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公开(公告)号：EP2044051A1
公开(公告)日：2009-04-08
申请号：EP07786791.9
申请日：2007-06-21
申请人： BIOVITRUM AB (publ)
发明人： JENMALM JENSEN, Annika , RINGOM, Rune , MEDINA, Carmen , SHILVOCK, John , WIIK, Marie , KOOLMEISTER, Tobias , ANGBRANT, Johan , SUTIN, Lori , HENRIKSSON, Martin , SANDVALL, Teresa , JOHANSSON, Lars , NILSSON, Björn
IPC分类号： C07D401/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04
CPC分类号： C07D401/12 , C07D401/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04
摘要： The present invention relates to compounds of the general formula (I) wherein X, Y, Z, A, Ar, R1, R2, R3, and R4 are as defined herein, which compounds are inhibitors of MNK2 and MNK1. The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds, and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of disorders related to undesired activity of MNK1 and/or MNK2 kinases.
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公开(公告)号：EP1549950B1
公开(公告)日：2009-02-11
申请号：EP03761006.0
申请日：2003-06-25
申请人： Biovitrum AB (publ)
发明人： KATZ, Abram , WESTERBLAD, Håkan
CPC分类号： G01N33/66 , G01N33/6893 , G01N2500/10 , G01N2500/20
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公开(公告)号：EP3601317A1
公开(公告)日：2020-02-05
申请号：EP18716200.3
申请日：2018-04-03
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公开(公告)号：EP2817329B1
公开(公告)日：2019-01-02
申请号：EP13752233.0
申请日：2013-02-19
发明人： BERGHARD, Charlotta , BERGLUND, Magnus , STRÖMBERG, Patrik , LINDBORG, Malin , GUNNERIUSSON, Elin , FELDWISCH, Joachim
IPC分类号： C07K14/00 , A61K38/00 , A61K38/16 , C07K14/195 , C07K14/315 , C07K14/47
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公开(公告)号：EP3356542A1
公开(公告)日：2018-08-08
申请号：EP16775701.2
申请日：2016-09-30
CPC分类号： C12N9/14 , A61K38/00 , C12N9/16 , C12N9/2402 , C12Y301/06013 , C12Y302/01076 , C12Y310/01001
摘要： Disclosed herein are a modified lysosomal protein, methods for preparing a modified lysosomal protein and therapeutic use of such a modified protein. Further disclosed herein is a method of treating a mammal afflicted with a lysosomal storage disease. In particular, the present disclosure relates to a method of preparing a modified lysosomal protein, said method comprising reacting a glycosylated lysosomal protein with an alkali metal periodate and reacting said lysosomal protein with an alkali metal borohydride for a time period of no more than 2 h, thereby modifying glycan moieties of the lysosomal protein and reducing the activity of the lysosomal protein with respect to glycan recognition receptors.
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46.发明公开A METHOD AND DEVICE FOR THE SERIAL EJECTION OF TWO FLUIDS COMPRISING A SPACER 审中-公开VERFAHREN UND VORRICHTUNGFÜRDEN SERIELLEN AUSSTOSS ZWEIERFLÜSSIGKEITENMIT EINEMDISTANZSTÜCK
公开(公告)号：EP2211948A4
公开(公告)日：2017-10-04
申请号：EP08852233
申请日：2008-11-21
发明人： FRANSSON JONAS , HJERTMAN BIRGER
CPC分类号： A61M5/284 , A61M5/31501 , A61M5/31596 , A61M2005/1787 , A61M2005/3132
摘要： A device for the serial ejection of at least two fluid components comprises a spacer (19) providing at least two states, i) a first state allowing a front piston (7) to be displaced forwards by action on a rear piston (17) while a fluid volume is retained in a rear chamber (5) and ii) a second state allowing the rear chamber to volumetrically shrink while fluid is transferred past (or through) the front piston thereby enabling the use of a liquid, initially provided in only the rear chamber, for the dual purposes of mixing and rinsing.
摘要翻译： 用于至少两个流体部件的串行排出的装置包括提供至少两个状态的间隔件（19），i）允许前活塞（7）通过作用在后活塞（17）上向前移位的第一状态，同时 流体容积保持在后腔室（5）中，并且ii）第二状态允许后腔室体积收缩，同时流体通过（或通过）前活塞传递，从而能够使用液体，最初仅提供在 后室，用于混合和冲洗的双重目的。
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公开(公告)号：EP2672985B1
公开(公告)日：2016-04-27
申请号：EP12744410.7
申请日：2012-02-09
CPC分类号： A61K38/2006 , A61K9/0019 , A61K9/10 , A61K38/00 , A61K38/1793 , A61K47/02 , A61K47/183 , A61K47/26 , C07K14/545 , C07K14/7155
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公开(公告)号：EP2817329A1
公开(公告)日：2014-12-31
申请号：EP13752233.0
申请日：2013-02-19
发明人： BERGHARD, Charlotta , BERGLUND, Magnus , STRÖMBERG, Patrik , LINDBORG, Malin , GUNNERIUSSON, Elin , FELDWISCH, Joachim
CPC分类号： A61K38/164 , A61K38/00 , A61K38/16 , A61K47/64 , A61K47/68 , A61K47/6801 , C07K14/00 , C07K14/195 , C07K14/315 , C07K14/47
摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from i) EX2X3X4A X6X7EID X11LPNL X16X17X18QW X21AFIX25X26LX28D, and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatments.
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公开(公告)号：EP2710126A4
公开(公告)日：2014-11-26
申请号：EP12785836
申请日：2012-05-15
发明人： STRÖMQUIST THOMAS , WOOD SUSANNE
CPC分类号： C12N9/20 , B01D15/327 , B01D15/363
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公开(公告)号：EP2672985A4
公开(公告)日：2014-07-30
申请号：EP12744410
申请日：2012-02-09
CPC分类号： A61K38/2006 , A61K9/0019 , A61K9/10 , A61K38/00 , A61K38/1793 , A61K47/02 , A61K47/183 , A61K47/26 , C07K14/545 , C07K14/7155
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