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公开(公告)号：EP3812771A1
公开(公告)日：2021-04-28
申请号：EP19823488.2
申请日：2019-05-29
发明人： CHEN, Zimin , XIONG, Junhui , XU, Weiling , WENG, Zuxing , WANG, Long , ZHENG, Xiaohong , SUN, Xudong , GE, Shengxiang
IPC分类号： G01N33/68
摘要： The invention provides a kit for full-range detection of C-reactive protein based on chemiluminescence immunoassay and a method for full-range detection of C-reactive protein. The kit comprises an R1 reagent, an M reagent, an R2 reagent, a pre-excitation solution and an excitation solution. The R1 reagent, that is a sample treatment solution, is a 0.5M citric acid solution (pH 3.0-3.5, which is adjusted by disodium hydrogen phosphate dodecahydrate). The present invention also provides a kit for full-range detection of C-reactive protein, which comprises a flat-bottomed plate-type chemiluminescence plate coated with a first antibody, a sample treatment solution, a second antibody labeled with horseradish peroxidase (HRP) or alkaline phosphatase (AP), a color developing solution. The invention also provides a method for full-range detection of C-reactive protein using the kit. Both the first antibody and the second antibody are monoclonal antibodies that can specifically react with C-reactive protein.
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公开(公告)号：EP3885363A1
公开(公告)日：2021-09-29
申请号：EP19888178.1
申请日：2019-11-06
发明人： XIONG, Junhui , CHEN, Zimin , XU, Weiling , WANG, Long , KE, Qishen , LI, Lihua , SONG, Liuwei , SUN, Xudong , GE, Shengxiang
IPC分类号： C07K16/26 , C12N5/20 , G01N33/74 , G01N33/577
摘要： The present invention belongs to the field of biomedical laboratory science, and provides a specific antibody for AMH and uses thereof.
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公开(公告)号：EP4434626A1
公开(公告)日：2024-09-25
申请号：EP22894720.6
申请日：2022-11-11
申请人： Xiamen University , Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. , Xiamen Innodx Biotech Co., Ltd
发明人： ZHANG, Dongxu , GAO, Runxin , HUANG, Shaolei , HUANG, Yulin , LIU, Guoqiang , YANG, Jiayu , ZENG, Juntian , SONG, Liuwei , GE, Shengxiang , ZHANG, Jun , XIA, Ningshao
摘要： The present disclosure relates to a microfluidic chip and a microfluidic chip detection system. The microfluidic chip including: a storage member provided with a groove therein, at least two storage chambers being disposed around the groove; a base disposed at one end of the storage member away from the groove, a reaction chamber being disposed on the base; and a valve disposed in the groove, the valve being configured to operatively communicate any one of the at least two storage chambers with the reaction chamber. The present disclosure can lead the solution in any storage chamber to the reaction chamber or lead the solution in the reaction chamber to any storage chamber by operating the valve, so that the solution transfer is realized, the structure is simple and compact, the length of the flow channels can be greatly shortened, and the detection efficiency is improved.
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公开(公告)号：EP4092050A1
公开(公告)日：2022-11-23
申请号：EP21741247.7
申请日：2021-01-18
发明人： CHEN, Zimin , XIONG, Junhui , LIU, Jiaqi , WANG, Shaojuan , GE, Shengxiang , YUAN, Quan , SONG, Liuwei , SUN, Xudong
IPC分类号： C07K16/18
摘要： In the field of Hepatitis B virus (HBV) detection, disclosed are a method for detecting HBcAg by means of using a double antibody sandwich method, and an antibody and kit for detecting HBcAg; also included is a monoclonal antibody that can be used in the immunological detection of HBcAg in a tissue or cell sample.
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公开(公告)号：EP4086274A1
公开(公告)日：2022-11-09
申请号：EP20909593.4
申请日：2020-12-25
发明人： LI, Tingdong , GE, Shengxiang , GUO, Xiaoyi , HONG, Congming , SONG, Liuwei , WEN, Shunhua , TANG, Jiabao , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/435 , C07K14/00 , G01N33/68 , G01N33/574 , G01N33/569
摘要： Provided are a method for diagnosing nasopharyngeal carcinoma on the basis of the anti-EB virus (EBV) antibody level and a kit used for the method. Also provided are a polypeptide encoded by a BNLF2b gene in EB virus used for the above-mentioned diagnosis and the use thereof for diagnosing nasopharyngeal carcinoma.
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公开(公告)号：EP3296386B1
公开(公告)日：2020-05-06
申请号：EP16792183.2
申请日：2016-05-11
发明人： GE, Shengxiang , ZHANG, Shiyin , XU, Feihai , WANG, Jin , LI, Jinjie , ZHANG, Jun , XIA, Ningshao
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7.发明公开NUCLEIC ACID AMPLIFICATION REACTION TUBE CAPABLE OF CONTROLLING LIQUID CIRCULATION PATH 审中-公开核酸扩增反应管可以控制液体循环路径
公开(公告)号：EP3296386A1
公开(公告)日：2018-03-21
申请号：EP16792183.2
申请日：2016-05-11
发明人： GE, Shengxiang , ZHANG, Shiyin , XU, Feihai , WANG, Jin , LI, Jinjie , ZHANG, Jun , XIA, Ningshao
摘要： Disclosed are a reaction tube for nucleic acid amplification capable of controlling a liquid circulation path, a reaction apparatus for nucleic acid amplification comprising the reaction tube, and a method for amplifying nucleic acid comprising a step of using the reaction tube. Also disclosed are a kit comprising the reaction tube, and use of the reaction tube in preparation of a kit.
摘要翻译： 本发明公开了一种能够控制液体循环路径的用于核酸扩增的反应管，包括该反应管的用于核酸扩增的反应装置以及一种用于扩增核酸的方法，该方法包括使用该反应管的步骤。 还公开了包含反应管的试剂盒以及使用反应管制备试剂盒。
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公开(公告)号：EP3299384A1
公开(公告)日：2018-03-28
申请号：EP16795912.1
申请日：2016-05-20
申请人： Xiamen University
发明人： GE, Shengxiang , LI, Tingdong , JIA, Lianzhi , LI, Yijian , XUE, Miaoge , ZENG, Yuanjun , ZHANG, Jun , XIA, Ningshao
CPC分类号： C07K14/005 , A61K39/12 , A61K39/15 , A61K2039/552 , A61K2039/55505 , A61K2039/575 , A61P1/00 , A61P1/12 , A61P29/00 , A61P31/14 , C12N7/00 , C12N2720/12322 , C12N2720/12334 , C12N2720/12351
摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.
摘要翻译： 本发明涉及截短的轮状病毒VP4蛋白，编码它的序列，其制备方法，以及包含该蛋白的药物组合物和疫苗，其中该蛋白，该药物组合物和疫苗可用于预防，缓解 或治疗轮状病毒感染和轮状病毒感染引起的疾病，如轮状病毒胃肠炎和腹泻。 本发明进一步涉及该蛋白质在制备用于预防，减轻或治疗轮状病毒感染和由轮状病毒感染引起的疾病（例如轮状病毒胃肠炎和腹泻）的药物组合物或疫苗中的用途。
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公开(公告)号：EP4086275A1
公开(公告)日：2022-11-09
申请号：EP20910955.2
申请日：2020-11-09
发明人： GE, Shengxiang , YU, Siyuan , YANG, Han , PAN, Haifeng , REN, Shuling , LI, Tingdong , GUO, Qingshun , XIONG, Junhui , ZHANG, Jun , XIA, Ningshao
摘要： A multimerization delivery system that can be used to deliver a cargo molecule intracellularly. The multimerization delivery system can achieve high-efficiency endocytosis of a cargo molecule and high-efficiency release thereof from an endocytic vesicle, significantly improving the cytoplasmic delivery efficiency of the cargo molecule. Once the cargo molecule is available in the cytoplasm, the cargo molecule can play any role related thereto. The multimerization delivery system provides an effective means for affecting the biological mechanisms and pathways of cells, and can be used in various fields such as research, treatment, and diagnosis.
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10.发明公开ANTI-HBC QUANTITATIVE DETECTION METHOD AND USES THEREOF IN MONITORING AND CONTROLLING DISEASE PROGRESSION OF CHRONIC HEPATITIS B PATIENT AND IN PREDICTING THERAPEUTIC EFFECT 有权对于定量检测抗HBC方法及其用途的监视和控制病程的慢性乙肝患者，并在治疗效果的预测
公开(公告)号：EP2805729A1
公开(公告)日：2014-11-26
申请号：EP13738450.9
申请日：2013-01-17
发明人： YUAN, Quan , SONG, Liuwei , ZHOU, Wenbin , WENG, Zuxing , XU, Feihai , GE, Shengxiang , ZHANG, Jun , XIA, Ningshao
CPC分类号： G01N33/56983 , G01N33/5762 , G01N2333/02 , G01N2469/20 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to a method for quantitative detection of anti-HBc and its use in monitoring disease progression of chronic hepatitis B patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis B core protein (Anti-HBc), it is able to monitor disease progression of chronic hepatitis B patients, effectively predict therapeutic effects in chronic hepatitis B patients who accept a therapy against hepatitis B virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analogue anti-HBV drug), and thus guide the patients to reasonably choose drugs.
摘要翻译： 本发明涉及用于抗-HBc的定量检测及其在监测慢性乙型肝炎患者的疾病进展和预测治疗效果的使用的方法。 通过对乙型肝炎核心蛋白（抗-HBc）抗体的定量检测，它能够监测慢性乙型肝炎患者的疾病进展，有效地预测谁接受抗乙肝病毒治疗（尤其是慢性乙肝患者的治疗效果，一 治疗基于干扰素和基于核苷/核苷酸类似物的抗HBV药物治疗），因而指导患者合理选择药物。
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