公开(公告)号：EP3132847A4

公开(公告)日：2017-12-06

申请号：EP15779692

申请日：2015-04-13

申请人： SEIKO EPSON CORP

发明人： SERA HIROSHI

IPC分类号： B01J19/00 ,  B81B1/00 ,  G01M3/16 ,  G01N27/04

CPC分类号： B01J14/00 ,  B01J19/0013 ,  B01J19/0093 ,  B01J2219/00056 ,  B01J2219/00135 ,  B01J2219/00786 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00952 ,  B01J2219/00988 ,  B81B1/00 ,  B81B2201/058 ,  B81B2203/0338 ,  G01M3/16 ,  G01N27/04 ,  G01N27/06

摘要： A chemical synthesis device which can detect leakage of a fluid out of a channel and a method of manufacturing the chemical synthesis device are to be provided. An aspect of a chemical synthesis device according to the invention includes a substrate in which a channel for chemically synthesizing a plurality of fluids with each other is formed, and a wiring portion that is embedded in the substrate, in which an electric resistance value of the wiring portion changes due to the wiring portion coming into contact with the fluids.

公开(公告)号：EP3207368A2

公开(公告)日：2017-08-23

申请号：EP15850092.6

申请日：2015-10-13

申请人： The Administrators of The Tulane Educational Fund

发明人： REED, Wayne, F.

IPC分类号： G01N30/78

CPC分类号： G01N30/78 ,  B01D2313/08 ,  B01F13/1016 ,  B01F15/0022 ,  B01F15/00227 ,  B01F15/0243 ,  B01F2013/1052 ,  B01J4/00 ,  B01J19/0093 ,  B01J19/245 ,  B01J2219/00813 ,  B01J2219/00867 ,  B01J2219/00871 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00952 ,  B01J2219/00968 ,  B01J2219/00997 ,  C12M1/34 ,  G01N1/38 ,  G01N15/02 ,  G01N2015/0092

摘要： Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.

摘要翻译： 本文公开了用于改变在串行路径中流动的解决方案的条件的设备和方法。 具体而言，本文公开的是包括化学反应器，第一系统和第二系统的装置，所述化学反应器，第一系统和第二系统各自彼此串联。 第一系统和第二系统中的每一个包括混合室，溶剂储存器，溶剂泵和一个或多个检测器。 本文还公开了一种用于改变溶液状态的方法，该方法包括使液体样品在路径中流动，当样品流过路径时将样品与至少两种离散溶剂连续混合，并且在样品是样品之后检测样品的状态 与各种溶剂混合。

公开(公告)号：EP0948408B1

公开(公告)日：2013-06-12

申请号：EP97954135.6

申请日：1997-12-03

申请人： Lawrence Livermore National Security, LLC

发明人： NORTHRUP, M., Allen

IPC分类号： G01N21/03 ,  G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L3/14

CPC分类号： B01L7/52 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00912 ,  B01J2219/00936 ,  B01J2219/00945 ,  B01J2219/00952 ,  B01L3/5027 ,  B01L3/502707 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0439 ,  B01L2400/0487 ,  B81C3/00 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  G01N2021/0346

公开(公告)号：EP1872850B1

公开(公告)日：2010-06-16

申请号：EP07252601.5

申请日：2007-06-27

申请人： JEOL Ltd.

发明人： Sakura, Satoshi

IPC分类号： B01J19/00 ,  B01L3/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00858 ,  B01J2219/00862 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00952 ,  B01L3/502707 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2400/0487 ,  G01R33/302 ,  G01R33/307 ,  H01J49/0018 ,  H01J49/165

公开(公告)号：EP2134461A1

公开(公告)日：2009-12-23

申请号：EP08745793.3

申请日：2008-04-14

申请人： Siemens Medical Solutions USA, Inc.

发明人： ELIZAROV, Arkadij M. ,  BALL, Carroll Edward ,  ZHANG, Jianzhong ,  KOLB, Hartmuth ,  VAN DAM, R. Michael ,  DIENER, Lawrence ,  FORD, Sean ,  MIRAGHAIE, Reza

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00909 ,  B01J2219/00952 ,  B01J2219/00959 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/0099 ,  C07B59/00

摘要： Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

公开(公告)号：EP1992403A1

公开(公告)日：2008-11-19

申请号：EP07301042.3

申请日：2007-05-15

申请人： Corning Incorporated

发明人： Woehl, Pierre

IPC分类号： B01F5/02 ,  B01F13/00 ,  B01J19/00

CPC分类号： B01F5/02 ,  B01F5/0602 ,  B01F5/0603 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/0094 ,  B01F13/1013 ,  B01F13/1016 ,  B01F15/06 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01J2219/00932 ,  B01J2219/00934 ,  B01J2219/00952 ,  B01J2219/00975

摘要： A microfluidic device (10) for performing chemical or biological reactions comprises a chamber (20) for use as a self-sustaining oscillating jet mixing chamber and two or more separate feed channels (22, 24, 40) separated by one or more inter-channel walls (25), the two or more channels (22,24,40) terminating at a common side (18) of the chamber (20), the two or more channels (22,24,40) having a total channel width (28) comprising the widths of the two or more channels (22,24,40) and all inter-channel walls (25) taken together, the chamber (20) having a width (26) in a direction perpendicular to the channels (22,24,40) and a length (32) in a direction parallel to the channels, the width (26) being at least two times the total channel width (28), the chamber (20) having two opposing major surfaces (56) defining a height (30) thereof, the chamber (20) having a major-surface-area to volume ratio of at least 10 cm 2 /cm 3 . A method of microfluidic fluid mixing using a self-sustaining oscillating jet mixing chamber is also disclosed.

摘要翻译： 用于进行化学或生物反应的微流体装置（10）包括腔室（20）用作通过一个或多个间隔开的自持振荡喷射混合室和两个或更多个单独的进料通道（22，24，40） 通道壁（25），所述两个或更多个通道（22,24,40）在室（20）的同一侧（18）终止，所述两个或更多个通道（22,24,40），其具有一个总的沟道宽度 （28）垂直于通道包括两个或多个信道的具有宽度（26）的宽度（22,24,40）和（25）合在一起的所有信道间的墙壁，该腔室（20）（在一个方向 22,24,40），并在平行于通道的方向上的长度（32），所述宽度（26）的至少两倍的总通道宽度（28），所述室（20）具有两个相对的主表面（56 ） - 定义的高度（30）其具有主面面积至少为10cm 2 / cm 3的体积比所述腔室（20）。 使用自持振荡喷射混合室的微流体流体混合的方法，因此是游离缺失盘。

公开(公告)号：EP0907412B1

公开(公告)日：2008-08-27

申请号：EP97931337.6

申请日：1997-06-24

申请人： Caliper Life Sciences, Inc.

发明人： PARCE, John, Wallace ,  KOPF-SILL, Anne, R. ,  BOUSSE, Luc, J.

IPC分类号： B01J19/00 ,  B01L3/00 ,  C12Q1/68

CPC分类号： G01N33/502 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0487 ,  G01N27/44791 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5064 ,  G01N33/5091 ,  G01N33/5097 ,  G01N33/5304 ,  G01N33/57415 ,  G01N35/08 ,  Y10S366/02 ,  Y10S435/81 ,  Y10S435/817 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/113332 ,  Y10T436/117497 ,  Y10T436/25

摘要： The present invention provides microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems. The device includes a series of channels (110, 112), and optional reagent channel (114), fabricated into the surface of the substrate. At least one of these channels will typically have very small cross-sectional dimensions, e.g. in the range of from about 0.1 νm to about 500 νm. The device also includes reservoirs (104, 106 and 108), disposed and fluidly connected at the ends of the channels (110 and 114). As shown, sample channel (112) is used to introduce the plurality of different test compounds into the device. As such, this channel will generally be fluidly connected to a source of large numbers of separate test compounds that will be individually introduced into the sample channel (112) and subsequently into channel (110).

公开(公告)号：EP1955762A1

公开(公告)日：2008-08-13

申请号：EP07000820.6

申请日：2007-01-16

申请人： Hitachi Plant Technologies, Ltd.

发明人： Asano, Yukako c/o Hitachi, Ltd. IP Group 12th floor ,  Oda, Masashi c/o Hitachi Plant Technologies Ltd

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/0095 ,  B01J2219/00952 ,  B01J2219/00963 ,  B01J2219/00981 ,  B01J2219/00984

摘要： The present invention is to detect leakage of fluid from a channel in a microreactor certainly at an early stage. A chemical reactor has a microreactor with a pump for sending first, second solutions, and a channel for mixing and reacting the first, second solutions. The solution sending amount of the first, second solutions to be supplied to the microreactor is controlled by a pump controlling device. The microreactor has a first substrate with a channel and a second substrate to be bonded airtightly with the first substrate. A leak detecting channel is formed in the vicinity of the channel in the first substrate.

摘要翻译： 本发明是为了在早期阶段检测微量反应器中的通道的流体泄漏。 化学反应器具有微反应器，其具有用于发送第一溶液和第二溶液的泵，以及用于混合和反应第一溶液和第二溶液的通道。 供给到微反应器的第一溶液的溶液送出量由泵控制装置控制。 微反应器具有带有通道的第一基板和与第一基板气密地接合的第二基板。 在第一基板中的通道附近形成泄漏检测通道。

公开(公告)号：EP1162455B1

公开(公告)日：2007-10-03

申请号：EP01203481.5

申请日：1995-08-01

申请人： UT-Battelle, LLC

发明人： Ramsey, Michael J.

IPC分类号： G01N27/447 ,  B01L3/00

CPC分类号： B01L3/5027 ,  B01F13/0059 ,  B01F13/0062 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00912 ,  B01J2219/00916 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01J2219/00995 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B29C65/4895 ,  B29C66/026 ,  B29C66/034 ,  B29C66/54 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/02 ,  G01N30/16 ,  G01N30/6095 ,  G01N2030/027 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/383 ,  G01N2030/8435 ,  Y10S366/01 ,  B01D15/3842

公开(公告)号：EP1666136A4

公开(公告)日：2006-09-06

申请号：EP03770124

申请日：2003-11-04

申请人： AOGAKI RYOICHI ,  ITO EIKO

发明人： AOGAKI RYOICHI ,  ITO EIKO ,  OGATA MIKIO

IPC分类号： B01J19/00 ,  B01F13/00 ,  B01L3/00 ,  C23F1/08 ,  C25D5/00 ,  C25D5/34 ,  C25D7/12

CPC分类号： B01F13/0077 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00918 ,  B01J2219/00921 ,  B01J2219/0093 ,  B01J2219/00952 ,  B01J2219/0097 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2400/043 ,  B01L2400/084 ,  C23F1/08 ,  C25D5/34

摘要： Means for enabling plating on sites of complex configuration, etching for fine complex pattern, etc. through reduction of the viscosity resistance brought about by walls of fine liquid channel of microreactor. In particular, a microreactor comprising a liquid inlet, a fine liquid channel and a liquid discharge zone characterized in that the liquid channel is formed of a magnetic barrier of band ferromagnet so that a magnetic liquid introduced through the inlet undergoes at least one operation of chemical reaction, mixing, extraction and absorption in the liquid channel. Further, there is provided means for plating or etching performed by causing a plating solution or an etching solution to flow through the liquid channel.

摘要翻译： 用于在复杂构造的位置进行电镀的方法，精细复合图案的蚀刻等。真空降低由微反应器的细液体通道壁引起的粘度阻力。 特别地，微反应器包括液体入口，细液体通道和液体排放区，其特征在于，液体通道由磁带铁磁体的磁屏障形成，使得通过入口引入的磁性液体经历至少一种化学操作 液体通道中的反应，混合，萃取和吸附。 此外，提供通过使电镀溶液或蚀刻溶液流过液体通道进行的电镀或蚀刻的装置。