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    GALACTOPYRANOSYL DERIVATIVES USEFUL AS MEDICAMENTS
    38.
    发明公开
    GALACTOPYRANOSYL DERIVATIVES USEFUL AS MEDICAMENTS 审中-公开
    作为药物的半乳糖吡喃糖苷衍生物

    公开(公告)号：EP3296309A1

    公开(公告)日：2018-03-21

    申请号：EP17178121.4

    申请日：2013-06-20

    申请人： Universiteit Gent

    发明人： ELEWAUT, Dirk ,  PAUWELS, Nora ,  ASPESLAGH, Sandrine ,  VAN CALENBERGH, Serge

    IPC分类号： C07H15/04 ,  A61K31/7032 ,  A61P31/00 ,  A61P35/00

    CPC分类号： C07H15/26 ,  C07H15/04 ,  C07H15/18

    摘要： This invention relates to carbamate-containing or thiocarbamate-containing galacto-pyranosyl compounds useful as therapeutic agents and being represented by the structural formula (II), wherein: X is O or S, R is selected from the group consisting of C1-8 alkyl, C3-10 cycloalkyl, aryl-C1-4 alkyl, heterocyclyl-C1-4 alkyl, cycloalkyl-C1-4 alkyl, aryl and heterocyclyl, wherein R is optionally substituted with one or more R9; R2, R3, R4, R6 and R7 are independently selected from the group consisting of hydroxyl and protected hydroxyl groups; R5 is selected from the group consisting C6-30 alkyl and arylalkyl; R8 is C6-30 alkyl; and each R9 is independently selected from the group consisting of halogen, hydroxy, trifluoromethyl, trifluoromethoxy, C1-8 alkoxy, C1-6 alkyl, cyano, methylthio, phenyl, phenoxy, chloromethyl, dichloromethyl, chloro-difluoromethyl, acetyl, nitro, benzyl, heterocyclyl and di-C1-4 alkyl-amino, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及用作治疗剂的含氨基甲酸酯或硫代氨基甲酸酯的半乳糖 - 吡喃糖基化合物，其由结构式（II）表示，其中：X是O或S，R选自C 1-8烷基 ，C 3-10环烷基，芳基-C 1-4烷基，杂环基-C 1-4烷基，环烷基-C 1-4烷基，芳基和杂环基，其中R任选被一个或多个R 9取代; R2，R3，R4，R6和R7独立地选自羟基和被保护的羟基; R5选自C6-30烷基和芳基烷基; R8是C6-30烷基; 每个R9独立地选自卤素，羟基，三氟甲基，三氟甲氧基，C1-8烷氧基，C1-6烷基，氰基，甲硫基，苯基，苯氧基，氯甲基，二氯甲基，氯二氟甲基，乙酰基，硝基，苄基 ，杂环基和二-C 1-4烷基 - 氨基，或其药学上可接受的盐。