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公开(公告)号：EP1578430A4
公开(公告)日：2008-04-23
申请号：EP03796687
申请日：2003-12-05
申请人： FIBROGEN INC
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/437 , A61K31/44 , A61K31/4425 , A61K31/47 , A61K31/472 , A61K31/4745 , A61K31/502
摘要： The present invention relates to compounds that stabilizes HIF± for use in a) treating or preventing hypertension; or b) decreasing blood triglyceride levels in a mammalian subject.
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公开(公告)号：EP1885756A2
公开(公告)日：2008-02-13
申请号：EP06759334.3
申请日：2006-05-05
申请人： FIBROGEN, INC.
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505
摘要： The present invention relates to methods and agents for treating impaired vascular and cardiac function. Methods and agents for treating various physiological and pathological features associated with vascular dysfunction and cardiac dysfunction are also provided.
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公开(公告)号：EP1232182B1
公开(公告)日：2007-10-03
申请号：EP00978456.2
申请日：2000-11-10
申请人： FIBROGEN, INC.
CPC分类号： C07K14/78 , C12N15/8257
摘要： The present invention provides animal collagens and gelatins and compositions thereof, and methods of producing the same.
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公开(公告)号：EP1434993A4
公开(公告)日：2006-11-29
申请号：EP02761695
申请日：2002-09-18
申请人： FIBROGEN INC
发明人： WEITZ STEPHEN L , USINGER WILLIAM R
IPC分类号： G01N33/53 , G01N33/74 , C07K14/475 , C12N15/09 , G01N33/68
CPC分类号： G01N33/6887 , G01N33/74
摘要： The present invention relates to methods of detection and quantitation of connective tissue growth factor (CTGF), and diagnosis and detection of various CTGF-associated diseases and disorders.
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公开(公告)号：EP1463823A4
公开(公告)日：2005-11-16
申请号：EP02805548
申请日：2002-12-06
申请人： FIBROGEN INC
发明人： KLAUS STEPHEN J , LIN AL Y , NEFF THOMAS B , WANG QINGJIAN , GUENZLER-PUKALL VOLKMAR , AREND MICHAEL P , FLIPPIN LEE A
IPC分类号： G01N33/50 , A61K31/00 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4745 , A61K31/496 , A61K31/555 , A61K31/63 , A61K33/26 , A61K38/00 , A61K38/17 , A61K38/22 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P17/02 , A61P25/00 , A61P25/08 , A61P43/00 , C07K14/47 , C07K14/505 , C12N5/06 , C12N9/99 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , C12Q1/34 , C12Q1/56
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP1463531A1
公开(公告)日：2004-10-06
申请号：EP02804786.8
申请日：2002-12-11
IPC分类号： A61K48/00 , A61K39/395 , G01N33/53
CPC分类号： G01N33/6887 , A61K48/00 , A61K2039/505 , A61K2039/54 , C07K14/475 , C07K16/22 , C12N2799/022 , G01N2333/475
摘要： The present invention relates to methods for inhibiting or preventing ocular processes associated with CTGF. Methods and agents for use in treating or preventing ocular disorders, methods for diagnosing ocular disorders and related kits, and methods for screening for agents for use in the present methods are also provided.
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47.发明公开COLLAGEN TYPE I AND TYPE III HEMOSTATIC COMPOSITIONS FOR USE AS A VASCULAR SEALANT AND WOUND DRESSING 审中-公开止血材料基于胶原蛋白I型和II FOR USE AS闭幕血管和作为敷料
公开(公告)号：EP1105051A1
公开(公告)日：2001-06-13
申请号：EP99943668.6
申请日：1999-08-10
申请人： FIBROGEN, INC.
CPC分类号： A61L24/102 , A61B17/00491 , A61B17/0057 , A61K38/00 , A61L15/325 , A61L24/043 , A61L24/104 , C07K14/78
摘要： Polymerized type I and/or III collagen based compositions for medical use as vascular sealants and wound dressings, and the preparation thereof, are described. Prior to polymerization, the collagen monomers are prepared recombinantly whereby chemical modifications of the collagen are not needed to form such monomers. The type I and/or III collagen compositions, which include gelatin comprised of type I and type III collagens, are useful as medical adhesives for bonding soft tissues and as sealants for a variety of medical uses. In a further aspect of the present invention, the polymerized type I and/or III collagen compositions include agents which induce wound healing or provide for additional beneficial characteristics desired in a tissue sealant or wound dressing. The compositions of the present invention are also useful in non-adhesive form.
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48.发明公开
公开(公告)号：EP3741389A1
公开(公告)日：2020-11-25
申请号：EP20176176.4
申请日：2020-05-22
申请人： Fibrogen, Inc.
IPC分类号： A61K39/395 , A61P9/00 , A61P11/00 , A61P21/00
摘要： The invention relates to methods and agents useful for treating muscular dystrophies (MDs), in particular, Duchenne muscular dystrophy (DMD). Methods and agents for treating various physiological and pathological features associated with muscular dystrophies are also provided.
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公开(公告)号：EP1487472B1
公开(公告)日：2019-06-26
申请号：EP02797195.1
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： GUENZLER-PUKALL, Volkmar , NEFF, Thomas, B. , WANG, Qingjian , AREND, Michael P. , FLIPPIN, Lee, A.
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/472 , A61K31/47 , A61K31/4738 , A61K31/496 , A61K31/4375 , A61K31/17 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K38/17 , A61K31/63 , A61K31/4745 , C07K14/505 , C07K14/47 , A61K38/00 , A61P9/10 , A61P1/16 , A61P11/00
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公开(公告)号：EP2370422B1
公开(公告)日：2019-06-05
申请号：EP09756097.3
申请日：2009-11-11
申请人： Fibrogen, Inc.
IPC分类号： C07D335/06 , C07D409/04 , A61K31/382 , A61K31/4436 , A61K31/4155 , A61P9/10
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