公开(公告)号：EP3296386A1

公开(公告)日：2018-03-21

申请号：EP16792183.2

申请日：2016-05-11

申请人： Xiamen University ,  Xiamen Innodx Biotech Co., Ltd

发明人： GE, Shengxiang ,  ZHANG, Shiyin ,  XU, Feihai ,  WANG, Jin ,  LI, Jinjie ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C12M1/24 ,  C12M1/38

摘要： Disclosed are a reaction tube for nucleic acid amplification capable of controlling a liquid circulation path, a reaction apparatus for nucleic acid amplification comprising the reaction tube, and a method for amplifying nucleic acid comprising a step of using the reaction tube. Also disclosed are a kit comprising the reaction tube, and use of the reaction tube in preparation of a kit.

摘要翻译： 本发明公开了一种能够控制液体循环路径的用于核酸扩增的反应管，包括该反应管的用于核酸扩增的反应装置以及一种用于扩增核酸的方法，该方法包括使用该反应管的步骤。 还公开了包含反应管的试剂盒以及使用反应管制备试剂盒。

公开(公告)号：EP3258265A1

公开(公告)日：2017-12-20

申请号：EP16748586.1

申请日：2016-01-26

申请人： Xiamen University

发明人： GE, Shengxiang ,  LI, Jinjie ,  HUANG, Xi ,  LI, Tingdong ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： G01N33/53 ,  G01N33/569 ,  G01N33/543

CPC分类号： G01N33/56983 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/56994 ,  G01N2333/045 ,  G01N2469/20 ,  G01N2800/50 ,  G01N2800/52

摘要： The invention belongs to the fields of medicine and immunology, particularly, the field of immunological diagnosis. In particular, the invention discloses a method for assessing whether a subject is at risk of developing human cytomegalovirus (HCMV) active infection and a kit therefor. The method comprises the steps of: (1) determining the level of an antibody against a HCMV protein in a body fluid sample from the subject; and (2) comparing the level with a predetermined reference value, wherein if the level is below the predetermined reference value, the subject is determined to be at risk of developing HCMV active infection. In addition, the invention also discloses a method for screening a candidate drug which is capable of improving the ability of a subject to resist human cytomegalovirus (HCMV) active infection, and a kit therefor.

摘要翻译： 本发明属于医学和免疫学领域，特别是免疫学诊断领域。 特别地，本发明公开了评估受试者是否有发生人巨细胞病毒（HCMV）活性感染风险的方法及其试剂盒。 该方法包括以下步骤：（1）确定来自受试者的体液样品中针对HCMV蛋白的抗体水平; 和（2）将该水平与预定参考值进行比较，其中如果该水平低于预定参考值，则确定该受试者处于发生HCMV活动性感染的风险中。 此外，本发明还公开了用于筛选能够改善受试者抵抗人巨细胞病毒（HCMV）活性感染的能力的候选药物的方法及其试剂盒。

公开(公告)号：EP2589604B1

公开(公告)日：2016-10-05

申请号：EP11800199.9

申请日：2011-07-01

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  MO, Xiaobing ,  WEI, Minxi ,  PAN, Huirong ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/70 ,  C12N1/21 ,  A61K39/12 ,  A61P31/20

CPC分类号： C07K14/025 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/585 ,  C07K14/005 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20051 ,  C12P21/02

公开(公告)号：EP2154147B1

公开(公告)日：2015-10-07

申请号：EP08748431.7

申请日：2008-04-29

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： GU, Ying ,  LI, Shaowei ,  WEI, Minxi ,  XIAN, Yangling ,  LUO, Wenxin ,  XIA, Ningshao

IPC分类号： C12N7/02 ,  C07K14/025 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

公开(公告)号：EP2460878A9

公开(公告)日：2012-08-22

申请号：EP10803804.3

申请日：2010-07-27

申请人： New Jersey Medical School ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： ZHU, Hua ,  LI, Yimin ,  XIA, Ningshao ,  CHENG, Tong ,  YE, Xiangzhong

IPC分类号： C12N7/00 ,  C12N7/04 ,  C12N7/01 ,  A61K39/25 ,  A61P31/22 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/25 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

摘要翻译： 提供了ORF7缺陷型水痘病毒，包含该病毒的疫苗及其用途，以及该病毒的生产方法。

公开(公告)号：EP2147926A1

公开(公告)日：2010-01-27

申请号：EP08748432.5

申请日：2008-04-29

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： Li, Shaowei ,  SHEN, Wentong ,  LI, Zhongyi ,  XIE, Minghui ,  PAN, Huirong ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/37 ,  C12N15/63 ,  A61K39/12 ,  C12N7/04 ,  A61P35/00

CPC分类号： A61K39/12 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/20011 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034

摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 18, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of cervical caner.

摘要翻译： 本发明涉及人乳头瘤病毒18型的截短的L1蛋白，由蛋白组成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及在预防宫颈癌中使用该疫苗。

公开(公告)号：EP4434626A1

公开(公告)日：2024-09-25

申请号：EP22894720.6

申请日：2022-11-11

申请人： Xiamen University ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen Innodx Biotech Co., Ltd

发明人： ZHANG, Dongxu ,  GAO, Runxin ,  HUANG, Shaolei ,  HUANG, Yulin ,  LIU, Guoqiang ,  YANG, Jiayu ,  ZENG, Juntian ,  SONG, Liuwei ,  GE, Shengxiang ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： B01L3/00 ,  B01J19/00

CPC分类号： B01L3/00 ,  B01J19/00

摘要： The present disclosure relates to a microfluidic chip and a microfluidic chip detection system. The microfluidic chip including: a storage member provided with a groove therein, at least two storage chambers being disposed around the groove; a base disposed at one end of the storage member away from the groove, a reaction chamber being disposed on the base; and a valve disposed in the groove, the valve being configured to operatively communicate any one of the at least two storage chambers with the reaction chamber. The present disclosure can lead the solution in any storage chamber to the reaction chamber or lead the solution in the reaction chamber to any storage chamber by operating the valve, so that the solution transfer is realized, the structure is simple and compact, the length of the flow channels can be greatly shortened, and the detection efficiency is improved.

公开(公告)号：EP4378951A1

公开(公告)日：2024-06-05

申请号：EP22848410.1

申请日：2022-07-21

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： CHENG, Tong ,  ZHU, Rui ,  YANG, Hongwei ,  XU, Longfa ,  LIN, Yu ,  ZHOU, Zhenhong ,  YE, Xiangzhong ,  XIA, Ningshao

IPC分类号： C07K7/08 ,  C12N15/00 ,  A61K39/125 ,  A61K48/00

CPC分类号： C12N15/00 ,  C07K7/08 ,  A61K48/00 ,  A61K39/125

摘要： The present invention belongs to the field of immunobiology, and relates to an epitope polypeptide, such as a general affinity epitope polypeptide of human rhinovirus, and the use thereof. The present invention further relates to an antibody capable of binding to the epitope polypeptide and the use thereof. The present invention further relates to the use of the affinity epitope polypeptide or the antibody in the preparation of drugs or in methods for treating and/or preventing and/or diagnosing human rhinovirus and/or identifying a titer of human rhinovirus and/or identifying a titer of a neutralizing antibody of human rhinovirus. The affinity epitope polypeptide and antibody can be used in drugs or methods for treating and/or preventing and/or diagnosing human rhinovirus and/or identifying a titer of human rhinovirus and/or identifying a titer of a neutralizing antibody of human rhinovirus.

公开(公告)号：EP4113121A1

公开(公告)日：2023-01-04

申请号：EP21760161.6

申请日：2021-01-18

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： LI, Tingdong ,  SHI, Qiaoyun ,  REN, Jinkai ,  GE, Shengxiang ,  HONG, Congming ,  ZHANG, Xiaolei ,  WANG, Dong ,  ZHOU, Guoliang ,  YUAN, Quan ,  WU, Xiaowei ,  WANG, Xuan ,  WU, Yangtao ,  PAN, Haifeng ,  QI, Yuting ,  JIA, Xuerong ,  ZHOU, Lizhi ,  HOU, Wangheng ,  QIAO, Shan ,  LI, Shaowei ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： G01N33/68 ,  G01N33/569 ,  G01N33/558 ,  C12N15/867 ,  C12N15/65 ,  C07K14/165

摘要： Provided are a method for assaying a specific IgM antibody and a total antibody for the 2019 novel coronavirus (2019-nCOV), a method for determining whether subjects are infected with 2019-nCOV, and a virus antigen and a kit for carrying out the above-mentioned detection.

公开(公告)号：EP3812395A1

公开(公告)日：2021-04-28

申请号：EP19815298.5

申请日：2019-06-04

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  SONG, Shuo ,  HE, Maozhou ,  SHI, Jingjie ,  GU, Ying ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/11 ,  A61K39/12 ,  A61P35/00

摘要： The present invention relates to a mutated HPV18 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (for example, HPV18 and HPV45, or HPV18, HPV45 and HPV59), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.