公开(公告)号：EP1131080A2

公开(公告)日：2001-09-12

申请号：EP99956072.5

申请日：1999-11-18

申请人： COMPAGNIE GERVAIS-DANONE

发明人： CAYUELA, Chantal ,  DUGAS, Nathalie ,  POSTAIRE, Eric

IPC分类号： A61K35/74 ,  A23C9/123 ,  C12Q1/02 ,  A61P29/00 ,  A61P1/00

CPC分类号： A23C9/1234 ,  A23L33/135 ,  A23Y2220/17 ,  A23Y2240/00 ,  A23Y2300/00 ,  A61K35/747 ,  Y10S436/815 ,  Y10T436/100833 ,  Y10T436/17 ,  Y10T436/177692

摘要： The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said enterocytes. Said strains can also be incorporated in food supplements such as fermented dairy products used for regulating inflammatory response and non-specific immunity.

公开(公告)号：EP0505479B1

公开(公告)日：2001-09-12

申请号：EP91902046.1

申请日：1990-12-14

申请人： Sensor Technologies, Inc.

发明人： CHICK, William, L. ,  WOLF, David, E. ,  CARDULLO, Richard, A

IPC分类号： G01N33/566 ,  G01N33/542 ,  G01N33/66 ,  G01N33/68 ,  G01N33/58 ,  A61K49/00

CPC分类号： A61K49/0041 ,  A61K49/0004 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0056 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  G01N33/68 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/815 ,  Y10T436/144444

公开(公告)号：EP1110091A1

公开(公告)日：2001-06-27

申请号：EP99944686.7

申请日：1999-09-03

申请人： PowderJect Research Limited

发明人： SARPHIE, David, Francis ,  ROBERTS, Lee, Knight ,  FULLER, Deborah, Lynn

IPC分类号： G01N33/68 ,  G01N33/543 ,  G01N33/58 ,  G01N33/50 ,  G01N33/569

CPC分类号： G01N33/5082 ,  A61K49/0006 ,  G01N33/5091 ,  G01N33/54313 ,  G01N33/5695 ,  G01N33/56983 ,  G01N33/585 ,  G01N33/68 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S530/868

摘要： Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the individual are provided.

公开(公告)号：EP0944833B1

公开(公告)日：2001-06-27

申请号：EP97953745.3

申请日：1997-12-05

申请人： Osteometer Biotech AS

发明人： ROSENQUIST, Christian ,  QVIST, Per

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/6887 ,  G01N2800/108 ,  Y10S436/815

摘要： Sandwich assays for collagen degradation products are conducted using an antibody of the same specificity on both sides of the sandwich or using a first antibody reactive with an epitope contained in the sequence EKAHDGGR and a second antibody which may be the same or different.

公开(公告)号：EP0814909B1

公开(公告)日：2001-06-27

申请号：EP97901405.7

申请日：1997-01-10

申请人： DADE BEHRING INC.

发明人： KEGELMAN, Joseph, Edward ,  STILLE, Diane, Kathleen ,  WIEDENMANN, Robert, Kyle ,  ZUK, Paul, John

IPC分类号： B03C1/28 ,  G01N35/00 ,  G01N33/543

CPC分类号： B03C1/288 ,  G01N35/0098 ,  G01N2001/1006 ,  G01N2035/0436 ,  G01N2035/1088 ,  Y10S436/815

摘要： An automatic apparatus for use in assays for separating magnetic particles includes means for separating magnetically responsive particles from a liquid dispersion disposed in a plurality of reaction vessels, and transporting means for transporting the reaction vessels in sequence past at least one processing position. A robotics reagent arm and probe dispense reagents into the reaction vessels and a reaction monitoring device is capable of relative movement with respect to the transporting means. Incomplete separation is effected by positioning a magnetic field in contact with the reaction vessel for a first shortened time interval during which the particles partially aggregate and afterwards removed from the reaction vessel. The magnet is repositioned in contact with the reaction vessel for a third time interval to achieve full separation of particles from the liquid.

公开(公告)号：EP0864086A4

公开(公告)日：2001-05-02

申请号：EP96934005

申请日：1996-10-02

申请人： UNIV COLUMBIA

发明人： WEINBERGER JUDAH

IPC分类号： G01N33/68 ,  G01N33/74 ,  G01N33/53

CPC分类号： G01N33/6887 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/324 ,  Y10S436/811 ,  Y10S436/815

公开(公告)号：EP0580070B1

公开(公告)日：2001-03-14

申请号：EP93111289.0

申请日：1993-07-14

申请人： Johnson & Johnson Clinical Diagnostics, Inc.

发明人： Schaeffer, James Robert ,  Mauck, John Charles, c/o Eastman Kodak Comp. ,  Winterkorn, Robert Francis ,  Arter, Thomas Charles

IPC分类号： C12Q1/34 ,  C12Q1/26

CPC分类号： C12Q1/34 ,  G01N2333/98 ,  Y10S435/966 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/815

公开(公告)号：EP0753583B1

公开(公告)日：2000-10-18

申请号：EP95913411.5

申请日：1995-04-03

申请人： DAIICHI PURE CHEMICALS CO. LTD.

发明人： HINO, Koichi; Daiichi Pure Chemicals Co., Ltd. ,  NAKAMURA, Mitsuhiro Daiichi Pure Chemicals Co., ,  MANABE, Mitsuhisa Daiichi Pure Chemicals Co.,

IPC分类号： C12Q1/60 ,  C12Q1/44 ,  C12Q1/26 ,  G01N33/92

CPC分类号： G01N33/92 ,  C12Q1/60 ,  Y10S435/962 ,  Y10S436/815 ,  Y10S436/824 ,  Y10S436/825 ,  Y10S436/826 ,  Y10T436/104165 ,  Y10T436/107497 ,  Y10T436/25

摘要： A method of quantitative analysis of cholesterol contained in a high-specific-gravity lipoprotein by adding to a lipoprotein-containing specimen a substance which forms a complex with a lipoprotein other than the high-specific-gravity lipoprotein and a surfactant, and enzymatically determining the cholesterol content. The method permits the quantitative analysis of cholesterol contained in a high-specific-gravity lipoprotein with a simple operation at a high efficiency without the necessity for pre-treatment such as centrifugal separation. This method is applicable to various automatic analyzers and useful also in the field of clinical examination.

公开(公告)号：EP0641439B1

公开(公告)日：2000-09-13

申请号：EP92917086.8

申请日：1992-07-29

申请人： ABBOTT LABORATORIES

发明人： ADAMCZYK, Maciej ,  JOHNSON, Donald ,  HARRINGTON, Charles, A.

IPC分类号： G01N33/533 ,  G01N33/94 ,  C07D223/28

CPC分类号： G01N33/533 ,  C07D223/28 ,  G01N33/9466 ,  Y10S436/815 ,  Y10S530/807

摘要： Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are disclosed. The measurement of imipramine or desipramine is accomplished in a specific immunoassay employing antibodies prepared with imipramine or desipramine derivatives of formula (III), wherein P is an immunogenic carrier material, X is two heteroatoms, Y is a linking group comprising from 1 to 6 carbon atoms and P is an immunogenic carrier material, and wherein for imipramine, R is CH3, and for desipramine, R is H. The present invention also describes the synthesis of unique labeled reagents of the structure of formula (IV), wherein Z is a linking group comprising 1 to 4 carbon atoms and 0 to 2 heteroatoms and Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and wherein for imipramine, R1 is CH3, and for desipramine, R1 is H.

公开(公告)号：EP0643834B1

公开(公告)日：2000-08-16

申请号：EP92920466.7

申请日：1992-09-14

申请人： LA MINA LTD.

发明人： GUIRGUIS, Raouf, A.

IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N33/94 ,  A61B5/117

CPC分类号： A61B5/1172 ,  A61B5/117 ,  A61B10/0051 ,  A61B2010/0009 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/94 ,  Y10S436/80 ,  Y10S436/81 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/817 ,  Y10S436/901

摘要： A method and device for testing for the presence of substances such as drugs in body fluids while simultaneously positively identifying the test subject. The device comprises an absorbent pad and a membrane mounted to the absorbent pad containing a plurality of separated areas provided with different immobilized ligand having a specific receptor site for capture or rejection of specific antigens produced by different predetermined drugs. The method of testing comprises the steps of: (a) obtaining a quantity of body fluid in a container, (b) adding an antibody to the body fluid to form a mixed solution, (c) placing the mixed solution on a membrane and absorbent pad device and immobilized ligands, (d) covering the finger with a thin film of labelled antibody and (e) placing the finger on the membrane containing immobilized ligand specifically selected to bind to labelled antibody presenting the fingerprint of the test subject, the presence or absense of substances being tested for in the body fluid so that solution is deposited from the finger on the membrane indicating presence or absence of the substance.