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公开(公告)号：EP1855753A2
公开(公告)日：2007-11-21
申请号：EP06734996.9
申请日：2006-02-13
CPC分类号： A61M25/0662 , A61M25/0054 , A61M25/0138 , A61M25/0141 , A61M25/104 , A61M2025/0025 , A61M2025/0063 , A61M2025/0681 , A61M2025/09125
摘要： Apparatus (10) for introducing diagnostic and/or therapeutic agents and devices within a mammalian body is disclosed. One disclosed , apparatus comprises a sheath (20) having a proximate end, a distal end and a lumen extending therebetween. An articulator (30) is disposed in the lumen of the sheath. A distal portion of the sheath is detachably attached to a distal portion of the articulator at a joint. A separator capable of severing the joint is also provided.
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公开(公告)号：EP1565104A2
公开(公告)日：2005-08-24
申请号：EP03777796.8
申请日：2003-10-23
IPC分类号： A61B5/02
CPC分类号： A61B17/11 , A61B8/06 , A61B8/08 , A61B8/12 , A61B8/4472 , A61B8/488 , A61B2017/00022 , A61B2017/1107
摘要： A vascular coupler adapted to be fixed into position upon a blood vessel and there retain and position a matable sensing device. In a preferred embodiment, the vascular coupler is an anastomotic coupler and the sensing device comprises an ultrasonic Doppler probe.
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公开(公告)号：EP1494596A1
公开(公告)日：2005-01-12
申请号：EP03716732.7
申请日：2003-03-21
IPC分类号： A61B17/08
CPC分类号： A61B17/115 , A61B17/07292 , A61B17/1114 , A61B17/1155 , A61B2017/00725
摘要： A combination medical device comprising a circular stapler instrument (4) and one or more portions of preformed buttress material (16) adapted to be stably positioned upon the staple cartridge (12) and/or anvil (14) components of the stapler (4) prior or at the time of use. Positioned buttress material(s) (16) are delivered to a tissue site where the circular stapler (4) is actuated to connect previously severed tissue portions. An embodiment of the invention allows tissue portions to be joined without the use of sutures. The buttress material (16) is made up of two regions, one of which serves primarily to secure the buttress material (16) to the stapler (4) prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler (4) to form anastomoses, while the remaining material secures and seals the newly connected tissue. Methods of use and preparation of the buttress material (16) are also described.
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公开(公告)号：EP1212105B1
公开(公告)日：2004-04-28
申请号：EP00960099.0
申请日：2000-09-14
CPC分类号： A61L27/3687 , A61L27/227 , A61L27/24 , A61L27/3604 , A61L27/362 , A61L27/3629 , A61L31/043 , A61L31/044
摘要： A non-crosslinked, decellularized and purified mammalian tissue (e.g., bovine pericardium) having particular use as an implantable resorbable material. The material is treated by alkylating its primary amine groups in a manner sufficient to reduce the antigenicity of the tissue, permitting the treated tissue to be used in vivo and without crosslinking, and in turn, permitting it to be resorbable. The material can be used in surgical repair of soft tissue deficiencies for a certain period of time while the implant itself is gradually remodeled or absorbed by the host. Also provided are a method of preparing such a material as well as a method of using such a material for surgical repair.
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公开(公告)号：EP1007699A1
公开(公告)日：2000-06-14
申请号：EP98911737.9
申请日：1998-03-16
发明人： HAWLEY-NELSON, Pamela , LAN, Jianqing , SHIH, PoJen , JESSEE, Joel, A. , CICCARONE, Valentina, C. , EVANS, Krista, L. , SCHIFFERLI, Kevin, P. , GEBEYEHU, Guililat
CPC分类号： B82Y5/00 , A61K9/1272 , A61K47/54 , A61K47/543 , A61K47/645 , A61K47/6949 , A61K48/00 , A61K48/0025 , A61K48/0041 , C07K1/1077 , C07K7/06 , C07K7/08 , C07K14/005 , C12N15/87 , C12N2740/16322
摘要： The present invention provides compositions useful for transfecting eukaryotic cells comprising nucleic acid complexes with peptides, wherein the peptide is optionally covalently coupled to a nucleic acid-binding group, and cationic lipids or dendrimers as transfection agents. The invention also provides transfection compositions in which a peptide is covalently linked to the transfection agent (lipid, cationic lipid or dendrimer). Inclusion of peptides or modified-peptides in transfection compositions or covalent attachment of peptides to transfection agents results in enhanced transfection efficiency. Methods for the preparation of transfection compositions and methods of using these transfection compositions as intracellular delivery agents and extracellular targeting agents are also disclosed.
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46.发明公开
公开(公告)号：EP0991456A1
公开(公告)日：2000-04-12
申请号：EP98930494.4
申请日：1998-06-24
CPC分类号： C12N15/1006 , B01D15/1871 , B01D15/26 , B01D15/34 , G01N30/02
摘要： A device for one step purification of a desired biological molecule from a sample, wherein the device comprises a housing loaded with an adsorptive media of a known volume on top of a size exclusion media of a known volume, and a method of purifying biological molecules using the same.
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47.发明授权HIGHLY PACKED POLYCATIONIC AMMONIUM, SULFONIUM AND PHOSPHONIUM LIPIDS 失效DICHTGEPACKTE POLYKATIONISCHE AMMONIUM，SULFONIUM UND PHOSPHONIUM LIPIDE
公开(公告)号：EP0741689B1
公开(公告)日：2000-04-05
申请号：EP95905957.7
申请日：1994-12-14
IPC分类号： C07C211/63 , A61K9/127 , C12N15/87 , C12N15/88 , C07C233/36 , C07C217/40 , C07C381/12 , C07F9/54
CPC分类号： C12N15/87 , A61K9/1272 , C07C211/63 , C07C217/40 , C07C233/36 , C07C381/12 , C07F9/5449 , C07F9/5463 , Y10S435/829
摘要： The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
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公开(公告)号：EP0986635A1
公开(公告)日：2000-03-22
申请号：EP98901221.6
申请日：1998-01-09
CPC分类号： A01K67/0275 , A01K2217/05 , C12N5/0043 , C12N5/0603 , C12N5/0606 , C12N5/163 , C12N2500/10 , C12N2500/12 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/84 , C12N2500/90
摘要： The present invention provides a serum-free supplement which supports the growth of embryonic stem cells in culture. Also provided are a medium comprising a basal medium supplemented with the serum-free supplement of the present invention. The present invention also provides methods for culturing and isolating embryonic stem cells, methods for producing a transgenic animal, and methods for expressing recombinant protein in embryonic stem cells and transgenic animals.
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49.发明公开COMPOSITIONS AND METHODS FOR REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (RT-PCR) 失效组合物和逆转录酶 - 聚合酶链式反应的方法（RT-PCR）
公开(公告)号：EP0975806A1
公开(公告)日：2000-02-02
申请号：EP98917984.1
申请日：1998-04-03
发明人： LEE, Jun, E. , RASHTCHIAN, Ayoub
CPC分类号： C12P19/34 , C12N9/1276 , C12N15/1096 , C12Q1/6846 , C12Q2527/149 , C12Q2527/125 , C12Q2521/107
摘要： The present invention is directed to compositions and methods useful for the amplification of nucleic acid molecules by reverse transcriptase-polymerase chain reaction (RT-PCR). Specifically, the invention provides compositions and methods for the amplification of nucleic acid molecules in a simplified one- or two-step RT-PCR procedure using combinations of reverse transcriptase and thermostable DNA polymerase enzymes in conjunction with sulphur-containing molecules or acetate-containing molecules (or combinations of such sulphur-containing molecules and acetate-containing molecules), and optionally bovine serum albumin. The invention thus facilitates the rapid and efficient amplification of nucleic acid molecules and the detection and quantitation of RNA molecules. The invention also is useful in the rapid production and amplification of cDNAs which may be used for a variety of industrial, medical and forensic purposes.
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50.发明公开REGENERATION OF BOTH PLANT TISSUES AND TRANSGENIC PLANT TISSUES USING A NEW PLANT HORMONE, 5-BROMOINDOLE-3-ACETIC ACID 失效再生BOTH与植物组织ALSO转基因植物组织使用一种新的植物激素5-溴吲哚-3-乙酸
公开(公告)号：EP0827532A4
公开(公告)日：1999-05-12
申请号：EP96913145
申请日：1996-04-26
发明人： LIN JHY-JHU , LAN JIANQING , ASSAD-GARCIA NACYRA
IPC分类号： A01G7/00 , A01H4/00 , A01N43/38 , A01N43/90 , C12N5/00 , C12N5/02 , C12N5/04 , C12N5/10 , C12N15/09 , C12N15/82
CPC分类号： C12N15/8201 , A01H4/001 , A01H4/005 , A01H4/008 , C12N5/0025
摘要： The present invention describes the use of 5-bromoindole-3-acetic acid (5-B-IAA) as an auxin affecting plant cell growth. The invention relates to the use of 5-B-IAA compositions to affect growth in monocotyledonous as well as in dicotyledonous plants. The invention also describes the use of 5-B-IAA in plant growth affecting compositions for the regeneration of both plant tissues and transgenic plant tissues. Further, the invention provides plant growth affecting compositions comprising 5-B-IAA alone or in a mixture comprising one or more additional plant growth regulators, such as cytokinin, etc.
摘要翻译： 本发明描述了使用5-溴吲哚-3-乙酸（5-B-IAA）作为影响植物细胞生长的生长素。 本发明涉及使用5-B-IAA组合物来影响生长在单子叶植物以及双子叶植物。 因此本发明描述了在植物生长的组合物影响为两个计划组织和转基因植物组织的再生中使用5-B-IAA的。 此外，本发明提供的植物生长单独或在包括一个或多个附加的植物生长调节剂的混合物的组合物影响包含5-B-IAA，如测试细胞分裂素等
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