公开(公告)号：EP1787979A4

公开(公告)日：2009-12-23

申请号：EP05781598

申请日：2005-09-05

Applicant: SHIONOGI & CO

Inventor： WATANABE FUMIHIKO ,  TAMURA YOSHINORI ,  YOSHIKAWA NAOKI

IPC: C07C311/00 ,  A61K31/18

CPC classification number: C07D333/34 ,  C07C311/19 ,  C07C311/29 ,  C07C311/42 ,  C07C311/46 ,  C07C323/58 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/18 ,  C07D215/12 ,  C07D307/84 ,  C07D309/08 ,  C07D333/62

公开(公告)号：EP2128161A1

公开(公告)日：2009-12-02

申请号：EP08380165.4

申请日：2008-05-30

Applicant: Ragactives, S.L.

Inventor： Silva Guisasola, Luis Octavio Ragactives, S.L.U. ,  Gorgojo Lobato, Jose Maria, Ragactives,S.L.U. ,  Gutierrez Fuentes,Luis Gerardo rAGACTIVES, s.l.u

IPC: C07D495/04 ,  C07D333/34

CPC classification number: C07D495/04 ,  C07D333/34

Abstract: The invention relates to a process for obtaining cis-4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-7,7-dioxide, its enantiomers or mixtures thereof, by reduction of 5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one-7,7-dioxide with a reducing agent which generates hydride ions. The obtained compounds are useful as intermediates in the synthesis of chiral active ingredients.

Abstract translation: 本发明涉及一种用于获得顺式-4-羟基-6-甲基-5,6-二氢-4H-噻吩并[2,3-B]噻喃-7,7-二氧化物，其对映体或它们的混合物，通过还原 5,6-二氢-6-甲基-4H-噻吩并[2,3-b]噻喃-4-酮-7,7-二氧化物与产生氢化物离子的还原剂。 将所得到的化合物可用作手性活性成分的合成中的中间体是有用的。

公开(公告)号：EP1912636A4

公开(公告)日：2009-11-18

申请号：EP06788078

申请日：2006-07-21

Applicant: ARDEA BIOSCIENCES INC

Inventor： MADERNA ANDREAS ,  VERNIER JEAN-MICHEL ,  BARAWKAR DINESH A ,  CHAMAKURA VARAPRASAD ,  ABDELLAOUI HASSAN EL ,  HONG ZHI

IPC: A61K31/44 ,  A61K31/195 ,  C07C311/08 ,  C07C311/09 ,  C07C311/10 ,  C07D207/36 ,  C07D231/18 ,  C07D233/84 ,  C07D261/10 ,  C07D277/36 ,  C07D277/54 ,  C07D307/64 ,  C07D333/34 ,  C07D333/38 ,  C07D417/04

CPC classification number: C07D307/64 ,  C07C311/08 ,  C07C311/09 ,  C07C311/14 ,  C07C311/21 ,  C07C311/28 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/36 ,  C07D231/18 ,  C07D233/84 ,  C07D261/10 ,  C07D277/36 ,  C07D277/54 ,  C07D333/34 ,  C07D333/38 ,  C07D417/04

Abstract: This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

Abstract translation: 本发明涉及作为MEK抑制剂的N-（2-芳基氨基）芳基磺酰胺，可用于治疗癌症和其它过度增生性疾病。

公开(公告)号：EP2069295A2

公开(公告)日：2009-06-17

申请号：EP07812665.3

申请日：2007-07-06

Applicant: ALLERGAN, INC.

Inventor： OLD, David, W. ,  NGO, Vinh, X.

IPC: C07C323/55 ,  C07C229/32 ,  C07C233/47 ,  C07D333/38 ,  A61K31/192 ,  A61K31/196 ,  A61K31/381 ,  A61P27/02

CPC classification number: C07C323/55 ,  C07C229/32 ,  C07C233/50 ,  C07C2601/08 ,  C07D213/70 ,  C07D213/74 ,  C07D215/26 ,  C07D215/40 ,  C07D217/04 ,  C07D257/04 ,  C07D277/56 ,  C07D307/64 ,  C07D307/68 ,  C07D307/79 ,  C07D333/34 ,  C07D333/38 ,  C07D333/62

Abstract: Disclosed herein are compounds of formula (I); methods of reducing intraocular pressure and treating glaucoma by administering these compounds and medicaments related thereto.

Abstract translation: 本文公开了下式的化合物，还公开了与之相关的治疗方法，组合物和药物。

公开(公告)号：EP2044044A2

公开(公告)日：2009-04-08

申请号：EP07812086.2

申请日：2007-06-08

Applicant: ICOS CORPORATION

Inventor： DUDLER, Thomas ,  FAROUZ, Francine ,  FOWLER, Kerry ,  HAWTHORN, Nataly ,  HUANG, Danwen ,  JUDKINS, Angela ,  KIM, Musong ,  ODINGO, Joshua ,  OLIVER, Amy ,  REED, Mark ,  RUAN, Fuqiang ,  THORSETT, Eugene

IPC: C07D295/16

CPC classification number: C07D295/205 ,  C07D207/273 ,  C07D211/46 ,  C07D211/54 ,  C07D211/76 ,  C07D213/71 ,  C07D215/36 ,  C07D223/12 ,  C07D225/02 ,  C07D239/42 ,  C07D241/08 ,  C07D261/10 ,  C07D295/155 ,  C07D295/185 ,  C07D295/26 ,  C07D313/12 ,  C07D333/34 ,  C07D405/04

Abstract: Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP 2 receptor modulation, in particular, inflammatory and immune related disorders and conditions, such as asthma, allergic rhinitis and atopic dermatitis.

Abstract translation: 提供式（I）的取代的苯乙酸化合物，药物组合物，其制备方法和方法，其可用于治疗和预防对DP 2受体调节响应的病症或病症，特别是与炎症和免疫相关的病症和 如哮喘，过敏性鼻炎和特应性皮炎。

公开(公告)号：EP1756063A4

公开(公告)日：2009-03-25

申请号：EP05745656

申请日：2005-05-04

Applicant: INCYTE CORP

Inventor： YAO WENQING ,  ZHUO JINCONG ,  XU MEIZHONG ,  ZHANG COLIN ,  METCALF BRIAN ,  HE CHUNHONG ,  QIAN DING-QUAN

IPC: C07D221/00 ,  A61K31/401 ,  A61K31/445 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/263 ,  C07D207/30 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/52 ,  C07D209/62 ,  C07D209/70 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/46 ,  C07D211/48 ,  C07D211/52 ,  C07D211/58 ,  C07D211/64 ,  C07D211/66 ,  C07D211/70 ,  C07D213/38 ,  C07D217/06 ,  C07D217/26 ,  C07D221/20 ,  C07D223/02 ,  C07D223/04 ,  C07D231/04 ,  C07D295/185 ,  C07D333/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D491/20 ,  C07D493/10 ,  C07D495/04 ,  C07D498/20 ,  C07D513/10

CPC classification number: C07D207/06 ,  A61K31/407 ,  A61K31/4439 ,  C07D207/08 ,  C07D207/10 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/27 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/52 ,  C07D209/62 ,  C07D209/70 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/46 ,  C07D211/48 ,  C07D211/52 ,  C07D211/58 ,  C07D211/64 ,  C07D211/66 ,  C07D211/70 ,  C07D213/38 ,  C07D217/06 ,  C07D217/26 ,  C07D221/20 ,  C07D295/185 ,  C07D333/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D491/107 ,  C07D491/20 ,  C07D493/10 ,  C07D495/04 ,  C07D498/20 ,  C07D513/10

Abstract: The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-ß hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

公开(公告)号：EP1409483B1

公开(公告)日：2008-12-31

申请号：EP02767208.8

申请日：2002-07-15

Applicant: Laboratoires Serono SA

Inventor： RUECKLE, Thomas ,  GOTTELAND, Jean-Pierre ,  THOMAS, Russell, J. ,  BIAMONTE, Marco

IPC: C07D409/12 ,  C07D333/34 ,  A61K31/38 ,  A61P29/00

CPC classification number: C07D409/12 ,  A61K31/38 ,  C07D333/34

Abstract: The present invention relates to sulfonamide derivatives of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are useful in the treatment of neuronal disorders, autoimmune diseases, cancer and cardiovascular diseases. Furthermore, said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and -3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation. Formula (I) IAr1 is a substituted or unsubstituted aryl or heteroaryl group; X is O or S, preferably O; Ar2 a substituted or unsubstituted arylene or heteroarylene group;R?1 and R2¿ are independently selected from the group consisting of hydrogen and a C¿1?-C6-alkyl group.

公开(公告)号：EP1983971A2

公开(公告)日：2008-10-29

申请号：EP07762448.4

申请日：2007-01-25

Applicant: Synta Pharmaceuticals Corporation

Inventor： CHEN, Shoujun ,  SUN, Lijun ,  XIE, Yu

IPC: A61K31/04 ,  A61K31/065

CPC classification number: C07D263/32 ,  C07C243/38 ,  C07C275/42 ,  C07D213/75 ,  C07D237/20 ,  C07D239/42 ,  C07D271/10 ,  C07D277/28 ,  C07D277/56 ,  C07D333/34 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to compounds of structural formula (I): Formula (I), or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, A, W1, W2, and R'1 are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

公开(公告)号：EP1968966A1

公开(公告)日：2008-09-17

申请号：EP06829848.8

申请日：2006-12-22

Applicant: Novartis AG

Inventor： CARBALLIDO HERRERA, José M. ,  JAKSCHE, Herbert ,  LEHR, Philipp ,  WERNER, Gudrun ,  WINISKI, Anthony

IPC: C07D333/34 ,  A61K31/381 ,  C07C311/14 ,  A61P29/00

CPC classification number: C07D333/34 ,  C07C311/21

Abstract: A compound of formula (I), wherein the residues have various meanings, useful as pharmaceuticals.

Abstract translation: 式（I）化合物，其中残基具有各种含义，可用作药物。

公开(公告)号：EP1966182A1

公开(公告)日：2008-09-10

申请号：EP06829847.0

申请日：2006-12-22

Applicant: Novartis AG

Inventor： CARBALLIDO HERRERA, José, M. ,  JAKSCHE, Herbert ,  LEHR, Philipp ,  WERNER, Gudrun ,  WINISKI, Anthony

IPC: C07D333/34 ,  A61K31/381 ,  A61P1/00

CPC classification number: C07D333/34

Abstract: Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is substituted by at least a cyano, carboxy or (C1-4)alkyloxycarbonyl group, are inhibitors of CCR9 activity and useful for therapeutic treatment.

Abstract translation: 其中R 1和R 2中的一个是被卤素取代的噻吩基并且R 1和R 2中的另一个是取代的苯基的式I化合物，其中取代基如权利要求中所定义，条件是该苯基被 至少氰基，羧基或（C1-4）烷氧基羰基是CCR9活性的抑制剂并可用于治疗性治疗。