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31.发明授权Process for the preparation of 3-exomethylenecepham sulfoxide derivatives and intermediates therefor 失效一种用于3-Exomethylencephamsulfoxydderivate和中间体化合物的制备方法
公开(公告)号：EP0389064B1
公开(公告)日：1997-04-09
申请号：EP90200684.0
申请日：1990-03-21
申请人： GIST-BROCADES N.V.
IPC分类号： C07D501/10 , C07D205/09
CPC分类号： C07D205/095 , C07D501/00
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公开(公告)号：EP0503604B1
公开(公告)日：1996-12-27
申请号：EP92104201.6
申请日：1992-03-11
发明人： Torii, Sigeru , Tanaka, Hideo , Taniguchi, Masatoshi, c/o Otsuka Kagaku K.K. , Sasaoka, Michio, c/o Otsuka Kagaku K.K. , Shiroi, Takashi, c/o Otsuka Kagaku K.K. , Kameyama, Yutaka, c/o Otsuka Kagaku K.K.
IPC分类号： C07D205/095 , C07D205/09
CPC分类号： C07D205/095 , C07D205/09 , Y02P20/55
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公开(公告)号：EP0365223B1
公开(公告)日：1996-09-04
申请号：EP89310500.7
申请日：1989-10-12
申请人： PFIZER INC.
IPC分类号： C07D499/88 , C07D205/09 , C07F7/18
CPC分类号： C07D205/09 , C07D499/88
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34.发明公开TAXANES HAVING FURYL OR THIENYL SUBSTITUTED SIDE-CHAIN 失效紫杉烷MIT FuryL-ODER THIENYL SUBSTITUIERTEN SEITENKETTEN
公开(公告)号：EP0690867A4
公开(公告)日：1996-03-20
申请号：EP94911675
申请日：1994-03-21
申请人： UNIV FLORIDA STATE
发明人： HOLTON ROBERT A , NADIZADEH HOSSAIN , BIEDIGER RONALD J , RENGAN KASTHURI , SUZUKI YUKIO , TAO CHUNLIN , CHAI KI-BYUNG , IDMOUMAZ HAMID
IPC分类号： C07D333/20 , A61K31/335 , A61K31/337 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P35/00 , A61P35/02 , C07C227/22 , C07C231/12 , C07C233/87 , C07D205/08 , C07D205/085 , C07D205/09 , C07D305/14 , C07D307/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/00 , C07D407/12 , C07D407/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07F7/08 , C07F7/18
CPC分类号： C07D407/12 , C07C227/22 , C07C231/12 , C07C233/87 , C07C2601/14 , C07C2601/16 , C07C2603/62 , C07D205/08 , C07D305/14 , C07D405/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07F7/1856 , C07F7/186 , Y02P20/55
摘要： Taxane derivatives having a C13 side chain which includes a furyl or thienyl substituent.
摘要翻译： 具有包含呋喃基或噻吩基取代基的C13侧链的紫杉烷衍生物。
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35.发明公开Beta-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF 失效Beta-Laktam和Cepham Verbindungen und Ihre Herstellung。
公开(公告)号：EP0592677A1
公开(公告)日：1994-04-20
申请号：EP93903302.3
申请日：1993-02-03
发明人： TORII, Shigeru 4-18, Sanyodanchi 4-chome , TANAKA, Hideo 5115-34, Haga , SASAOKA, Mitio 1-16, Nakanokoshi , SHIROI, Takashi 51-41, Aza Nishinosu Tainohama , KAMEYAMA, Yutaka 24-19-406, Okudahonmachi
IPC分类号： C07D205/08 , C07D501/00 , C07D501/18 , C07D501/22 , C07D501/57 , C07D501/60 , C07D205/09 , C07D205/095
CPC分类号： C07D205/09 , C07D205/095 , C07D501/00 , Y02P20/55
摘要： A β-lactam compound and a 2-(substituted methyl)-3-cephem compound, both being useful as an intermediate for the synthesis of cephem antibiotics and so forth. The lactam compound is represented by general formula (I), wherein R¹ represents protected amino, etc.; R² represents hydrogen, etc.; R³ represents hydrogen or a protective group for a carboxyl group; R⁴ represents optionally substituted aryl; and R⁵ represents optionally substituted alkenyl, etc. The cephem compound is represented by general formula (II), wherein R¹, R² and R³ are each as defined above; and R⁶ represents optionally substituted aryl.
摘要翻译： β-内酰胺化合物和2-（取代的甲基）-3-头孢烯化合物都可用作合成头孢烯抗生素等的中间体。 内酰胺化合物由通式（I）表示，其中R 1表示被保护的氨基等; R 2表示氢等; R 3表示氢或羧基的保护基; R 4表示任选取代的芳基; 并且R 5表示任选取代的烯基等。头孢烯化合物由通式（II）表示，其中R 1，R 2和R 3各自如上所定义; 且R 6表示任选取代的芳基。
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36.发明公开4-Oxo-azetidine-2-sulfonic acids and their salts, processes for the preparation thereof and their use 失效4-OXO-AZETIDINE-2-SULFONIC酸及其盐，其制备方法及其使用
公开(公告)号：EP0499232A3
公开(公告)日：1992-12-02
申请号：EP92102335.4
申请日：1992-02-12
发明人： Kovacevic, Mice, Dr. , Mandic, Zorica , Tomic, Mirjana , Brkic, Zinka , Herak, Jure, Dr. , Lukic, Irena
IPC分类号： C07D205/095 , C07D205/09 , C07D403/04 , C07D413/12 , A61K31/395
CPC分类号： C07D403/04 , C07D205/09 , C07D205/095 , C07D413/10
摘要： The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I
wherein:
R¹ = hydrogen, halogen, phenylacetamido; R² = hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-methyl-3- o -chlorophenyl-isoxazole-4-carboxamido; R³ = hydrogen, alkali metal, alkaline earth metal, quaternary ammonium group; R⁴ = hydrogen, SO₂O ⁻⁺ NBu₄- n ,
(CH₃)₂C=C-COOCH₃,
(CH₃)₂C=C-COOCH₂Ph,
(CH₃)₂C=C-COOCH₂-C₆H₄-NO₂- p ,
(CH₃)₂C=C-COOCH₂-C₆H₄-CH₃- m . The products (I) may be used as intermediates in the synthesis of beta-lactamic antibiotics or as components in antimicrobial preparations.-
37.发明公开Allenyl beta-lactam compounds and process for preparing same 失效烯丙基-β-内酰胺醛酸丁酯和Verfahren zu deren Herstellung。
公开(公告)号：EP0503604A2
公开(公告)日：1992-09-16
申请号：EP92104201.6
申请日：1992-03-11
发明人： Torii, Sigeru , Tanaka, Hideo , Taniguchi, Masatoshi, c/o Otsuka Kagaku K.K. , Sasaoka, Michio, c/o Otsuka Kagaku K.K. , Shiroi, Takashi, c/o Otsuka Kagaku K.K. , Kameyama, Yutaka, c/o Otsuka Kagaku K.K.
IPC分类号： C07D205/095 , C07D205/09
CPC分类号： C07D205/095 , C07D205/09 , Y02P20/55
摘要： The present invention provides an allenyl β -lactam compound represented by the formula (1)
wherein R¹ is a hydrogen atom, halogen atom, amino or protected amino, R² is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, lower alkyl, lower alkyl substituted with hydroxyl or protected hydroxyl, hydroxyl or protected hydroxyl, R¹ and R² representing =O when taken together, R³ is a hydrogen atom or carboxylic acid protecting group, and X is the group -SO₂R⁴ or the group -SR⁴, R⁴ being substituted or unsubstituted aryl or substituted or unsubstituted nitrogen-containing aromatic heterocyclic group.摘要翻译： 本发明提供由式（1）表示的丙烯基β-内酰胺化合物
其中R 1是氢原子，卤素原子，氨基或保护的氨基，R 2是氢原子，卤素原子， 低级烷氧基，低级酰基，低级烷基，被羟基或被保护的羟基取代的低级烷基，羟基或被保护的羟基，R 1和R 2一起代表= O，R 3是氢原子或羧酸 X为-SO 2 R 4基或-SR 4基，R 4为取代或未取代的芳基或取代或未取代的含氮芳香族杂环基。
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