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公开(公告)号：EP2973209A1
公开(公告)日：2016-01-20
申请号：EP14779748.4
申请日：2014-03-12
发明人： KOZICKI, Michael N.
IPC分类号： G06K7/10
CPC分类号： G06K7/1099 , G02B21/06 , G02B21/365 , G02B27/286 , G06F17/3028 , G06F17/30879 , G06K9/00147 , G06K9/00577 , G06K9/2027 , G06K9/46 , G06K9/4671 , G06K9/6202 , G06K19/06046 , G06K19/07749 , G06K19/086 , G06T7/0012 , G06T7/12 , G06T2207/10056 , G06T2207/30024 , G09C5/00 , H04L9/3278 , H04L2209/12
摘要： The disclosure features dendritic tags, and methods and systems for fabricating and using such tags. The methods can include obtaining at least one image of a dendritic tag attached to an article, analyzing the at least one image to identify a set of features associated with the dendritic tag, and comparing the set of features to stored information to identify the article.
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52.发明公开AUTOANTIBODY SIGNATURE FOR THE EARLY DETECTION OF OVARIAN CANCER 审中-公开AUTOANTIKÖRPERSIGNATURFÜRDIEFRÜHERKENNUNGVON EIERSTOCKKREBS
公开(公告)号：EP2951592A1
公开(公告)日：2015-12-09
申请号：EP14745938.2
申请日：2014-01-30
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , G01N33/57449 , G01N2333/471 , G01N2333/4748 , G01N2333/5756 , G01N2333/90666 , G01N2333/914 , G01N2800/7028
摘要： Methods for identifying antigens as potential biomarkers for the early detection of ovarian cancer, as well as kits for utilizing said antigens as biomarkers and in personalized medicine/therapeutics assessment. Protein microarrays displaying full-length candidate antigens were developed and sequentially screening to select candidate autoantibody biomarkers to limit the false discovery rate inherent to large-scale proteomic screening.
摘要翻译： 将抗原识别为用于早期检测卵巢癌的潜在生物标志物的方法，以及用于利用所述抗原作为生物标志物和个性化药物/治疗学评估的试剂盒。 开发显示全长候选抗原的蛋白质微阵列，并依次筛选选择候选自身抗体生物标志物，以限制大规模蛋白质组学筛选固有的假发现率。
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公开(公告)号：EP2900132A1
公开(公告)日：2015-08-05
申请号：EP13841482.6
申请日：2013-09-27
发明人： FORZANI, Erica , TAO, Nongjian , XIAN, Xiaojun , TSOW, Francis
IPC分类号： A61B5/08
CPC分类号： A61B5/082 , A61B5/087 , A61B5/097 , G01N33/497
摘要： A low back pressure mouthpiece for accurate detection of exhaled nitric oxide (NO) includes a conduit for receiving the exhaled breath from the subject. An oxidizing filter for sample conditioning, wherein the conduit and oxidizing filter operate to produce a back pressure of less than 4 cm H2O; and a device for measuring the level of one or more components of the received exhaled breath.
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公开(公告)号：EP2893061A1
公开(公告)日：2015-07-15
申请号：EP13834985.7
申请日：2013-09-05
IPC分类号： C40B30/04
CPC分类号： G01N33/6854 , G01N33/6845
摘要： Disclosed are methods and devices to provide efficient methods and systems for discovering therapeutic targets, novel antigens, and for deciphering an immunosignature. The invention discloses methods for the identification of unique peptides which form an immunosignature. The invention can be applied to target identifying screening in drug discovery.
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公开(公告)号：EP2771465A1
公开(公告)日：2014-09-03
申请号：EP12784832.3
申请日：2012-10-26
IPC分类号： C12N15/113 , C12N15/85
CPC分类号： C12N15/113 , C12N15/67 , C12N15/85 , C12N2830/30 , C12N2830/85 , C12N2840/105 , C12N2840/85
摘要： The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods.
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公开(公告)号：EP2771102A2
公开(公告)日：2014-09-03
申请号：EP12787975.7
申请日：2012-10-24
申请人： Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University , Engineering Arts LLC
发明人： WIKTOR, Peter , LABAER, Joshua , KAHN, Peter , TAKULAPALLI, Bharath , QIU, Ji , BRUNNER, Al , MAGEE, Mitch
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00317 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C12N15/1079 , C40B50/14 , C40B60/12 , G01N33/6845
摘要： Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography.
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57.发明公开GEOPOLYMER RESIN MATERIALS, GEOPOLYMER MATERIALS, AND MATERIALS PRODUCED THEREBY 审中-公开地聚合物树脂材料，地聚合物材料及其生产的材料
公开(公告)号：EP2758355A2
公开(公告)日：2014-07-30
申请号：EP12834535.2
申请日：2012-09-21
CPC分类号： C04B28/26 , C04B14/047 , C04B24/04 , C04B24/08 , C04B28/006 , C04B28/24 , C04B38/00 , Y02P40/165 , Y10T428/2982 , C04B12/04 , C04B14/106 , C04B22/062 , C04B38/0051 , C04B40/0071 , C04B40/0263
摘要： A product formed from a first material including a geopolymer resin material, a geopolymer resin, or a combination thereof by contacting the first material with a fluid and removing at least some of the fluid to yield a product. The first material may be formed by heating and/or aging an initial geopolymer resin material to yield the first material before contacting the first material with the fluid. In some cases, contacting the first material with the fluid breaks up or disintegrates the first material (e.g., in response to contact with the fluid and in the absence of external mechanical stress), thereby forming particles having an external dimension in a range between 1 nm and 2 cm.
摘要翻译： 由包含地质聚合物树脂材料，地质聚合物树脂或其组合的第一材料形成的产品，通过使第一材料与流体接触并除去至少一些流体以产生产品。 第一材料可以通过在使第一材料与流体接触之前加热和/或老化初始地质聚合物树脂材料以产生第一材料而形成。 在一些情况下，使第一材料与流体接触破碎或分解第一材料（例如响应于与流体接触并且在没有外部机械应力的情况下），由此形成具有在1范围内的外部尺寸的颗粒 nm和2厘米。
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公开(公告)号：EP1990346A3
公开(公告)日：2009-02-18
申请号：EP08014621.0
申请日：2003-12-09
IPC分类号： C07F9/6574 , A61K31/665 , A61P35/00
CPC分类号： C07F9/65744
摘要： The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various Narcissus species, said prodrugs having potential for use against human and animal cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including "narcistatin".
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公开(公告)号：EP0787009B1
公开(公告)日：2004-01-21
申请号：EP95940622.4
申请日：1995-11-06
IPC分类号： C07K5/00 , C07K5/02 , A61K38/04 , C07D207/08
CPC分类号： C07D207/08 , A61K38/00 , C07K5/0205 , C07K7/02
摘要： The sea hare Dolabella auricularia has yielded many structurally distinct peptides which possess antineoplastic activity. Presently the compound denominated 'dolastatin 10' represents the most important of such peptides because of its demonstrated potential as an anticancer drug. The present invention relates to the systematic creation of seven unique pentapeptides by selectively coupling a tripeptide-trifluoroacetate salt with a preselected dipeptide trifluoroacetate salt which provide active molecules capable of emulating the measured therapeutic effect of dolastatin 10.
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公开(公告)号：EP1045858A1
公开(公告)日：2000-10-25
申请号：EP99902120.7
申请日：1999-01-08
IPC分类号： C07K7/02
CPC分类号： C07K5/0205 , A61K38/00 , C07K7/02
摘要： Antifungals based on dolastatin 10 and four structural modifications thereof (herein 'peptides') and methods of treating a host afflicted with a fungi-induced infection are herein described. In broth macrodilution assays, these peptides were fungicidal for ATCC strains and clinical isolates of Cryptococcus neoformans. Speficitity for C. neoformans was also demonstrated in the solid-phase disk diffusion assay, and fungicidal activity confirmed in killing kinetics experiments. Broth macrodilution minimum inhibitory and minimum fungicidal concentrations for the most potent modification ranged from 0.0975-1.56 νg/ml, and 0.0975-6.24 νg/ml, respectively. The minimum inhibitory concentrations were nearly identical in the presence of human serum, but increased with lowered pH. Suitable dosage forms for use of the novel antifungals are also described.
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