-
公开(公告)号：EP2462438A4
公开(公告)日：2013-01-23
申请号：EP10807278
申请日：2010-08-06
发明人： SPAIN MICHAEL , MAPES JAMES P , LABRIE SAMUEL , MCDADE RALPH , EISINGER DOMINIC , BALLARD KARRI , SALOMON DANIEL , ABECASSIS MICHAEL
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
-
42.发明公开URINARY TRYPSIN INHIBITORS AS DIAGNOSTIC AID FOR INTERSTITIAL CYSTITIS 审中-公开HARNTRYPSINHEMMER AS辅助诊断间质性膀胱炎
公开(公告)号：EP2454387A4
公开(公告)日：2013-01-02
申请号：EP10800371
申请日：2010-07-12
发明人： PUGIA MICHAEL J
IPC分类号： C12Q1/68 , C12Q1/28 , C12Q1/37 , G01N33/558 , G01N33/573
CPC分类号： C12Q1/6883 , C12Q1/6841 , C12Q2600/158 , G01N33/558 , G01N2800/34
-
公开(公告)号：EP2462445A1
公开(公告)日：2012-06-13
申请号：EP10807275.2
申请日：2010-08-06
发明人： SPAIN, Michael, D. , MAPES, James, P. , LABRIE, Samuel, T. , MCDADE, Ralph, L. , EISINGER, Dominic , BALLARD, Karri, L.
IPC分类号： G01N33/543
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
-
44.发明公开METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF GENITOURINARY DISORDERS, INCLUDING PRE-TERM LABOR AND LEIOMYOMAS 审中-公开方法和组合物预防和两性疾病的治疗和泌尿包括早产和子宫肌瘤
公开(公告)号：EP1667630A2
公开(公告)日：2006-06-14
申请号：EP04783287.8
申请日：2004-09-07
发明人： AL-HENDY, Ayman
IPC分类号： A61K6/00
CPC分类号： C12Q1/6883 , C12Q1/48 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5091 , G01N33/57442 , G01N33/6893 , G01N2800/34 , G01N2800/36 , G01N2800/364 , G01N2800/368
摘要： The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions. Disclosed are therapeutic, preventative and diagnostic methods and compositions relating to pre-term labor, uterine diseases and conditions, and ovarian conditions and diseases. In certain embodiments, such methods and compositions involve a COMT inhibitor.
-
45.发明公开ANTIBODIES SPECIFIC FOR BLADDER NUCLEAR MATRIX PROTEINS BLCA-1 TO BLCA-6 审中-公开抗体的BUBBLES核基质蛋白BLCA-1至BLCA -6-
公开(公告)号：EP1107992A2
公开(公告)日：2001-06-20
申请号：EP99944000.1
申请日：1999-08-30
IPC分类号： C07K16/18 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57407 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , G01N33/57488 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/34
摘要： Antibodies which specifically bind to nuclear matrix proteins (NMP) BLCA-1 to BLCA-6 which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP.
-
46.发明公开METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE TOXICITY 审中-公开法OFF色素上皮衍生因子（PEDF），用于治疗和预防活性诱导性腺或子宫毒性的使用
公开(公告)号：EP3125924A1
公开(公告)日：2017-02-08
申请号：EP15774029.1
申请日：2015-03-30
发明人： SHALGI, Ruth , CHUDERLAND, Dana , BAR-JOSEPH, Hadas , GOLDBERG, Keren , BEN-AHARON, Irit , STEMMER, Salomon M.
IPC分类号： A61K38/18 , A61P15/08 , A61K31/138
CPC分类号： A61K38/18 , A61K31/138 , A61K31/704 , C12N5/0609 , C12N2501/10 , G01N33/74 , G01N2333/475 , G01N2800/34 , G01N2800/36 , G01N2800/52 , G01N2800/709 , A61K2300/00
摘要： A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.
摘要翻译： 提供治疗或预防由一种在对象中诱导剂性腺或子宫毒性的方法。 因此，提供包括给予受试者治疗有效量的色素上皮衍生因子（PEDF），从而治疗或预防由该试剂引起的性腺毒性的方法。 所以，提供的是，包括在主题确定采矿性腺功能的方法; 和给予所述受试者治疗有效量的PEDF，从而治疗或预防由药物引起的性腺毒性。 这样提供了用于通过在受试者中诱导剂性腺毒性的治疗或预防中使用的PEDF。 所以提供了细胞培养物，介质，试剂盒和用于提高卵母细胞质量体外方法。
-
公开(公告)号：EP2520648A1
公开(公告)日：2012-11-07
申请号：EP10841044.0
申请日：2010-12-28
发明人： KANEKO, Etsuji , SASAKI, Yuka , MORI, Katsuhiro , KANDA, Yutaka , SATOH, Mitsuo
IPC分类号： C12N15/09 , A61K39/395 , A61P13/12 , A61P37/02 , C07K16/42 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/53
CPC分类号： C07K16/4283 , C07K2317/34 , C07K2317/92 , G01N2800/34
摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.
-
公开(公告)号：EP2462447A1
公开(公告)日：2012-06-13
申请号：EP10807276.0
申请日：2010-08-06
发明人： SPAIN, Michael, D. , MAPES, James, P. , LABRIE, Samuel, T. , MCDADE, Ralph, L. , EISINGER, Dominic , BALLARD, Karri, L.
IPC分类号： G01N33/566 , G01N33/53
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
-
公开(公告)号：EP2462438A1
公开(公告)日：2012-06-13
申请号：EP10807278.6
申请日：2010-08-06
发明人： SPAIN, Michael , MAPES, James, P. , LABRIE, Samuel , MCDADE, Ralph , EISINGER, Dominic , BALLARD, Karri , SALOMON, Daniel , ABECASSIS, Michael
IPC分类号： G01N33/48
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
-
50.发明公开METHODS AND DEVICES FOR DETECTING DIABETIC NEPHROPATHY AND ASSOCIATED DISORDERS 审中-公开方法和设备进行检测糖尿病肾病及相关疾病
公开(公告)号：EP2462437A1
公开(公告)日：2012-06-13
申请号：EP10807277.8
申请日：2010-08-06
发明人： SPAIN, Michael, D. , MAPES, James, P. , LABRIE, Samuel, T. , MCDADE, Ralph, L. , EISINGER, Dominic , BALLARD, Karri, L.
IPC分类号： G01N33/48
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
-
-
-
-
-
-
-
-
-
搜索结果
58 条记录 (耗时 0.019 秒)
