公开(公告)号：EP1742732A1

公开(公告)日：2007-01-17

申请号：EP05739470.2

申请日：2005-05-06

申请人： SIEMENS AKTIENGESELLSCHAFT

发明人： FEHM, Udo ,  LOHF, Astrid ,  RUHL, Hermann ,  SCHNEEBERGER, Reinhold ,  SIPPL, Johann ,  WENZEL, Waldemar

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/00817 ,  B01J2219/00873 ,  B01J2219/0095

摘要： The invention relates to a micro-fluidic system consisting of modules (1) that are arranged side by side in a row, each module containing a micro-fluidic unit (6) and an associated electric control unit (15). According to the invention, the rear faces (3) of the modules (1) lie against a common vertical rear wall unit (2) and are held against said unit. In the modules (1), the respective control unit (15) is located in the vicinity of the rear face (3) and the micro-fluidic unit (6) is situated in a region that is remote from said rear face (3). The control units (15) can be connected to an electric line bus (20) that runs through the rear wall unit (2) via electric connectors (26, 27) that are located on the rear faces (3) of the modules (1) and on the rear wall unit (2) and the micro-fluidic units (6) of two respective neighbouring modules (1) are interconnected to allow the passage of fluid via a connecting part (11) that contains connection channels and that spans the relevant modules (1, 4).

公开(公告)号：EP1031375B1

公开(公告)日：2006-07-12

申请号：EP00103012.1

申请日：2000-02-15

申请人： CPC Cellular Process Chemistry Systems GmbH

发明人： Oberbeck, Sebastian ,  Schwalbe, Thomas Dr.

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/0095 ,  B01J2219/00952

公开(公告)号：EP1667794A2

公开(公告)日：2006-06-14

申请号：EP04760046.5

申请日：2004-04-20

申请人： Molecular Technologies Inc.

发明人： BUCHANAN, Charles, R. ,  PADGETT, Henry, C. ,  COLLIER, Thomas, L. ,  MATTEO, Joseph, C. ,  ALVORD, C., William

IPC分类号： B01L3/00

CPC分类号： A61K51/0491 ,  A61K51/0402 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  B01J19/0093 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0095 ,  G21G1/0005 ,  G21G4/08 ,  G21H5/02

摘要： The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment.

公开(公告)号：EP1420881A4

公开(公告)日：2006-03-08

申请号：EP02798078

申请日：2002-06-26

申请人： NU ELEMENT INC

发明人： DAVIS ERIC J ,  BOWEN RAY J ,  PEDERSEN JEFFREY M ,  FLECKNER KAREN

IPC分类号： B81B1/00 ,  B01B1/00 ,  B01J19/00 ,  C01B3/32 ,  C01B3/38 ,  C01B3/48 ,  C01B3/58 ,  F16K27/00 ,  F28D7/10 ,  F28F27/02 ,  H01M8/04 ,  H01M8/06

CPC分类号： F28F9/0278 ,  B01B1/005 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/0081 ,  B01J2219/00835 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/0095 ,  B01J2219/00957 ,  C01B3/382 ,  C01B3/48 ,  C01B3/583 ,  C01B2203/0205 ,  C01B2203/0283 ,  C01B2203/044 ,  C01B2203/047 ,  C01B2203/066 ,  C01B2203/0811 ,  C01B2203/82 ,  F16K27/003 ,  F28D7/103 ,  F28F2260/02 ,  H01M8/0612 ,  H01M8/0631 ,  H01M8/0662

摘要： A modular fluid processing architecture (10) is provided that consists of a matrix of nested tubes or processor modules (11A-D) secured between end block manifolds (12 & 13). Multiple chemical reactors may be housed in the annular spaces formed by the nesting of the tubes, and the processes may be integrated through flow splitting, mixing, switching and heat exchange in the manifolds. A flow switching system (5-9) may provide the ability to switch the flows on or off in individual processors or in banks of such processors. The switching may effect the operation of some or all of the processes. Such switching can facilitate rapid and close following of demand for the processor output while allowing each processor to run within a range of high efficiency, since processors may be turned off or on in response to falling or rising demand for the output.

公开(公告)号：EP1336432A3

公开(公告)日：2006-01-11

申请号：EP03250835.0

申请日：2003-02-11

申请人： Syrris Limited

发明人： Gilligan, Mark Peter Timothy ,  Homewood, Philip James ,  Whiffin, Rowland

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00889 ,  B01J2219/0095 ,  B01J2219/00959 ,  B01J2219/00975 ,  B01J2219/00977

摘要： A method of optimising a reaction in a microreactor. Two reaction fluids A,B as supplied to a microchannel 6 and their relative proportions are varied in a controlled manner. A sensor 13 monitors a reaction characteristic and determines the relative proportion of the fluids which optimises the yield of the reaction product. The total flow rate can also be varied at the optimum relative proportion in order to determine the maximum overall flow rate at which completion of the reactions still occurs.

摘要翻译： 一种优化微反应器中反应的方法。 提供给微通道6的两种反应流体A，B及其相对比例以受控方式变化。 传感器13监测反应特性并确定优化反应产物产率的流体的相对比例。 总流量也可以在最佳相对比例下变化，以便确定仍然发生反应完成的最大总流量。

公开(公告)号：EP1336432A2

公开(公告)日：2003-08-20

申请号：EP03250835.0

申请日：2003-02-11

申请人： Syrris Limited

发明人： Gilligan, Mark Peter Timothy ,  Homewood, Philip James ,  Whiffin, Rowland

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00889 ,  B01J2219/0095 ,  B01J2219/00959 ,  B01J2219/00975 ,  B01J2219/00977

摘要： A method of optimising a reaction in a microreactor. Two reaction fluids A,B as supplied to a microchannel 6 and their relative proportions are varied in a controlled manner. A sensor 13 monitors a reaction characteristic and determines the relative proportion of the fluids which optimises the yield of the reaction product. The total flow rate can also be varied at the optimum relative proportion in order to determine the maximum overall flow rate at which completion of the reactions still occurs.

摘要翻译： 一种在微反应器中优化反应的方法。 提供给微通道6的两个反应流体A，B及其相对比例以受控的方式变化。 传感器13监测反应特性并确定优化反应产物收率的流体的相对比例。 总流速也可以以最佳相对比例变化，以确定仍然发生反应完成的最大总流速。

公开(公告)号：EP1336431A2

公开(公告)日：2003-08-20

申请号：EP03250834.3

申请日：2003-02-11

申请人： Syrris Limited

发明人： Gilligan, Mark Peter Timothy ,  Homewood, Philip James ,  Whiffin, Rowland

IPC分类号： B01J19/00

CPC分类号： C07B49/00 ,  B01J19/0093 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/0095 ,  B01J2219/00957 ,  B01L3/5027 ,  C07B37/00

摘要： A microreactor with a sensor 9, 11 in a reaction channel 6. The sensor comprises a pair of spaced apart electrodes through which an AC voltage is passed. The amplitude and phase of the current flowing between the electrodes is monitored allowing the impedance of the reaction fluid between the electrodes to be measured.

摘要翻译： 在反应通道6中具有传感器9,11的微反应器。传感器包括一对间隔开的电极，AC电压通过该电极。 监视在电极之间流动的电流的幅度和相位，从而允许测量电极之间的反应流体的阻抗。

公开(公告)号：EP1322412A1

公开(公告)日：2003-07-02

申请号：EP01965465.6

申请日：2001-09-13

申请人： Imperial College of Science, Technology and Medicine

发明人： DE MELLO, Andrew ,  MITCHELL, Michael, Clive

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00279 ,  B01J2219/00698 ,  B01J2219/0072 ,  B01J2219/00783 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00957 ,  C40B60/14

摘要： A chemical processing system and method, the system comprising: a substrate chip including a reaction zone into which at least three different reagents are in use introduced; a reagent supply mechanism for supplying the at least three reagents to the reaction zone; and a detector for simultaneously detecting the reaction products.

公开(公告)号：EP1259315A1

公开(公告)日：2002-11-27

申请号：EP00983071.2

申请日：2000-11-13

申请人： SIEMENS AKTIENGESELLSCHAFT

发明人： HASSEL, Jörg ,  STECKENBORN, Arno

IPC分类号： B01J19/00 ,  G01N35/00

CPC分类号： B01J4/008 ,  B01J19/0093 ,  B01J2219/0002 ,  B01J2219/00813 ,  B01J2219/00815 ,  B01J2219/0095 ,  G05B15/02 ,  G05B2219/25005 ,  G05B2219/25312 ,  Y10T137/5109 ,  Y10T137/87885

摘要： The invention relates to a system for carrying out the automated processing of fluids comprising combinable and interchangeable process modules (38, 39, 40), which each contain a control unit (6) and a fluid unit (7) that can be controlled by said control unit in order to execute a module-specific process function. The control units (6) are interconnected via a data bus (10), which is shared by process modules (38, 39, 40), and the fluid units (7) are interconnected via a fluid bus (44) comprising a number of channels (45). The configuration of at least one portion of the channels (45) of the fluid buses (44) can be varied in the areas of its connection to the fluid units (7) by using configuration devices, which can be provided in the form of adapters (41, 42, 43) located between the process modules (38, 39, 40) and the fluid bus (44).

公开(公告)号：EP1021566A1

公开(公告)日：2000-07-26

申请号：EP98926498.1

申请日：1998-06-08

申请人： Caliper Technologies Corporation

发明人： KOPF-SILL, Anne, R. ,  CHOW, Andrea, W. ,  COHEN, Claudia, B. ,  SUNDBERG, Steven, A. ,  PARCE, John, Wallace

IPC分类号： C12Q1/70

CPC分类号： G01N33/557 ,  B01J19/0093 ,  B01J2219/0095 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/563 ,  B01L9/527 ,  B01L2200/14 ,  B01L2200/143 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  G01N27/447 ,  G01N27/44726 ,  G01N27/44791 ,  Y10S435/81 ,  Y10S436/805 ,  Y10S436/809

摘要： Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.