公开(公告)号：EP0754665A3

公开(公告)日：1997-09-10

申请号：EP96401598.6

申请日：1996-07-18

Applicant: Mitsubishi Chemical Corporation

Inventor： Tanaka, Ken, c/o Mitsubishi Chem. Corp. ,  Katsurada, Manabu, c/o Mitsubishi Chem. Corp. ,  Hosokawa, Akemi, c/o Mitsubishi Chem. Corp.

IPC: C07C22/04 ,  C07C25/02 ,  C07C17/14

CPC classification number: C07D303/08 ,  C07C17/14 ,  C07C17/25 ,  C07C22/04 ,  C07C25/02 ,  C07C25/28

Abstract: A novel 3-substituted α,β-dibromoethylbenzene of formula (I):
wherein X represents a halogen atom or a trihalomethyl group, which is a useful intermediate for pharmaceuticals or agricultural chemicals, is prepared by a simple and high yield process which comprises reacting a 3-substituted α-bromoethylbenzene represented by formula (II):
wherein X is as defined above,
or a 3-substituted ethylbenzene represented by formula (III):
wherein X is as defined above, with bromine in the presence of a quaternary ammonium salt.

Abstract translation: 式（I）的新型3-取代的α，β-二溴乙基苯：其中X代表卤素原子或三卤代甲基，其是药物或农药的有用中间体，其通过简单且高产率的方法制备 其包括使由式（II）表示的3-取代的α-溴乙基：其中X如上所定义的3-取代的α-溴乙苯或由式（III）表示的3-取代的乙基苯：其中X如上所定义， 在溴化季铵盐的存在下。

公开(公告)号：EP0541793B1

公开(公告)日：1997-01-08

申请号：EP92924469.7

申请日：1992-05-26

Applicant: MERCK PATENT GmbH

Inventor： BARTMANN, Ekkehard ,  PLACH, Herbert ,  EIDENSCHINK, Rudolf ,  REIFFENRATH, Volker ,  PAULUTH, Detlef ,  POETSCH, Eike ,  SCHOEN, Sabine ,  MEYER, Volker ,  JUNGE, Michael ,  HITTICH, Reinhard

IPC: C09K19/30 ,  C07C43/192 ,  C07C25/24 ,  C07C43/225 ,  C07C22/04 ,  C07C22/00

CPC classification number: C07D239/26 ,  C07C22/00 ,  C07C22/04 ,  C07C22/08 ,  C07C25/24 ,  C07C43/192 ,  C07C43/225 ,  C07C381/00 ,  C07C2601/14 ,  C07D213/26 ,  C07D319/06 ,  C09K19/3001 ,  C09K19/3003 ,  C09K19/3028 ,  C09K2019/0444

Abstract: The invention concerns vinyl compounds of formula (I), in which R is H, an alkyl or alkenyl group with 1 to 15 C-atoms which may be unsubstituted, substituted singly by CN or CF3 or substituted at least singly by halogen, one or more CH2 units in these groups being replaceable, independently of each other by -O-, -S-, (α), -CO-, -CO-O-, -O-CO- or -O-CO-O- in such a way that O-atoms are not linked directly to each other; A?1 and A2¿, independently of each other, are (a) a trans-1,4-cyclohexylene group in which one or more non-adjacent CH¿2? groups can be replaced by -O- and/or -S-, (b) a 1,4-phenyl group in which one or two CH groups can be replaced by N, (c) a 1,4-cyclohexenylene, 1,4-bicyclo(2,2,2)octylene, piperidine-1,4-diyl, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl or 1,2,3,4-tetrahydronaphthalene-2,6-diyl group, where the groups (a) and (b) may be substituted by CN or fluorine; Z?1 and Z2¿, independently of each other, are -CO-O-, -O-CO-, -CH¿2?O-, -OCH2-, -CH2CH2-, -CH=CH-, -C=C- or a single bond, one of the groups Z?1 and Z2¿ may also be -(CH¿2?)4- or -CH=CH-CH2CH2-; Q is a single bond, -O-, -CH2-CH2-, -C=C-, trans-CH=CH-, -COO- or -CH2O-; X?1¿ is H, F or Cl; X2 is F, Cl, CF¿3? or SF5; Y is H, F or Cl; r is 0 to 4; n is 0 or 1; and m is 0, 1, 2 or 3; with the proviso that, when Y = H and Q = single bond, X?1 and X2¿ are Cl. Such compounds are suitable for use as components of liquid-crystal media.

Abstract translation: PCT No.PCT / EP92 / 01185 Sec。 371日期：1992年8月5日 102（e）日期1992年8月5日PCT提交1992年5月26日PCT公布。 出版物WO92 / 21734 日期为1992年12月10日。式I的化合物（IMAGE），其中变量如权利要求中所述。 这些化合物可用作液晶介质中的组分。

公开(公告)号：EP0563033B1

公开(公告)日：1997-01-02

申请号：EP90915845.3

申请日：1990-10-26

Applicant: CHEVRON U.S.A. Inc.

Inventor： SCHINSKI, William, L. ,  DENISEVICH, Peter, Jr.

IPC: C07C253/14 ,  C07C22/04 ,  C07C22/08 ,  C07C255/35 ,  C07C17/20

CPC classification number: C07C255/35 ,  C07C17/14 ,  C07C17/202 ,  C07C17/204 ,  C07C17/206 ,  C07C22/04 ,  C07C22/08

Abstract: A method is provided for forming (3-trifluoromethyl-phenyl)acetonitrile through the intermediate α, α, α-trifluoro-α'-chloro-m-xylene. This intermediate is formed by selective chlorination of α, α, α'-trichloro-m-xylene under conditions which maximize yield and minimize the formation of undesired, non-recyclable chlorinated by-products.

Abstract translation: 提供了通过中间体α，α，α-三氟-α' - 氯 - 间二甲苯形成（3-三氟甲基苯基）乙腈的方法。 该中间体通过在最大化产率和最小化不期望的不可回收氯化副产物的形成的条件下选择性氯化α，α，α'-三氯间二甲苯形成。

公开(公告)号：EP0441951B1

公开(公告)日：1996-07-10

申请号：EP90914154.1

申请日：1990-08-30

Applicant: MERCK PATENT GmbH

Inventor： HITTICH, Reinhard ,  POETSCH, Eike ,  REIFFENRATH, Volker ,  RIEGER, B. Wacoe, Tamagawagakuen 2834, Ootadaira ,  WÄCHTLER, Andreas ,  COATES, David ,  PLACH, Herbert

IPC: C07C22/08 ,  C09K19/30 ,  G02F1/13 ,  C07C25/18 ,  C07C22/04 ,  C07C255/50 ,  C07C43/225

CPC classification number: C09K19/3028 ,  C07C22/08 ,  C07C25/18 ,  C07C43/225 ,  C07C255/50 ,  C07C2601/14 ,  C09K19/3003 ,  C09K2019/3021

Abstract: New halogenated benzene derivatives of formula (I), where n is 1 to 7, the rings A and B each stand for trans-1,4-cyclohexylene, or one of the rings A and B also stands for 1,4-phenylene or 3-fluor-1,4-phenylene, X F, Cl, -CHF2, -CF3, -CN, -OCF3 or -OCHF2, Y and Z each independently stand for H or F, r = 1 or, if s = 1, B = trans-1,4-cyclohexylene and simultaneously X = -CHF2, -CF3, -OCF3 or -OCHF2 and r = 0, and s = 1 or, if B = 1,4-phenylene or 3-fluor-1,4-phenylene, s = 0.

Abstract translation: 本发明涉及式I的卤代苯衍生物，其中n为1至7 [sic]，环A和B各自为反-1,4-亚环己基或环A和B之一 或者1,4-亚苯基或3-氟-1,4-亚苯基，X是F，C1，CHF2，-CF3，-CN，-OCF3或-OCHF2，Y和Z彼此独立地为H 或F，r = 1，或者在s = 1的情况下，B =反式-1,4-亚环己基，同时X = -CHF 2，-CF 3，-OCF 3或-OCHF 2，r为0，s = 1 或者在B = 1,4-亚苯基或3-氟-1,4-亚苯基的情况下，s = 0。

公开(公告)号：EP0693100A4

公开(公告)日：1996-04-24

申请号：EP94912399

申请日：1994-04-07

Applicant: GREAT LAKES CHEMICAL CORP

Inventor： MACK ARTHUR G ,  MAMUZIC RASTKO I ,  SANDERS DAVID C ,  ROSE RICHARD S ,  HARSCHER MARY G

IPC: B01J23/745 ,  B01J27/128 ,  C07B61/00 ,  C07C17/12 ,  C07C17/38 ,  C07C17/392 ,  C07C25/18 ,  C08K5/02 ,  C08K5/03 ,  C08L101/00 ,  C09K21/08 ,  C09K21/00 ,  C07C17/10 ,  C07C22/04 ,  C07C25/20

CPC classification number: C07C17/12 ,  C07C17/392 ,  C07C25/18

Abstract: Described are processes for preparing brominated diphenylalkane products which are far whiter than prior known brominated diphenylalkane products. The resultant white brominated diphenylalkane products also form a part of the present invention, as do formulations incorporating the white brominated diphenylalkane products, and articles prepared therefrom.

公开(公告)号：EP0676388A2

公开(公告)日：1995-10-11

申请号：EP95104285.2

申请日：1995-03-23

Applicant: BAYER AG

Inventor： Lantzsch, Reinhard, Dr. ,  Fuchs, Rainer, Dr.

IPC: C07C51/34 ,  C07C57/32 ,  C07C17/26 ,  C07C22/04 ,  C07C43/303

CPC classification number: C07C51/285 ,  C07C17/266 ,  C07C22/04 ,  C07C43/303 ,  C07C51/34 ,  C07C57/30 ,  C07C59/64

Abstract: Die Erfindungs betrifft neue Verfahren zur Herstellung von zum Teil bekannten Phenylessigsäurederivaten der Formel (I)

   in welcher R¹, R² und R³ unabhängig voneinander jeweils für Wasserstoff, Alkyl oder Alkoxy stehen, durch Ozonolyse von Verbindungen der Formel (II)

   in welcher R⁴ für Wasserstoff oder Methyl steht und Oxidation der daraus erhaltenen Reaktionsprodukte. Die Erfindung betrifft ferner neue Zwischenprodukte und ein Verfahren zu deren Herstellung.

Abstract translation: 本发明涉及一种新方法用于制备式（I）其中R 1，R 2和R 3彼此独立地各自代表氢，烷基或烷氧基，由式I化合物的臭氧分解（II）的已知部分苯乙酸衍生物的制备 其中R <4>是由其获得的反应产物的氢或甲基，和氧化。 本发明还涉及新的中间体和它们的制备的方法。

公开(公告)号：EP0675095A1

公开(公告)日：1995-10-04

申请号：EP95103583.1

申请日：1995-03-13

Applicant: HOECHST AKTIENGESELLSCHAFT

Inventor： Kleiner, Hans-Jerg, Dr. ,  Regnat, Dieter, Dr. ,  Röschert, Horst, Dr.

IPC: C07C17/14 ,  C07C22/04 ,  B01J19/12

CPC classification number: C07C17/14 ,  C07C22/04

Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 2,2'-Bis(halogenmethyl)-1,1'-binaphthyl, indem man 2,2'-Dimethyl-1,1'-binaphthyl in Anwesenheit eines Lösungsmittels mit einem Halogenierungsmittel unter Einwirkung von Licht einer Wellenlänge von 10⁻⁵ bis 10⁻⁸ m in Anwesenheit oder Abwesenheit eines Radikalbildners bei -10 bis 120 °C umsetzt.

Abstract translation: 产品 的2,2'-双（卤代甲基）-1,1'-联萘（I）包括在-10至120℃下使2,2'-二甲基-1,1'-联萘（II）与卤化剂（III）反应 在波长为10 -5 -10 -10 m的光的作用下，在溶剂和选择性的情况下。 激进的发电机。 县。 反应在惰性溶剂中进行， （II）：溶剂= 1：（3-40），优选1：（4-20），特别优选1：（5-15）预溶剂是氯化苯，氯化脂族烃， 或1-6C脂族羧酸和1-4C链烷醇的酯，优选CH 2 Cl 2，氯苯（MCB）和/或二氯苯（DCB），特别是MCB和/或DCB，更特别优选MCB。摩尔比 （II）：（III）= 1：（1.5-2.5），优选1：（1.8-2.3），特别是1：（1.9-2.2）。（III）是氯化或溴化剂， 氯，N-氯代琥珀酰亚胺（NCS），溴，N-溴 - 琥珀酰亚胺（NBS），1,3-二溴-5,5-二甲基乙内酰脲或溴 - 梅德鲁辛酸，尤其是NCS，溴或NBS，光源 是常规的UV发射体，合适的自由基发生剂是有机过氧化物，过氧羧酸，氢过氧化物或偶氮cpds，过氧化苯甲酰，十六烷酸苯甲酰酯或AIBN

公开(公告)号：EP0609588A3

公开(公告)日：1995-09-06

申请号：EP93203676.7

申请日：1993-12-24

Applicant: NYCOMED IMAGING AS

Inventor： Josef, Kurt A., c/o Sterling Winthrop Inc. ,  Bacon, Edward R., c/o Sterling Winthrop Inc. ,  Estep, Kimberley G., c/o Sterling Winthrop Inc. ,  Illig, Carl, c/o Sterling Winthrop Inc. ,  Douty, Brent D., c/o Sterling Winthrop Inc.

IPC: A61K49/04 ,  C07C22/04 ,  C07C25/02

CPC classification number: C07C17/354 ,  A61K49/0438 ,  A61K49/0461 ,  C07C17/12 ,  C07C17/2635 ,  C07C25/02 ,  C07C25/24 ,  C07C69/65

Abstract: Disclosed are contrast agents of the formula

or pharmaceutically acceptable salts thereof,
contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
R = C 1 -C 25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxycarbonyl or lower-alkoxycarbonyloxy, (CR i R 2 )p-(CR 3 =CR 4 ) m Q, or (CR 1 R 2 )p-C=C-Q; Ri, R 2 , R 3 and R 4 are independently H, lower-alkyl, optionally substituted with halo; n is 1-5; m is 1-5; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

Abstract translation: 口服或直肠给药的X线对照组合物。 包括具有式（I）的造影剂或（I）的盐。 药学上可接受的载体 选自两性离子表面活性剂，三甲基溴化铵，月桂基硫酸钠，十七烷基硫酸钠，烷基苯磺酸，丁基萘磺酸钠，琥珀酸丁磺酸盐，羧酸酯，羧酸酰胺，乙氧基化烷基酚和乙氧基化脂族醇的至少一种表面活性剂，脱水山梨醇酯，聚氧乙烯 烷基醚和聚氧乙烯山梨糖醇酐脂肪酸酯。 R = CH 3，C 2 H 5，n-C 3 H 7，4-25 C烷基，环烷基，不饱和的。 烯丙基（sic）或卤代低级烷基，其各自可以选择。 被删除 （CR 1 R 2）p - （CR 3 = CR 4）m Q或（CR 1 R 2）p -C CC-Q; R1，R2，R3和R4各自独立地为H或opt。 晕子 低级烷基，n为2-5，m为2-5，p为1-10，Q为H，低级烷基，烯基，低级炔基，低级亚烷基（sic），芳基或芳基 - 低级烷基。

公开(公告)号：EP0609586A3

公开(公告)日：1995-09-06

申请号：EP93203674.2

申请日：1993-12-24

Applicant: NYCOMED IMAGING AS

Inventor： Illig, Carl, c/o Sterling Winthrop Inc. ,  Cooper, Eugene R., c/o Sterling Winthrop Inc. ,  Toner, John L., c/o Sterling Winthrop Inc. ,  Upson, Donald, c/o Sterling Winthrop Inc. ,  Douty, Brent D., c/o Sterling Winthrop Inc. ,  Caulfield, Thomas J., c/o Sterling Winthrop Inc. ,  Bacon, Edward R., c/o Sterling Winthrop Inc. ,  Estep, Kimberley G., c/o Sterling Winthrop Inc. ,  Josef, Kurt A., c/o Sterling Winthrop Inc. ,  Robinson, Shaughnessy, c/o Sterling Winthrop Inc. ,  Spara, Paul P., c/o Sterling Winthrop Inc.

IPC: A61K49/04 ,  C07C22/04

CPC classification number: A61K49/0404 ,  A61K49/04 ,  A61K49/0409 ,  A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

Abstract: Disclosed are contrast agents of the formula

or pharmaceuticaoly acceptable salts thereof,
contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
Z = H, halo, C₁-C₂₀ alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C₁-C₂₅ alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR₁R₂) p - (CR₃ = CR₄) m Q, or (CR₁R₂) p - C ≡ C - Q; R₁, R₂, R₃ and R₄ are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

公开(公告)号：EP0637580A1

公开(公告)日：1995-02-08

申请号：EP94112364.8

申请日：1994-08-08

Applicant: SUMITOMO CHEMICAL COMPANY LIMITED

Inventor： Fujishima, Hiroaki ,  Miyamoto, Yasunobu ,  Minai, Masayoshi ,  Matsumoto, Tsutomu ,  Ushio, Hideki ,  Higashii, Takayuki

IPC: C07C22/04 ,  C07C17/08 ,  C07C15/44 ,  C07C1/32 ,  C07F3/02

CPC classification number: C07C17/2632 ,  C07C15/44 ,  C07C17/08 ,  C07C17/087 ,  C07C41/22 ,  C07F3/02 ,  C07C22/04 ,  C07C43/225

Abstract: A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.

Abstract translation: 通过在非极性溶剂的存在下使苯基烯烃衍生物与溴化氢反应来制备1-溴烷基苯衍生物。 苯基烯烃衍生物通过烯基卤化物与金属镁反应形成格氏试剂制备，然后使格利雅试剂与苄基卤衍生物反应。 通过使烯丙基卤衍生物与金属镁在有机溶剂中连续反应制备烯丙基格氏试剂，其中将烯丙基卤衍生物和金属镁连续加入到反应体系中，形成的烯丙基格氏试剂从反应体系中连续除去 。 该方法以高产率，高选择性和高纯度提供目标化合物。