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公开(公告)号：EP4382100A1
公开(公告)日：2024-06-12
申请号：EP22851497.2
申请日：2022-08-02
发明人： BARREIRO, Gabriela , SANT´ANA, Danilo Pereira De , GAMBA, Luis Eduardo Reina , FRAGA, Carlos Alberto Manssour , BARREIRO, Eliezer Jesus De Lacerda , LIMA, Lídia Moreira
IPC分类号： A61K31/175 , A61K31/4965 , A61P25/02 , A61P29/00
CPC分类号： A61P29/00 , A61K31/4965 , A61P25/02 , A61K31/175
摘要： The present invention relates to N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors. More specifically, the present invention relates to N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention is applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.
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42.发明公开NON-AGGLOMERATING BIOCONJUGATES OF AMYLIN-MIMETIC COMPOUNDS AND POLYETHYLENEGLYCOL 审中-公开NICHTAGGLOMERIERENDE BIOKONJUGATE VON AMYLINMIMETISCHEN VERBINDUNGEN UND POLYETHYLINGLYKOL
公开(公告)号：EP3007721A1
公开(公告)日：2016-04-20
申请号：EP14810520.8
申请日：2014-06-13
发明人： TRAMBAIOLI DA ROCHA E LIMA, Luis Mauricio , GUERREIRO ROSADO, Luiz Henrique , AVILA NETTO GUTERRES, Mariana Fernandes de , MELO VIEIRA GONÇALVES FERREIRA, Bruno
IPC分类号： A61K38/22 , A61K47/48 , C07K14/575 , C07K1/113 , A61P3/10 , A61P5/48 , A61P5/50 , A61P9/10 , A61P25/28
摘要： The present invention generally concerns new non-agglomerating bioconjugates of amylin-mimetic compounds with polyethylene glycol, and their use mainly in the treatment of diseases associated with extracellular amyloid deposition or accumulation that contributes to the dysfunction or failure of systemic organs such as the pancreas.
摘要翻译： 本发明一般涉及胰岛淀粉样多肽模拟化合物与聚乙二醇的新的非附聚生物缀合物，其主要用于治疗与细胞外淀粉样蛋白沉积或积累相关的疾病，其有助于全身器官如胰腺的功能障碍或衰竭。
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43.发明授权COMPOSITION COMPRISING FUCOSE MANNOSE LIGAND (FML) AND SAPONIN FOR PREPARATION OF LEISHMANIASIS TRANSMISSION BLOCKING VACCINES IN HUMANS AND ANIMALS 有权岩藻糖甘露糖配体（FML）和皂苷素抑制TRANSFERRING利什曼病在人类和动物组成
公开(公告)号：EP1893640B1
公开(公告)日：2015-04-01
申请号：EP06721644.0
申请日：2006-05-03
IPC分类号： C07K14/435 , C07K4/12 , A61P33/00
CPC分类号： A61K39/008 , A61K2039/55577 , Y02A50/41
摘要： The invention relates to a composition comprising Leishmania promastigotes or Leishmania amastigotes fractions or sub-fractions called "Fucose Mannose Ligand" (FML) and saponin. The invention also comprises the use of the composition for preparation of a blocking vaccine impeding Leishmaniasis transmission in humans or animals.
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44.发明公开
公开(公告)号：EP2453912A1
公开(公告)日：2012-05-23
申请号：EP10799300.8
申请日：2010-02-03
IPC分类号： A61K39/00
CPC分类号： A61K45/06 , A61K31/706 , A61K39/008 , A61K2039/55577 , A61K2300/00
摘要： Process and immune chemotherapeutic/pharmaceutical composition for treatment of canine and human Leishmaniasis comprising a vaccine containing the FML antigen (Fucose Mannose-Ligand) and saponin adjuvant, used in association with chemotherapeutic agents, showing healing property, leaving the dogs previously infected, in the condition of sterile cure of visceral and tegumentary leishmaniasis, characterized by absence of parasites and the overall absence of Leishmania DNA, aiming to stave off the spread of the parasite which causes canine visceral leishmaniasis in dog to the insect transmitter, thus to other dogs and humans. The invention also comprises also the use of the aforementioned composition to produce formulations designed to treat canine visceral leishmaniasis and visceral and murine tegumentary leishmaniasis, human and canine, as well as a kit comprising immune chemotherapeutic agents to treat the same diseases.
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45.发明公开NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION CONTAINING THE NEW COMPOUNDS OF THE PTEROCARPANQUINONE FAMILY, USES AND THERAPEUTIC METHOD 审中-公开用于生产PTEROCARPANCHINONFAMILIE药物组合物，应用和治疗方法的新化合物PTEROCARPANCHINONFAMILIE，工艺的新化合物
公开(公告)号：EP2366684A1
公开(公告)日：2011-09-21
申请号：EP09825667.0
申请日：2009-11-05
发明人： DA SILVA, Alcides José Monteiro , RUMJANEK, Vivian Mary Barral Dold , BERGMANN, Bartira Rossi , DOS SANTOS, Eduardo Salustiano Jesus , COSTA, Paulo Roberto, Ribeiro , NETTO, Chaquip Daher , LIMA, Wallace, Pacienza , DOS SANTOS, Eduardo Caio Torres , CAVALCANTE, Moisés Clemente, Marinho , SEABRA, Sérgio, Henrique , RICA, Sérgio Henrique
CPC分类号： C07D493/04 , C07B2200/07
摘要： This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-α in human and nonhuman mammals.
摘要翻译： 本发明属于化学制药领域。 在式（I）gemäß呈现给本发明pterocarpanquinone家族的新化合物能够通过还原烷基化生成细胞内物质被激活。 它提出对哺乳动物特别是人类和非人类细胞的选择性细胞毒性效应并不断分裂，可用于治疗与不期望的细胞增殖的现象的疾病和功能障碍有用。 搜索化合物因此为与在人和非人哺乳动物高水平TNF±的疾病或功能障碍治疗有效。
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46.发明公开
公开(公告)号：EP2170096A2
公开(公告)日：2010-04-07
申请号：EP08757077.6
申请日：2008-06-30
发明人： VERMELHO, Alane, Beatriz , VASQUEZVILLA, Ana Lúcia , DE ALMEIDA, Ana Maria, Mazotto , DE SOUZA DIAS, Edilma, Paraguai , DOS SANTOS, Elisabete, Pereira
摘要： This present invention provides a process for keratin hydrolysis by means of microbiological and/or enzymatic processes. In particular, the keratin is derived from feathers of animals, such as chicken and are submmited to hydrolysis by a strain of Bacillus sp. The hydrolysates have molecular weight lower than 500 Da, which makes them ideal for cosmetic applications, particularly for applications in compositions for treatment of hair fiber re-building.
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47.发明公开COMPOUND WITH ANESTHETICS ACTIVITY, METHODS FOR ITS PRODUCTION AN PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开带有麻醉性，方法ITS和药物组合物含CONNECTION
公开(公告)号：EP2167475A2
公开(公告)日：2010-03-31
申请号：EP08748070.3
申请日：2008-05-05
发明人： DA ROCHA PITTA, Ivan , DO CARMO ALVES DE LIMA, Maria , GONÇALVES DA SILVA, Teresinha , ZAPATA SUDO, Gisele , LINS GALDINO, Suely , TAKASHI SUDO, Roberto
IPC分类号： C07D233/72
CPC分类号： C07D233/74
摘要： The present invention is related to a new series of chemical compounds, namely 3-benzyl-imidazolidine-2,4-dione substituted in the position 2 and/or 6 of benzyl ring by halogens as presented to the molecule named LPSF-PT-31, GIRSUPAN and its therapeutic use as drug with analgesic, sedative and adjuvant of anesthetics activities. The invention is also related to a process for production of said compounds as well as pharmaceutical compositions comprising them.
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48.发明公开METHOD FOR BUILDING SPONTANEOUS VIRTUAL COMMUNITIES BASED ON COMMON INTERESTS USING WIRELESS EQUIPMENTS 审中-公开方法用于构建虚拟自发意思属性，根据使用无线设备的共同利益
公开(公告)号：EP2052474A2
公开(公告)日：2009-04-29
申请号：EP07784940.4
申请日：2007-08-17
摘要： The present invention relates to a method for establishing a communication network that connects a group or community of users (102) using wireless equipments (101 ) according to their defined interests. These equipments (101 ) are preferentially portable, low cost, and user- friendly, where each equipment (101 ) must be configurable using its user's profile, which contains a small amount of the user's personal data, namely the miniprofile. The method uses a collection of such miniprofiles to transparently set a communication network among the associate users to establish a virtual community. In addition, each profile will contain further information on user's interests, which the method will propagate across the communication network to the established virtual community in a way that their members will be able to form groups (102) based on common interests while allowing for interaction among their members. The user profile can be set identifiable or anonymous, may or not be shareable in relation to the other members of a group (102). The method is distributed, and supports spontaneous and volatile communication networks, preferentially.
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公开(公告)号：EP1192260B1
公开(公告)日：2008-12-31
申请号：EP00945887.8
申请日：2000-07-05
CPC分类号： C12N9/1205 , C07K14/415 , C12N15/8261 , C12N15/8285 , C12N15/8289 , Y02A40/146 , Y02A40/164
摘要： The present invention relates to at least partially purified protein, capable of modulating the DNA replication in plants, muteins thereof, DNA coding therefor and to a method to confer to one or more plant cells the capacity to provide such a protein or mutein. The invention also relates to plants, comprising the said DNA and the progeny thereof.
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50.发明公开
公开(公告)号：EP1812027A2
公开(公告)日：2007-08-01
申请号：EP05799977.3
申请日：2005-10-21
申请人： Universidade Federal Do Rio De Janeiro - UFRJ , Fundacao Universidade de Brasilia - UNB , Uniao Brasiliense de Educacao e Cultura- UBEC
发明人： SOARES ROMEIRO, Luis Antõnio , CÃNDIDA DA SILVA, Viviane , MÁRCIA MURTA, María , GOUVAN CAVALCANTE, Magalhães , LIMA LOGRADO, Lucio Paulo , DOS SANTOS, Maria Lucilia , SABIONI RESCK, Inês , DE ARAÜJO MOURA, Emeli , DELLAMORA-ORTIZ, Gisela Maria , DA COSTA LEITÃO, Álvaro Augusto , SANTOS DA SILVA, Célia , FARIA DE FREITAS, Zaida Maria , PEREIRA DOS SANTOS, Elisabete
IPC分类号： A61K36/22
摘要： The molecules capable of absorbing ultraviolet radiation from the cashew nut shell liquid changes are the object of the present invention; it is also described the compositions responsible for protecting the surfaces and chemical processes for the referred molecules production.
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