seok-won , RODEMS, Kelline, M. , OELSCHLAGER, David, W. , VEERAMALLU, Uday, Kumar , BUECHLER, Joseph, F. , MCPHERSON, Paul, H.
IPC: G01N33/53
CPC classification number: G01N33/6893 , G01N2333/521 , G01N2800/50 , G01N2800/56
Abstract: The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.
Abstract translation: 本发明涉及用于诊断受试者中的SIRS，败血症，严重败血症，败血症性休克或MODS，或为患有SIRS，败血症，严重败血症，败血症的受试者指定一种或多种临床结果的预后风险的方法和组合物 休克或MODS，所述方法包括对CCL23剪接变体进行免疫测定。
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Patent Agency Ranking36.发明公开
公开(公告)号：EP1356268A2
公开(公告)日：2003-10-29
申请号：EP02713529.2
申请日：2002-02-01
Applicant: THE JOHNS HOPKINS UNIVERSITY
Inventor： JACKMAN, Joany
IPC: G01N27/00
CPC classification number: H01J49/40 , G01N33/569 , G01N33/6848 , G01N33/6851 , G01N33/6863 , G01N33/6869 , G01N2333/521 , H01J49/164 , Y10T436/24
Abstract: The invention is directed to methods suitable for detecting the presence of a plurality of immune system modulators in a complex solution by running a single sample through a mass spectrometer without any surface preparation or preliminary purification step. Immune system modulators that can be analyzed with the methods of the present invention include cytokines (interferons and interleukins), chemokines, host cell response molecules, and peptide fragments. The method also allows the identification of truncated receptors for immune modulators secreted by infected cells or pathogens, such as virokines, and other pathogen-encoded proteins that affect the host immune system.
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公开(公告)号：EP2888281B1
公开(公告)日：2018-09-19
申请号：EP13759908.0
申请日：2013-08-20
Applicant: Sanofi Biotechnology , Regeneron Pharmaceuticals, Inc.
Inventor： ARDELEANU, Marius , GANDHI, Namita , GRAHAM, Neil , KIRKESSELI, Stephane, C. , KUNDU, Sudeep , RADIN, Allen , ROCKLIN, Ross, E. , WEINSTEIN, Steven , DAVIDSON HAMILTON, Jennifer , MING, Jeffrey
IPC: C07K16/28 , A61K39/395 , C12Q1/68
CPC classification number: C07K16/2866 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K16/247 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6854 , G01N33/6863 , G01N33/6893 , G01N2333/521 , G01N2800/122 , G01N2800/52
Abstract: The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.
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公开(公告)号：EP2899545B1
公开(公告)日：2018-08-22
申请号：EP15151607.7
申请日：2011-06-23
Applicant: Astute Medical, Inc.
Inventor： Anderberg, Joseph , Gray, Jeff , McPherson, Paul , Nakamura, Kevin , Kampf, James Patrick
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N33/6854 , G01N33/6863 , G01N33/74 , G01N2333/4725 , G01N2333/4745 , G01N2333/495 , G01N2333/521 , G01N2333/5431 , G01N2333/7155 , G01N2333/96472 , G01N2333/96494 , G01N2800/347 , G01N2800/50 , G01N2800/56
Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of C-C Motif chemokine 24, and optinally Cancer antigen CA 15-3, C-C Motif chemokine 18, , Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.
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39.发明公开
公开(公告)号：EP3210018A4
公开(公告)日：2018-06-20
申请号：EP15853584
申请日：2015-10-20
Applicant: ASTUTE MEDICAL INC
Inventor： ANDERBERG JOSEPH , MCPHERSON PAUL , GRAY JEFF , NAKAMURA KEVIN , KAMPF JAMES PATRICK , KWAN THOMAS
IPC: G01N33/50
CPC classification number: G01N33/6872 , G01N33/6863 , G01N33/6893 , G01N2333/521 , G01N2333/71 , G01N2800/347
Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.
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公开(公告)号：EP2995957B1
公开(公告)日：2017-11-22
申请号：EP15176660.7
申请日：2008-09-10
Applicant: Universiteit Leiden , Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center
Inventor： BIESSEN, Ericus Anna Leonardus , VAN BERKEL, Theodorus Josephus Cornelis , KRAAIJEVELD, Adriaan Otto
CPC classification number: G01N33/6863 , C07K14/523 , C07K16/24 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/53 , G01N2333/521 , G01N2333/523 , G01N2500/10 , G01N2800/226 , G01N2800/323 , G01N2800/324 , G01N2800/325 , G01N2800/50 , G01N2800/52 , H01J49/0027 , H01J49/164 , H01J49/40
Abstract: The present invention relates to the identification of chemokine biomarkers predictive of future acute coronary syndromes including unstable angina pectoris (UAP). The present invention also identifies particular chemokines as potential therapeutic targets for intervention in cardiovascular diseases.
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