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公开(公告)号：EP1915994A4
公开(公告)日：2011-06-15
申请号：EP06767218
申请日：2006-06-23
申请人： SANKYO CO
发明人： NISHI TAKAHIDE , SHIMOZATO TAKAICHI , KAGARI TAKASHI , DOI HIROMI
IPC分类号： A61K31/40 , A61K31/137 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/517 , A61K45/00 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P37/02 , A61P37/06 , C07D207/335
CPC分类号： A61K31/00 , A61K31/137 , A61K31/40 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/517 , A61K45/06 , C07D207/325
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公开(公告)号：EP1932837A4
公开(公告)日：2011-05-25
申请号：EP06796445
申请日：2006-08-16
发明人： KAWAKAMI KATSUHIRO , KANAI KAZUO , HORIUCHI TAKAO , TAKESHITA HIROSHI , KOBAYASHI SYOZO , SUGIMOTO YUICHI , ACHIWA ISSEI , KUROYANAGI JUNICHI
IPC分类号： C07D263/56 , A61K31/4025 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5377 , A61P31/10 , C07D263/58 , C07D403/04 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D413/04 , C07D263/56 , C07D263/58 , C07D403/04 , C07D405/04 , C07D413/14 , C07D417/04 , C07D417/14
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公开(公告)号：EP2206727A4
公开(公告)日：2011-03-02
申请号：EP08838427
申请日：2008-10-08
发明人： HIRUMA YOSHIHARU , TSUDA EISUKE
IPC分类号： C07K16/28 , A61K31/122 , A61K31/352 , A61K31/565 , A61K31/593 , A61K31/663 , A61K38/23 , A61K39/395 , A61K45/00 , A61P19/08 , A61P19/10 , C07K16/18 , C12N5/10 , C12P21/08
CPC分类号： C07K16/2851 , A61K31/593 , A61K31/663 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2803 , C07K2317/14 , C07K2317/34 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： To provide a method of detecting abnormal bone metabolism by using a gene strongly expressed in an osteoclast; a method of screening a compound having a therapeutic and/or preventive effect on abnormal bone metabolism; and a pharmaceutical composition for treating and/or preventing abnormal bone metabolism. [Means for Resolution] Provision of a method of detecting abnormal bone metabolism by using the expression of human Siglec-15 gene as an index; a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation; and the like.
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45.发明公开SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权取代的丙烯酰胺衍生物和药物组合物含有该
公开(公告)号：EP1880720A4
公开(公告)日：2011-01-26
申请号：EP06746254
申请日：2006-05-11
发明人： AOKI KAZUMASA , SUDA KOJI , KANEKO TOSHIO , KIMURA TOMIO
IPC分类号： A61K31/166
CPC分类号： A61K31/166 , C07C237/22 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2602/08 , C07D207/327 , C07D277/30 , C07D295/13 , C07D307/54 , C07D317/54 , C07D333/16 , C07D407/04 , C07D409/04 , Y02P20/55
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公开(公告)号：EP1889618A4
公开(公告)日：2010-11-24
申请号：EP06746879
申请日：2006-05-26
发明人： NAKASHIMA RYUTARO , OGAWA JUNKO , OKUNO AKIRA
CPC分类号： A61K31/427 , A61K38/26 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2045325A4
公开(公告)日：2010-04-07
申请号：EP07791906
申请日：2007-08-03
发明人： NARA FUTOSHI , YONESU KIYOAKI , KUBOTA KAZUISHI
CPC分类号： C12Q1/485 , C12N9/1205 , C12P17/00 , G01N2500/00
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公开(公告)号：EP1614428A4
公开(公告)日：2010-01-06
申请号：EP04712221
申请日：2004-02-18
申请人： SANKYO CO
发明人： YOKOYAMA TOMIHISA , INOUE TATSUYA
IPC分类号： A61K45/06 , A61K31/4178 , A61P9/10 , A61P27/02 , A61P43/00
CPC分类号： A61K31/4178
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公开(公告)号：EP1568704A4
公开(公告)日：2009-12-02
申请号：EP03774061
申请日：2003-11-19
申请人： SANKYO CO
发明人： KOIZUMI MAKOTO , MORITA KOJI
IPC分类号： A61P31/12 , A61P35/00 , A61P43/00 , C07H21/00 , C12N15/113 , A61K31/7125 , A61K48/00
CPC分类号： C12N15/113 , C07H21/00 , C12N2310/11 , C12N2310/315 , C12N2310/319 , C12N2310/321 , C12N2310/3231 , C12N2310/3515 , Y02P20/55 , C12N2310/3521
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公开(公告)号：EP1541571A4
公开(公告)日：2008-12-03
申请号：EP03765317
申请日：2003-07-17
申请人： SANKYO CO
IPC分类号： A61P1/00 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D471/04 , A61K31/444
CPC分类号： C07D471/04
摘要： A bicyclic unsaturated tertiary amine compound which can inhibit the production of inflammatory cytokine. It is a compound represented by the following general formula (I), pharmacologically acceptable salt thereof, pharmacologically acceptable ester thereof, or pharmacologically acceptable other derivative thereof: (I) wherein A represents pyrrole or pyrazole; R1 represents optionally substituted aryl or heteroaryl; R2 represents optionally substituted heteroaryl; and R3 represents indolizine.
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