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公开(公告)号：EP3384289A1
公开(公告)日：2018-10-10
申请号：EP16823045.6
申请日：2016-12-01
发明人： GRZESIUK, Elzbieta , PIWOWARSKI, Jan , PILZYS, Tomasz , WISNIOWSKA, Iga , MARCINKOWSKI, Michal , GARBICZ, Damian , LISIK, Wojciech , KOSIERADZKI, Maciej , PACZEK, Leszek , KRASOWSKI, Pawel
IPC分类号： G01N33/561 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/561 , G01N2800/245
摘要： The invention relates to a method of protein analysis in a urine sample, including preparation of the urine sample and protein detection, wherein the step of preparation of the urine sample for analysis includes mixing the sample without centrifugation and protein detection is performed for the whole urine.
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公开(公告)号：EP2714042B1
公开(公告)日：2018-08-29
申请号：EP12735347.2
申请日：2012-05-31
IPC分类号： A61K31/485 , A61K33/06 , A61K45/06 , A61P25/04 , A61K9/16 , A61K31/135 , A61K31/137 , A61K31/19 , A61K31/194 , A61K31/197 , A61K33/14
CPC分类号： A61K33/14 , A61K9/16 , A61K9/1611 , A61K31/135 , A61K31/137 , A61K31/19 , A61K31/194 , A61K31/197 , A61K31/485 , A61K33/06 , A61K45/06 , A61P25/04 , Y10S514/951 , A61K2300/00
摘要： The disclosed analgesic pharmaceutical composition for oral administration is characterized in that it contains an opioid and a pharmaceutically admissible magnesium (II) compound, possibly along with one or more pharmaceutically admissible ancillary substances.
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公开(公告)号：EP3358355A1
公开(公告)日：2018-08-08
申请号：EP17461508.8
申请日：2017-02-04
发明人： MUCHA, Krzysztof , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , PACZEK, Leszek , KRATA, Natalia , GALA, Kamila
IPC分类号： G01N33/68 , G01N33/564
CPC分类号： G01N33/6893 , G01N33/564 , G01N2333/908 , G01N2800/347
摘要： The resent invention relates to the use of at least one of 2-Cys-PRDXs selected from a group consisting of PRDX1, PRDX2, PRDX3, PRDX4 and PRDX5 as a biomarker to diagnose, differentiate and/or assess the risk of chronic kidney disease (CDK). Present invention also relates to the method of diagnosis and the method of determining an increased risk of chronic kidney disease (CKD). Present invention also provides a kit suitable for diagnosis and differentiation of chronic kidney disease (CKD) selected from the group comprising lupus nephritis (LN), IgA nephropathy (IgAN) and autosomal-dominant polycystic kidney disease (ADPKD) in a subject.
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44.发明公开SYNERGISTIC COMBINATION OF TXNR INHIBITORS AND ASCORBATE FOR TREATMENT OF B CELL MALIGNANCIES 审中-公开TXNR抑制剂与抗坏血酸的协同处理治疗B细胞恶性肿瘤
公开(公告)号：EP3181118A1
公开(公告)日：2017-06-21
申请号：EP15461585.0
申请日：2015-12-14
IPC分类号： A61K9/00 , A61K31/375 , A61K31/66 , A61K31/7012 , A61K33/24 , A61P35/02
CPC分类号： A61K31/375 , A61K31/66 , A61K31/7012 , A61K33/24 , A61K2300/00
摘要： The present invention relates to a prooxidant synergistic combination to treat B-cell malignancies, such as B cell lymphomas, which comprises a thioredoxin reductase inhibitor, selected from a group comprising auranofin and SK053, and L- or D-ascorbate. The combination of the invention exerts synergistic cytotoxic effects towards malignant, but not normal B cells.
摘要翻译： 本发明涉及用于治疗B细胞恶性肿瘤（例如B细胞淋巴瘤）的促氧化剂协同组合，其包含选自包含金诺芬和SK053的组的硫氧还蛋白还原酶抑制剂和L-或D-抗坏血酸盐。 本发明的组合对恶性而非正常的B细胞发挥协同的细胞毒性作用。
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45.发明公开
公开(公告)号：EP3124016A1
公开(公告)日：2017-02-01
申请号：EP15460037.3
申请日：2015-07-31
发明人： Zegrocka-Stendel, Oliwia , Huszcza, Grzegorz , Pesta, Edyta , Smedra, Katarzyna , Koziak, Katarzyna
IPC分类号： A61K9/107 , A61K9/113 , A61K47/02 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/18 , A61K31/546
CPC分类号： A61K9/107 , A61K9/113 , A61K31/546 , A61K47/02 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/18
摘要： The present invention relates to the antipsoriatic emulsion composition, especially in the form of a cream, comprising an effective therapeutic dose of cefazolin, the ingredients of the oil phase and the ingredients of the water phase, characterized by that
(i) the ingredients of the oil phase include:
- liquid paraffin or white petrolatum,
- polyoxyethylene stearyl ether (21), and
- cetostearyl alcohol;
(ii) the ingredients of the oil phase include a buffer solution to maintain the pH value of the initial composition from 5 to 9, preferably in the range 6 - 8,
(iii) optionally, comprising an additional amphiphilic nonionic emulsifier, and other soluble/water miscible excipients,
wherein water content accounts for 50 to 80% by weight of the composition.摘要翻译： 本发明涉及抗牛皮癣乳剂组合物，特别是霜剂形式，其包含有效治疗剂量的头孢唑啉，油相的成分和水相的成分，其特征在于（i） 油相包括： - 液体石蜡或白凡士林， - 聚氧乙烯十八烷基醚（21）和 - 十六醇硬脂醇; （ii）油相的成分包括将初始组合物的pH值保持在5至9，优选在6-8范围内的缓冲溶液，（iii）任选地包含另外的两亲性非离子乳化剂和其它可溶的 /水混溶性赋形剂，其中水含量占组合物重量的50〜80％。
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46.发明公开Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound 有权Protoescigenin衍生物，其制造方法，使用该化合物和药物组合物包含所述化合物
公开(公告)号：EP3061765A1
公开(公告)日：2016-08-31
申请号：EP15000566.8
申请日：2015-02-27
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Grynkiewicz, Grzegorz , Gruza, Mariusz Marek , Jatczak, Kamil , Filip, Katarzyna , Cmoch, Piotr , Laszcz, Marta
CPC分类号： C07J63/008
摘要： The present invention relates to a protoescigenin derivative having pharmacological properties, process of its preparation, use of such compound as medicament especially for treating vascular disorders, as well as to a pharmaceutical composition comprising such compound.
摘要翻译： 本发明涉及一种protoescigenin衍生物具有药理学性质，其制备方法，以及利用搜索化合物作为药物的爱尤其用于治疗血管疾病，以及涉及包含寻求化合物的药物组合物。
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47.发明公开USE OF BACTERIOPHAGES 有权T4 PHAGE IN DER VERWENDUNG ZUR BEHANDLUNG VON ADENOVIRALER INFEKTION VERURSACHTEN VON HADV
公开(公告)号：EP3003333A1
公开(公告)日：2016-04-13
申请号：EP14741948.5
申请日：2014-06-03
申请人： Warszawski Uniwersytet Medyczny , Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu
发明人： JAKUBOWSKA-ZAHORSKA, Renata , PRZYBYLSKI, Maciej , BORYSOWSKI, Jan , GÓRSKI, Andrzej , WEBER-DABROWSKA, Beata
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/10132
摘要： We disclose the use of a strain of bacteriophages in the manufacturing of a preparation for improving the state of health of patients infected with adenoviruses, wherein preferably the preparation produced is used for the treatment or prevention of adenoviral infections, particularly those caused by HAdV, preferably HAdV-5.
摘要翻译： 我们公开了在制备用于改善感染腺病毒的患者的健康状况的制剂中使用噬菌体的方法，其中优选地，所产生的制剂用于治疗或预防腺病毒感染，特别是由HAdV引起的那些感染 的HAdV-5。
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48.发明授权Halogen derivatives of benzo[b]furans useful as anti-neoplastic or anti-proliferative drugs 有权苯并卤化衍生物并[b]呋喃，和它们作为抗增殖药物和antineoplastiche使用
公开(公告)号：EP2631232B1
公开(公告)日：2015-09-16
申请号：EP13150611.5
申请日：2013-01-09
发明人： Kossakowski, Jerzy , Kuran, Bozena , Kazmierczak-Baranska, Julia , Krolewska, Karolina , Nawrot, Barbara , Krawiecka, Mariola , Cieslak, Marcin
IPC分类号： C07D307/80 , C07D307/85 , A61K31/343 , A61P35/00
CPC分类号： C07D307/80 , C07D307/85
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49.发明授权NOVEL ESTERS OF (ACYLOXYMETHYL)ACRYLAMIDE, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE THIOREDOXIN - THIOREDOXIN REDUCTASE SYSTEM 有权新型酰氧基甲基）丙烯酰胺酯，含药物组合物及其作为硫氧还蛋白硫氧还蛋白REDUKTASESYSTEMS的抑制剂
公开(公告)号：EP2627628B1
公开(公告)日：2015-04-15
申请号：EP11781886.4
申请日：2011-10-16
发明人： OSTASZEWSKI, Ryszard , KLOSSOWSKI, Szymon , ZIUZIA, Izabela , SZOKALSKA, Angelika , SWIECH, Marta , GOLAB, Jakub
IPC分类号： C07C235/28
CPC分类号： C07C235/28
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