公开(公告)号：EP1945189A2

公开(公告)日：2008-07-23

申请号：EP06848701.6

申请日：2006-11-03

申请人： Sun Pharmaceutical Industries Limited

发明人： DHARMADHIKARI, Nitin, Bhalachandra ,  ZALA, Yashoraj, Rupsinh

IPC分类号： A61K9/36 ,  A61K9/24

CPC分类号： A61K9/0065 ,  A61K9/0004 ,  A61K9/209 ,  A61K9/2866 ,  A61K31/192 ,  A61K31/198

摘要： The present invention relates to a tablet composed of a core and a coating; said core is formed by two or more layers, wherein at least one of them contains an active agent (3). Wherein one of said layers is formulated as a swellable composition (2), the other one (4) is composed of inert compounds retaining its size at least until the coated tablet is emptied from the stomach. The coating composition is selected from the group comprising water insoluble polymers, ph dependent polymers or mixtures thereof. The active agent is released after rupture of the coating.

公开(公告)号：EP1566176B1

公开(公告)日：2008-07-16

申请号：EP05250879.3

申请日：2005-02-16

申请人： Khandelwal, Sanjeev

发明人： Khandelwal, Sanjeev

IPC分类号： A61K31/43 ,  A61K31/546 ,  A61K35/74 ,  A61K9/36

CPC分类号： A61K9/2095 ,  A61K9/2077 ,  A61K9/2866 ,  A61K31/43 ,  A61K31/546 ,  A61K35/742 ,  A61K2300/00

摘要： A synergistic antibacterial formulation and a method of making the same is disclosed. The composition contains Cefixime Trihydrate + Cloxacillin Sodium + Lactobacillus sporogenes spores. The Cloxacillin sodium is in two forms in a sustained release and an immediate release form. A drug delivery system for providing the formulation is provided.

公开(公告)号：EP1713454A4

公开(公告)日：2008-07-02

申请号：EP04783640

申请日：2004-09-10

申请人： GLYKON TECHNOLOGIES GROUP LLC

发明人： CLOUATRE DALLAS L ,  DUNN JAMES M

IPC分类号： A61K9/28 ,  A61K9/30 ,  A61K9/32 ,  A61K9/34 ,  A61K9/36 ,  A61K9/48 ,  A61K9/66

CPC分类号： A61K9/2866 ,  A61K9/2846 ,  A61K9/4891

公开(公告)号：EP1545455B1

公开(公告)日：2008-04-30

申请号：EP03769327.2

申请日：2003-09-24

申请人： Universiteit Gent

发明人： REMON, Jean Paul ,  MEHUYS, Els ,  VERVAET, Chris

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/36

CPC分类号： A61K9/2054 ,  A61K9/2013 ,  A61K9/2866

摘要： A biologically active composite solid shaped article comprising: (a) an outer layer, and (b) an inner core filling the said outer layer and comprising: - at least a biologically active ingredient, and - an excipient comprising at least a hydrophilic cellulose polymer and an amphiphilic material in the form of a blend with the said hydrophilic cellulose polymer, the weight ratio of the hydrophilic cellulose polymer to the amphiphilic material being from 0.2:1 to 0.6:1, provides improved sustained release of the biologically active ingredient.

公开(公告)号：EP1909763A2

公开(公告)日：2008-04-16

申请号：EP06800574.3

申请日：2006-07-28

申请人： ISP INVESTMENTS INC.

发明人： OLSEN, Stephen ,  DONEY, John, Alfred ,  SHORES, Christophen, Steven

IPC分类号： A61K9/16 ,  A61K9/26 ,  A61K9/48 ,  A61K9/36 ,  A61K31/122 ,  A61P9/00

CPC分类号： A61K31/122 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K31/12

摘要： Benzoquinone compositions of enhanced solubility and bioavailability are described that contain at least one benzoquinone with at least one solubility-enhancing polymer. In one embodiment, the benzoquinone is coenzyme Q10. Described methods to produce the bioenhanced products comprise dry blending and solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising benzoquinone, a solubility-enhancing polymer and a solvent and removing the solvent to form amorphous benzoquinone. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.

公开(公告)号：EP1820506B1

公开(公告)日：2008-03-26

申请号：EP06250764.5

申请日：2006-02-13

申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD.

发明人： Leibovici, Minutza ,  Kanari, Itamar ,  Fox, Michael

IPC分类号： A61K31/519 ,  A61K31/616 ,  A61K9/16 ,  A61K9/24 ,  A61K9/32 ,  A61K9/36 ,  A61K9/48 ,  A61P7/02

CPC分类号： A61K9/4808 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2846 ,  A61K9/5084 ,  A61K31/519 ,  A61K31/616 ,  A61K45/06

公开(公告)号：EP1898888A2

公开(公告)日：2008-03-19

申请号：EP06785833.2

申请日：2006-06-28

申请人： Wyeth

发明人： CHATLAPALLI, Ramarao, S. ,  NAGL, Arwinder ,  VAN PELT, Lawrence

IPC分类号： A61K9/36 ,  A61K31/565 ,  A61K31/55

CPC分类号： A61K9/209 ,  A61K31/55 ,  A61K31/565

摘要： The present invention relates to solid dosage formulations containing conjugated estrogens and bazedoxifene, or a salt thereof. In some embodiments, the compositions include a core comprising conjugated estrogens, and at least one coating that comprises bazedoxifene, or a salt thereof.

公开(公告)号：EP1474113A4

公开(公告)日：2008-02-27

申请号：EP02806866

申请日：2002-04-22

申请人： FMC CORP

发明人： AUGELLO MICHAEL

IPC分类号： A23G3/34 ,  A23L1/00 ,  A61K9/20 ,  A61K9/28 ,  A61K9/36 ,  A61K47/24 ,  A61K47/36 ,  A61K47/38 ,  C05G5/00 ,  C08L1/28 ,  C08L3/02 ,  C08L5/00 ,  C08L71/02 ,  C09D105/04 ,  C09D105/06 ,  C09K3/00 ,  C09D101/28 ,  C09D103/02

CPC分类号： A23G3/343 ,  A23G2200/00 ,  A23P20/105 ,  A23V2002/00 ,  A61K9/2072 ,  A61K9/282 ,  A61K9/286 ,  C08L1/284 ,  C08L3/02 ,  C08L5/00 ,  C08L71/02 ,  C09D105/04 ,  C09D105/06 ,  C08L2666/26 ,  C08L2666/02 ,  A23V2200/22 ,  A23V2250/5026 ,  A23V2250/1842 ,  A23V2250/5114 ,  A23V2250/612

摘要： An edible, hardenable coating composition is disclosed which comprises high levels of low viscosity propylene glycol alginate and which may additionally contain a surfactant, a filler, a pigment, and optionally a small amount of a secondary film former and/or a strengthening polymer. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.

公开(公告)号：EP1888042A2

公开(公告)日：2008-02-20

申请号：EP06770085.6

申请日：2006-05-09

申请人： Warner-Lambert Company LLC

发明人： KOLL, Greogry Edwin ,  MODY, Seema Kirtikumar

IPC分类号： A61K9/36

CPC分类号： A61K9/0058

摘要： A chewing gum comprising at least one active pharmaceutical ingredient (API) within the core onto which is applied at least one inner polymer film coating and thereafter onto which is applied at least one outer hard coating. A preferred API is nicotine. Flavoring agents may be incorporated in the core, in the at least one inner polymer film coating and/or in the at least one outer hard coating. The gums formed exhibit a long lasting effect of flavoring agent (s) and result in the domination of flavoring agents in the coating (s) over flavoring agent (s) in the core, thereby (a) avoiding problems of chemical or pharmaceutical incompatibility between an API in the core and flavoring agent (s) in the coating (s) and (b) achieving an increased control of the release of the API and of non-active excipients.

公开(公告)号：EP1455832B1

公开(公告)日：2008-02-20

申请号：EP02790247.7

申请日：2002-12-20

申请人： Universiteit Gent

发明人： DEMEESTER, Jo ,  DE SMEDT, Stefaan ,  STUBBE, Barbara

IPC分类号： A61K47/36 ,  A61K9/36 ,  A61K9/62

CPC分类号： A61K9/0019 ,  A61K9/1652 ,  A61K9/205 ,  A61K47/36 ,  C08L5/02

摘要： A degradable oligomer or polymer aqueous solution or a degradable polymer hydrogel, wherein degradation occurs by cleavage of the oligomer or polymer backbone and/or, in the case of a hydrogel, by cleavage of cross-linking bonds within the hydrogel, is useful as a component of a time-controlled explosion bio-agent release system or a pulsed bio-agent delivery system comprising at least one biologically active agent and an outer semi-permeable lipid or polymer membrane, wherein bio-agent release or delivery begins after a lag time.