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41.发明公开
公开(公告)号：EP4011912A1
公开(公告)日：2022-06-15
申请号：EP21743662.5
申请日：2021-01-22
发明人： AYABE Tokiyoshi , NAKAMURA Kiminori
IPC分类号： C07K16/18 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/13 , C12N15/63 , G01N33/53 , G01N33/531 , G01N33/543
摘要： [Problem] The purpose of the present invention is to provide a method for detecting, in a selective and simple manner, an oxidized form of HD5 which is human α-defensin, that is, HD5 having intramolecular disulfide bonds that function beneficially in the human body.
[Solution] The present invention relates to: two kinds of novel monoclonal antibodies that contain amino acid sequences of SEQ ID NO: 1-6 or 7-12 as a CDR and that specifically bind to human α-defensin HD5 having intramolecular disulfide bonds; an immunological detection method using the antibodies; and a kit containing the antibodies.-
公开(公告)号：EP4006163A1
公开(公告)日：2022-06-01
申请号：EP20843486.0
申请日：2020-07-22
申请人： Daicel Corporation
IPC分类号： C12P17/06 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/31 , C12N15/52 , C12N15/53 , C12N15/63 , C12N9/00 , C12N9/02
摘要： An object of the present disclosure is, at least, to provide an enzyme that dehydroxylates hydroxyl groups at predetermined positions of urolithins having hydroxyl groups at the predetermined positions, and the object can be solved by an enzyme having the following properties (1) and (2): (1) dehydroxylating a hydroxyl group at the 4-position of urolithins; and (2) in the presence of methyl viologen (MV), being activated by one or more components selected from the group consisting of: reduced nicotinamide adenine dinucleotide (NADH); reduced nicotinamide adenine dinucleotide phosphate (NADPH); flavin adenine dinucleotide (FAD); and flavin adenine mononucleotide (FMN).
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44.发明公开
公开(公告)号：EP3954756A1
公开(公告)日：2022-02-16
申请号：EP19924352.8
申请日：2019-09-06
发明人： NAKAYASHIKI, Toru
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C12N9/88 , C12N15/60 , C12P7/42 , C12P7/46 , C12P13/06 , C12P13/20
摘要： The present disclosure pertains to a genetically modified microorganism that satisfies some of specific requirements. The specific requirements include: (I) compared to a wild type microorganism, having reduced or inactivated succinate dehydrogenase activity or fumarate reductase activity; (II) compared to a wild type microorganism, having reduced or inactivated lactate dehydrogenase activity; (III) having a modified phosphoenolpyruvate carboxylase activity and thus showing resistance against the feedback inhibition by aspartic acid in wild type phosphoenolpyruvate carboxylase activity, or having an exogenous phosphoenolpyruvate carboxylase activity and thus showing higher resistance against the feedback inhibition by aspartic acid than wild type phosphoenolpyruvate carboxylase activity shown by a wild type microorganism; and (IV) compared to a wild type microorganism, having reduced or inactivated pyruvate : quinone oxidoreductase.
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公开(公告)号：EP3950927A1
公开(公告)日：2022-02-09
申请号：EP20781770.1
申请日：2020-04-01
申请人： Spiber Inc.
发明人： KOBAYASHI Masato , KURACHI Kenji , MORI Eiji , NODA Takanobu
摘要： The present invention relates to a method for producing a recombinant protein, the method including: a first step of culturing a recombinant cell expressing a recombinant protein under control of an inducible promoter in a medium containing galactose and at least two selected from the group consisting of mannitol, raffinose, and melibiose; and a second step of further culturing the recombinant cell under a condition that expression from the inducible promoter is induced after the first step.
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公开(公告)号：EP2623588B1
公开(公告)日：2022-01-19
申请号：EP11829379.4
申请日：2011-09-30
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公开(公告)号：EP3910096A1
公开(公告)日：2021-11-17
申请号：EP20738473.6
申请日：2020-01-09
申请人： Spiber Inc.
IPC分类号： D01F4/02 , C07K14/435 , C12P21/02 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , C12N15/63
摘要： The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A) n motif-REP] m or Formula 2: [(A) n motif-REP] m -(A) n motif, and having a serine residue content rate of less than 5.5%. [In Formula 1 and Formula 2, the (A) n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A) n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues. m represents an integer of 10 to 300. The plurality of (A) n motifs may be the same amino acid sequence or different amino acid sequences. A plurality of REPs may be the same amino acid sequence or different amino acid sequences.]
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公开(公告)号：EP3894442A1
公开(公告)日：2021-10-20
申请号：EP19896787.9
申请日：2019-12-11
发明人： NIE, Siwei , ZHENG, Yong , PAN, Jun , XU, Jianqing , LI, Jing
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公开(公告)号：EP3382024B1
公开(公告)日：2021-10-06
申请号：EP18172188.7
申请日：2010-06-04
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50.发明公开
公开(公告)号：EP3878944A1
公开(公告)日：2021-09-15
申请号：EP19882317.1
申请日：2019-11-04
申请人： Kikkoman Corporation
发明人： HARA, Seiichi
摘要： The objective of the present invention is to provide a transformed Aspergillus microorganism lacking at least two types of selection marker genes available for marker recycling method and a composition therefor. The objective can be achieved by a transformed Aspergillus microorganism lacking at least two types of selection marker genes available for marker recycling method on its chromosomes, or a composition for transforming an Aspergillus microorganism containing at least two types of nucleic acid fragments containing a loop-out region and a selection marker gene available for marker recycling method between homologous recombination regions, wherein the selection marker genes contain a tryptophan biosynthesis gene and a gene different from tryptophan biosynthesis gene.
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