公开(公告)号：EP2137525A1

公开(公告)日：2009-12-30

申请号：EP07723501.8

申请日：2007-03-22

申请人： GE Healthcare Bio-Sciences AB

发明人： WILLIAMS, Alan ,  NORDBERG, Roger

IPC分类号： G01N30/56

摘要： The present invention relates to methods and apparatus for forming an homogeneous mixture of chromatography media in a vessel. The invention also relates to methods and apparatus for transferring the homogeneous media from the vessel into a second vessel in preparation for packing a chromatography column. The invention can also be used directly to pack the column with homogeneous media.

公开(公告)号：EP1938094A2

公开(公告)日：2008-07-02

申请号：EP06818266.6

申请日：2006-10-20

申请人： GE Healthcare Bio-Sciences AB

发明人： WINDAHL, Kristian

IPC分类号： G01N30/50 ,  G01N30/56 ,  B01D15/20 ,  G01N30/52 ,  B01D15/12

CPC分类号： G01N30/56 ,  B01D15/206 ,  G01N30/6021 ,  G01N2030/565

摘要： A column packing system comprises a control unit provided with software for monitoring the column interior pressure and/or flow through the column for use in calculating the breakpoint where a movable adapter comes into contact with a consolidated bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the movable adapter has to move into the column in order to achieve a desired amount of bed compression.

公开(公告)号：EP1859848A1

公开(公告)日：2007-11-28

申请号：EP07014835.8

申请日：2006-03-03

申请人： MILLIPORE CORPORATION

发明人： Perreault, Jeremy ,  Carroll, Mark ,  Noyes, Aaron

IPC分类号： B01D15/20 ,  G01N30/56

CPC分类号： B01D15/206 ,  B01D15/20 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/522

摘要： The present invention provides an automated system and method for packing chromatography columns. In one embodiment, the system first determines the type of media that is present in the column, and uses this information to generate an automated procedure to pack the specific media type. In a second embodiment, the media type is made known to the system, such as via input from the operator. The system then uses this information, in the same manner as in the first embodiment, to generate an automated procedure to pack the specific media type. Finally, in a third embodiment, parameters such as column height and rate of compression are made known to the system, such as via input from the operator. The system then packs the column in accordance with these supplied parameters.

摘要翻译： 本发明提供一种用于填充色谱柱的自动化系统和方法。 在一个实施例中，系统首先确定列中存在的媒体的类型，并且使用该信息来生成用于打包特定媒体类型的自动化过程。 在第二实施例中，媒体类型对于系统是已知的，例如通过来自操作者的输入。 然后，系统以与第一实施例中相同的方式使用该信息来生成用于打包特定媒体类型的自动化过程。 最后，在第三实施例中，例如通过来自操作者的输入，诸如列高度和压缩速率的参数对于系统是已知的。 系统然后根据这些提供的参数包装色谱柱。

公开(公告)号：EP1859035A1

公开(公告)日：2007-11-28

申请号：EP05711230.2

申请日：2005-03-08

申请人： Agency for Science, Technology and Research

发明人： YING, Jackie, Y. ,  LEE, Su Seong ,  HAN, Yu

IPC分类号： C12N11/00 ,  C12N11/14 ,  G01N30/56

CPC分类号： C07K17/14 ,  C12N11/14 ,  C12P1/00 ,  Y02P20/588

摘要： The present invention relates to a method for immobilizing enzymes in a solid porous support, and to enzymes immobilized in solid porous supports. Specifically, the present invention uses a fluid containing the enzyme under high pressure (such as 25 to 50 Mpa) to immobilize the enzyme (such as CALB) on the porous support (such as silica). The resulting porous support contain more immobilized enzyme than would otherwise have been obtained by a process carried out at atmospheric pressures.

公开(公告)号：EP1630190B1

公开(公告)日：2007-09-12

申请号：EP05254643.9

申请日：2005-07-26

申请人： Agilent Technologies, Inc.

发明人： Lautamo, Roy M.A.

IPC分类号： C08G77/12 ,  C08G77/48 ,  C08G77/50 ,  C08G77/52 ,  C07F7/08 ,  C07F7/18 ,  G01N30/56

CPC分类号： C08G77/485 ,  C07F7/0849 ,  C08G77/50 ,  G01N30/56 ,  G01N30/6078 ,  G01N2030/567

公开(公告)号：EP1754053A1

公开(公告)日：2007-02-21

申请号：EP05743147.0

申请日：2005-05-10

申请人： Merck Patent GmbH

发明人： LUBDA, Dieter ,  CABRERA, Karin

IPC分类号： G01N30/60 ,  G01N30/56 ,  B01D15/08

CPC分类号： G01N30/6078 ,  B01D15/08 ,  G01N30/56 ,  G01N2030/567

摘要： The invention relates to a method for producing open tubular capillaries containing monolithic sorbents and to said capillaries. The inventive capillaries are characterised by a connection layer between the capillary wall and the sorbent, said layer ensuring a particularly good adhesion of the sorbent to the capillary wall.

公开(公告)号：EP1584922A3

公开(公告)日：2006-04-12

申请号：EP05252222.4

申请日：2005-04-08

申请人： Agilent Technologies Inc

发明人： Yin, Hongfeng ,  Killeen, Kevin P. ,  Brennen, Reid A. ,  Effelsberg, Uwe

IPC分类号： G01N30/56

CPC分类号： G01N30/56 ,  B01J2219/00466 ,  G01N2030/565 ,  G01N2035/00574

摘要： Provided are apparatuses and methods for introducing particles into a microdevice conduit (31). Also provided are microdevices (10) containing a plurality of particles that occupy at least about 25 volume percent of microconduit. In some instances, particles may controllably form a particle bridge in a bridging zone within a microdevice.

公开(公告)号：EP1584922A2

公开(公告)日：2005-10-12

申请号：EP05252222.4

申请日：2005-04-08

申请人： Agilent Technologies Inc

发明人： Yin, Hongfeng ,  Killeen, Kevin P. ,  Brennen, Reid A. ,  Effelsberg, Uwe

IPC分类号： G01N30/56

CPC分类号： G01N30/56 ,  B01J2219/00466 ,  G01N2030/565 ,  G01N2035/00574

摘要： Provided are apparatuses and methods for introducing particles into a microdevice conduit (31). Also provided are microdevices (10) containing a plurality of particles that occupy at least about 25 volume percent of microconduit. In some instances, particles may controllably form a particle bridge in a bridging zone within a microdevice.

摘要翻译： 提供了将颗粒引入微型设备导管（31）中的装置和方法。 还提供了包含占据至少约25体积％微管的多个颗粒的微器件（10）。 在一些情况下，颗粒可以可控地形成微型装置内的桥接区域中的颗粒桥。

公开(公告)号：EP1383923A4

公开(公告)日：2005-07-13

申请号：EP02728606

申请日：2002-03-29

申请人： UNIV COLUMBIA

发明人： JU JINGYUE ,  EDWARDS JOHN ROBERT ,  LI ZENGMIN

IPC分类号： G01N27/62 ,  B01J20/281 ,  B01J20/283 ,  C07H21/04 ,  C12Q1/68 ,  G01N27/64 ,  G01N30/00 ,  G01N30/46 ,  G01N30/56 ,  G01N30/60 ,  G01N30/88 ,  G01N33/50

CPC分类号： C12Q1/6872 ,  Y02C10/08 ,  C12Q2535/101

摘要： This invention provides methods for sequencing DNA by detecting the identity of a nucleotide within a DNA sequencing fragment using mass spectrometry. The invention provides cleavable linkers for attaching a label to a dideoxynucleotide and provides labeled dideoxynucleotides. The invention also provides methods for increasing mass spectrometry resolution using linkers with different mass. The invention further provides systems for separating a labeled moiety from non-labeled components in one or more samples in solution.

公开(公告)号：EP1507588A1

公开(公告)日：2005-02-23

申请号：EP03724707.9

申请日：2003-05-06

申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

发明人： HARRISON, D., Jed ,  JEMERE, Abebaw, Belay

IPC分类号： B01L3/00 ,  G01N1/40 ,  G01N27/447 ,  G01N30/56

CPC分类号： G01N30/56 ,  B01L2200/0678 ,  B01L2300/041 ,  B01L2400/0415 ,  G01N30/6095 ,  G01N2030/285 ,  G01N2030/565

摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors. The system comprises two weirs (6, 7) in a channel to trap packing material (12). The packing material might be introduced through a side channel to the chamber formed between the two weirs (6, 7). A plug is positioned in the side channel to close it.