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    Recombinant therapies for infection and hyperproliferative disorders
    43.
    发明授权
    Recombinant therapies for infection and hyperproliferative disorders 失效
    Rekombinanttherapien感染和过度增生性疾病

    公开(公告)号：EP0832980B1

    公开(公告)日：2002-06-19

    申请号：EP97113730.2

    申请日：1990-01-22

    申请人： CHIRON CORPORATION

    发明人： Goldsmith, Mark A. ,  Ralston, Robert O.

    IPC分类号： C12N15/85 ,  A61K39/12 ,  C07H15/12 ,  C12N15/00 ,  C12N5/10 ,  C12N7/00 ,  A61K48/00

    CPC分类号： A61K31/70 ,  C12N15/85 ,  Y02A50/465

    摘要： The present invention provides polynucleotide constructs, e.g. recombinant viral vectors, for treating a host cell for a hyperproliferative disorder or infection by an infectious agent, said infection or hyperproliferative disorder being characterised by a human disease-associated trans-acting regulatory factor capable of regulating expression of genes. In particular, the present invention provides such constructs comprising: (i) at least two tandem copies of a cis-acting regulatory sequence which are controllable by said trans-acting regulatory factor; and (ii) an effector gene under the control of said cis-acting regulatory sequence the expression of which renders said cell susceptible to protection or destruction, said effector gene encoding a gene product which is capable of converting a prodrug into its active drug form.

    METHODS OF POPULATING DATA STUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS
    48.
    发明公开
    METHODS OF POPULATING DATA STUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS 审中-公开
    方法填入数据结构进化模拟

    公开(公告)号：EP1151409A1

    公开(公告)日：2001-11-07

    申请号：EP00902439.9

    申请日：2000-01-18

    申请人： Maxygen, Inc.

    发明人： SELIFONOV, Sergey A. ,  STEMMER, Willem, P., C.

    IPC分类号： G06F19/00

    CPC分类号： C12N15/1031 ,  B01J2219/00689

    摘要： In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; addding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.