公开(公告)号：EP0741144B1

公开(公告)日：2002-07-24

申请号：EP95936774.9

申请日：1995-11-10

申请人： Kaneko, Noboru

发明人： KANEKO, Noboru ,  MATSUDA, Ryuko ,  KAJITA,Tadahiro International Reagents Corporation ,  OHTA, Yohsuke International Reagents Corporation

IPC分类号： C07K16/18 ,  C12P21/08 ,  C12N15/06 ,  C12N5/20 ,  G01N33/577

CPC分类号： C07K16/18 ,  G01N2333/4718

公开(公告)号：EP0882799A4

公开(公告)日：2002-05-29

申请号：EP97913427

申请日：1997-11-21

申请人： KYOWA HAKKO KOGYO KK

发明人： SHITARA KENYA ,  ITO MIKITO ,  HANAI NOBUO ,  SHIBUYA MASABUMI

IPC分类号： A61K38/00 ,  C07K16/28 ,  G01N33/574 ,  G01N33/68 ,  G01N33/74 ,  C12P21/02 ,  A61K39/395 ,  C12N5/16 ,  C12N5/20 ,  C12N15/06 ,  G01N33/53 ,  G01N33/577

CPC分类号： G01N33/74 ,  A61K38/00 ,  C07K16/2803 ,  G01N33/57407 ,  G01N33/6893

摘要： A monoclonal antibody which immunologically reacts with human VEGF receptor F1t-1, cells having the human VEGF receptor F1t-1, expressed thereon, and the like; a monoclonal antibody having an inhibitory activity against the binding of human VEGF to human VEGF receptor F1t-1; and the diagnosis and treatment of diseases wherein the pathological condition advances by abnormal vascularization, such as propagation and metastasis of solid tumors, arthritis in chronic articular rheumatism, diabetic retinopathy, prematurity retinopathy and psoriasis, by using the monoclonal antibody.

公开(公告)号：EP0903149A4

公开(公告)日：2002-02-13

申请号：EP97906844

申请日：1997-03-06

申请人： CHUGAI PHARMACEUTICAL CO LTD

发明人： FUKUSHIMA NAOSHI

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N15/06 ,  A61K39/395 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K14/70596 ,  A61K38/00 ,  C07K14/4747

摘要： A method of screening apoptosis inducing substances characterized by using cells where an integrin-associated protein (IAP) has been expressed; the above screening method wherein the cells used are myelocytic cells; and pharmaceutical compositions containing as the active ingredient the substances obtained by the above method. The invention makes it possible to differentiate, identify and screen readily and highly efficiently the substances, such as antibodies, that induce apoptosis in myelocytic cells by using cells wherein IAP has been expressed while utilizing specific binding reactions of the substances. The above-specified substances thus obtained can be used by virtue of their characteristics as the active ingredient of pharmaceutical compositions such as anticancer agents and remedies for myelocytic leukemia.

摘要翻译： 筛选细胞凋亡诱导物质的方法，其特征在于使用已经表达整联蛋白相关蛋白（IAP）的细胞; 上述筛选方法，其中使用的细胞是髓细胞; 以及含有通过上述方法得到的物质作为有效成分的药物组合物。 本发明通过使用其中IAP已被表达同时利用所述物质的特异性结合反应而表达的细胞，能够容易且高效地分化，鉴定和筛选诱导髓细胞细胞凋亡的物质，例如抗体。 由于其作为药物组合物的有效成分如抗癌剂和治疗髓细胞性白血病的特性，可以使用由此获得的上述物质。

公开(公告)号：EP0812859B1

公开(公告)日：2002-02-13

申请号：EP96943313.5

申请日：1996-12-26

申请人： IATRON LABORATORIES, INC. ,  Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

发明人： KOHNO, Isao Iatron Laboratories, Inc. ,  ITOH, Yumiko Iatron Laboratories, Inc. ,  KUMETA, Kosuke ,  KAMIKUBO, Yuichi ,  SOE, Gilbu Iatron Laboratories, Inc.

IPC分类号： C07K16/36 ,  C12P21/08 ,  C12N15/06 ,  C12N5/18 ,  G01N33/53 ,  G01N33/577 ,  C07K16/40 ,  C07K16/38

CPC分类号： G01N33/573 ,  C07K16/36 ,  C07K16/40 ,  G01N33/86 ,  G01N2333/811 ,  G01N2333/8114 ,  G01N2333/96444

摘要： A monoclonal antibody reacting specifically with the factor Xa-tissue factor pathway inhibitor complex (Xa.TFPI) but not with free factor X, free factor Xa and free tissue factor pathway inhibitor (TFPI); a hybridoma excreting this monoclonal antibody; and a method for immunologically assaying the factor Xa-tissue factor pathway inhibitor complex by using this monoclonal antibody.

公开(公告)号：EP1176194A1

公开(公告)日：2002-01-30

申请号：EP00925602.5

申请日：2000-05-10

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： OZAKI, Yasuko Chugai Seiyaku Kabushiki Kaisha ,  KOISHIHARA, Yasuo Chugai Seiyaku Kabushiki Kaisha ,  KAIHO, Shin-ichi Chugai Seiyaku Kabushiki Kaisha

IPC分类号： C12N15/06 ,  C12N15/09 ,  C12N5/10 ,  C12N5/16

CPC分类号： C07K16/00 ,  C12N2502/00 ,  C12N2510/02

摘要： A method of culturing a protein-producing cell, said method comprising co-culturing one transformed cell that can constitutively produce said protein with the parent cell of said transformed cell.

摘要翻译： 培养蛋白质生成细胞的方法，所述方法包括共培养可以与所述转化细胞的亲本细胞组成型产生所述蛋白质的一个转化细胞。

公开(公告)号：EP1067834A4

公开(公告)日：2002-01-23

申请号：EP99910012

申请日：1999-03-16

申请人： GARELAG PTY LTD

发明人： VERMA PAUL JOHN ,  NOTTLE MARK BRENTON

IPC分类号： A01K67/02 ,  A61K35/54 ,  C12N15/02 ,  C12N15/877 ,  A01K67/00 ,  C12N15/06

CPC分类号： C12N15/8778

公开(公告)号：EP1152057A1

公开(公告)日：2001-11-07

申请号：EP00979079.1

申请日：2000-12-04

申请人： TEIJIN LIMITED

发明人： EGUCHI, Hiroshi, Teijin Limited ,  YAMAOKA, Kazuyoshi, Teijin Limited ,  OGAWA, Hiroko, Teijin Limited ,  YASUOKA, Susumu, School of Medical Science

IPC分类号： C12N15/06 ,  C12N5/10 ,  C07K16/40 ,  C12Q1/37 ,  A61K39/395 ,  A61P11/00 ,  A61P11/04 ,  A61P11/06 ,  A61P11/10 ,  A61P31/12 ,  A61P35/00 ,  A61P35/04 ,  G01N33/573 ,  G01N33/577

CPC分类号： G01N33/573 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/55 ,  G01N2333/976

摘要： Problems of the present invention are to provide methods for diagnosing the morbid state based on the assay of a human airway trypsin-like protease in a biosample and to provide a therapeutic agent for diseases associated with the human airway trypsin-like protease.
Such problems are solved with antibodies binding to the human airway trypsin-like protease and an enzyme immunoassay using the antibodies. Furthermore, the problems are solved with a therapeutic agent comprising the antibodies inhibiting the activation of the human airway trypsin-like protease and a therapeutic agent comprising the antibodies neutralizing the human airway trypsin-like protease activity.

摘要翻译： 本发明的问题在于提供一种基于生物样品中人气道胰蛋白酶样蛋白酶的测定来诊断病态的方法，并提供与人气道胰蛋白酶样蛋白酶相关的疾病的治疗剂。 利用与人气道胰蛋白酶样蛋白酶结合的抗体和使用抗体的酶免疫测定可以解决这些问题。 此外，通过包含抑制人气道胰蛋白酶样蛋白酶活化的抗体的治疗剂和包含中和人气道胰蛋白酶样蛋白酶活性的抗体的治疗剂来解决问题。

公开(公告)号：EP1149844A2

公开(公告)日：2001-10-31

申请号：EP01303411.1

申请日：2001-04-11

申请人： Riken

发明人： Mikoshiba, Katsuhiko ,  Tabata, Hidenori ,  Nakajima, Kazunori

IPC分类号： C07K14/46 ,  C07K14/47 ,  C12N15/06

CPC分类号： C07K14/463 ,  A61K38/00 ,  C07K14/705

摘要： The present invention provides a truncated Reelin protein containing a F-spondin domain and a CR-50 recognition site but containing no repeat site of a Reelin protein, and a DNA encoding the truncated Reelin protein. The truncated Reelin protein and the DNA encoding this protein of the present invention can be utilized for treatment of diseases including agyria due to abnormal alignment of neurons.

摘要翻译： 本发明提供了含有F-螺蛋白结构域和CR-50识别位点但不含有Reelin蛋白重复位点的截短的Reelin蛋白，以及编码截短的Reelin蛋白的DNA。 截短的Reelin蛋白和编码本发明蛋白质的DNA可用于治疗由于神经元异常排列而引起的疾病，包括谷氨酰胺。

公开(公告)号：EP1147174A1

公开(公告)日：2001-10-24

申请号：EP99965105.2

申请日：1999-12-06

申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION

发明人： BROWSE, John, A. ,  WALLIS, James, G. ,  WATTS, Jennifer, L.

IPC分类号： C12N1/10 ,  C12N1/12 ,  C12N9/00 ,  C12N15/06 ,  C12N15/09 ,  C12N15/12 ,  C12N15/30

CPC分类号： C12N9/0071 ,  A01K2217/05 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472

摘要： The amino acid and nucleic acid sequences of a Δ5-desaturase enzyme and a Δ8-desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant DNA constructs and vectors. These vectors can then be used to transform various organisms, including for example, plants and yeast. The transformed organisms will then produce polyunsaturated fatty acids. The amino acid sequences are useful for generating enzyme-specific antibodies that are useful for identifying the desaturases.

公开(公告)号：EP0888046A4

公开(公告)日：2001-10-04

申请号：EP97903809

申请日：1997-01-21

申请人： PAIK KYE HYUNG

发明人： PAIK KYE-HYUNG

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C12N5/07 ,  C12N5/10 ,  C12N7/00 ,  C12N7/02 ,  C12N15/00 ,  C12N15/06 ,  C12N15/86 ,  C12P21/02 ,  A01N1/02 ,  C12N5/06 ,  C12N5/08 ,  C12P21/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2730/10122 ,  C12N2730/10143 ,  C12N2770/24222 ,  C12N2770/32422 ,  C12N2799/021 ,  C12N2800/108 ,  C12P21/02

摘要： A method of producing viral antigens in vitro by infecting animal organ tissue rich in mitochondria with a virus, including human hepatitis B virus (HBV), and culturing the infected tissue in vitro is disclosed. A method of producing proteins in vitro by transfecting mitochondria-rich animal tissue with a recombinant HBV-based vector and culturing the transfected tissue in a dynamic tissue culture system is disclosed.