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1057 条记录 (耗时 0.029 秒)

    PROCEDE DE PRODUCTION ENZYMATIQUE D'UN AGENT DE TRAITEMENT A L'ETAT FLUIDE
    42.
    发明授权
    PROCEDE DE PRODUCTION ENZYMATIQUE D'UN AGENT DE TRAITEMENT A L'ETAT FLUIDE 有权
    方法酶法生产处理剂固化前的

    公开(公告)号：EP1390480B1

    公开(公告)日：2011-11-02

    申请号：EP02738292.8

    申请日：2002-05-31

    申请人： TMI Europe

    发明人： CASEZ, Hervé

    IPC分类号： C12N9/08 ,  C12P3/00 ,  C12N11/00 ,  A61L2/16 ,  A01N59/24 ,  A01N63/00 ,  C12M1/40

    CPC分类号： C12N9/0065 ,  A61L2/16 ,  C12M21/18 ,  C12M23/34 ,  C12M27/02 ,  C12M33/10 ,  C12M33/14 ,  C12M33/22 ,  C12M41/26 ,  C12N11/00 ,  C12P3/00

    摘要： The invention relates to a method for the enzymatic production of a curing agent in its fluid state, e.g. liquid, comprising, in free phase, at least one oxygenated chemical species. Said method consists in bringing into contact at least: one enzymatic catalysis agent, comprising at least one peroxidase-type enzyme; an oxidisable substrate in aqueous phase that can be oxidised by the action of an oxygen donor, by catalysis by said enzymatic catalysis agent, generating said oxygenated chemical species in free phase; and said oxygen donor. The inventive method is characterised in that: e) an aqueous reaction bath is formed comprising, in addition to the oxidisable substrate and the oxygen donor, said enzymatic catalysis agent in divided solid phase, but in free phase, distributed in said bath, which may be set in motion; f) the aqueous reaction bath is separated into a fraction enriched with the enzymatic catalysis agent in divided solid phase and a fraction free from said catalysis agent, from which the curing agent is obtained.

    METHOD FOR PRODUCING A FATTY ACID BY USE OF AN IMMOBILIZED ENZYME
    44.
    发明授权
    METHOD FOR PRODUCING A FATTY ACID BY USE OF AN IMMOBILIZED ENZYME 有权
    METHOD FOR产生脂肪AUERE通过使用固定化酶

    公开(公告)号：EP1931776B1

    公开(公告)日：2011-09-28

    申请号：EP06811556.7

    申请日：2006-10-04

    申请人： Kao Corporation

    发明人： SAITO, Jun ,  SENDA, Yoshitaka ,  KOMATSU, Toshiteru

    IPC分类号： C12N11/00 ,  C12M1/40

    CPC分类号： C12N9/20 ,  C12N11/00 ,  C12P7/6418

    摘要： The present invention provides a method for producing a useful substance by supplying, to a fixed-bed reactor packed with an immobilized enzyme, a liquid mixture containing two liquid phases, in which the two liquid phases are allowed to flow in an identical, parallel direction, which method employs a fixed-bed reactor equipped with an insertion unit or tubes, so as to form a plurality of lumens in the fixed-bed reactor, each lumen having a cross section of a circular shape with a diameter of 100 mm or less or having a polygonal shape with a diagonal line of 100 mm or less, wherein the lumens are packed with an immobilized enzyme and the liquid mixture is supplied therethrough. In a reaction performed by passing a reaction mixture exhibiting two liquid phases through a fixed-bed reactor equipped with an immobilized enzyme, overall flow of the reaction liquid is made uniform, to thereby facilitate production of a useful substance in an efficient manner.

    LOVASTATIN ESTERASE ENZYME IMMOBILIZED ON SOLID SUPPORT, PROCESS FOR ENZYME IMMOBILIZATION, USE OF IMMOBILIZED ENZYME, BIOCATALYTIC FLOW REACTOR AND PROCESS FOR PREPARATION AND/OR PURIFICATION OF SIMVASTATIN
    48.
    发明公开
    LOVASTATIN ESTERASE ENZYME IMMOBILIZED ON SOLID SUPPORT, PROCESS FOR ENZYME IMMOBILIZATION, USE OF IMMOBILIZED ENZYME, BIOCATALYTIC FLOW REACTOR AND PROCESS FOR PREPARATION AND/OR PURIFICATION OF SIMVASTATIN 有权
    在固体载体上固定化的洛伐他汀酯酶，METHOD酶固定，生物催化流反应器和方法用于产生和/或辛伐他汀清洁

    公开(公告)号：EP2240569A1

    公开(公告)日：2010-10-20

    申请号：EP08851525.9

    申请日：2008-11-18

    申请人： Instytut Chemii Organicznej, Polska Akademia Nauk

    发明人： OSTASZEWSKI, Ryszard ,  KOSZELEWSKI, Dominik ,  KUREK, Waldemar ,  PATRALSKA, Dorota

    IPC分类号： C12M1/40 ,  C12N11/08 ,  C12N11/12 ,  C12P17/06

    CPC分类号： C12N11/06 ,  C12N9/16 ,  C12N11/08 ,  C12N11/10 ,  C12N11/12

    摘要： The invention relates to the lovastatin esterase enzyme immobilized on a solid support insoluble in water, the enzyme being covalently bound to a solid support activated with an at least difunctional coupling reagent, the immobilized lovastatin esterase exhibiting at least 5 times higher the hydrolytic activity towards lovastatin and salts thereof, in the presence of simvastatin and/or salts thereof, than towards simvastatin and salts thereof. The invention also relates to a process for immobilization of the lovastatin esterase enzyme on a solid support insoluble in water, and use of the enzyme immobilized on a solid support for preparation and/or isolation and/or purification of simvastatin, and also to a process for preparation and/or purification of simvastatin comprising treating the solution of the simvastatin salt containing residual content of the lovastatin salt with the lovastatin esterase enzyme until hydrolysing lovastatin to form the triol; separating the triol; and isolating simvastatin substantially free from lovastatin, wherein the solution of the simvastatin salt containing residual content of the lovastatin salt, is brought into a contact with the lovastatin esterase enzyme immobilized on a solid support insoluble in water. Also, the invention relates to a biocatalytic flow reactor with a bed, comprising a body (1) of the reactor with an inner space (2) connected to the fluid inlet (3) and connected to the fluid outlet (4), in which inner space (2) there is a bed (5) containing the lovastatin esterase enzyme immobilized on a solid support insoluble in water.